2024
Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts
Urie R, Morris A, Farris D, Hughes E, Xiao C, Chen J, Lombard E, Feng J, Li J, Goldstein D, Shea L. Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts. Science Advances 2024, 10: eadk6178. PMID: 38748794, PMCID: PMC11095459, DOI: 10.1126/sciadv.adk6178.Peer-Reviewed Original ResearchConceptsGraft biopsyGraft injuryRag2<sup>-/-</sup> miceAdoptive transfer of T cellsTransfer of T cellsRejection of organ allograftsAcute cellular allograft rejectionCellular allograft rejectionEfficacy of immunosuppressionPredominant innate immune cellsInnate immune cellsRisk of rejectionWild-type animalsPersonalized immunosuppressionAdoptive transferAcute rejectionOrgan allograftsAllograft rejectionFrequent biopsiesT cellsImmune cellsTransplant rejectionImmunological nicheRespiratory infectionsInflammatory insult
2023
Tissue Engineering Scaffolds Remotely Surveil Presymptomatic Allograft Rejection
Urie R, Xiao C, Hughes E, Lombard E, Chen J, Morris A, Farris D, Goldstein D, Shea L. Tissue Engineering Scaffolds Remotely Surveil Presymptomatic Allograft Rejection. The Journal Of Immunology 2023, 210: 173.40-173.40. DOI: 10.4049/jimmunol.210.supp.173.40.Peer-Reviewed Original ResearchAcute cellular allograft rejectionEndomyocardial biopsyRisk of rejectionAllograft rejectionT cell-mediated rejectionRoutine endomyocardial biopsyCellular allograft rejectionHeterotopic heart transplantationMinimally-invasive samplingHealthy allograftsPersonalized immunosuppressionGraft biopsyPredictive biomarkersImmune suppressionHeart transplantationImmune cellsInvasive biopsyImmunological nicheHistological evidenceSkin transplantationBiopsyHistological evaluationGene profilesMolecular biomarkersPorous biomaterials