2023
Elevated glucose metabolism driving pro-inflammatory response in B cells contributes to the progression of type 1 diabetes
Li Z, Zhao M, Li J, Luo W, Huang J, Huang G, Xie Z, Xiao Y, Huang J, Li X, Zhao B, Zhou Z. Elevated glucose metabolism driving pro-inflammatory response in B cells contributes to the progression of type 1 diabetes. Clinical Immunology 2023, 255: 109729. PMID: 37562723, DOI: 10.1016/j.clim.2023.109729.Peer-Reviewed Original ResearchConceptsType 1 diabetesPro-inflammatory responseB cellsGlucose metabolismCytokine productionAberrant B cell responsesNon-obese diabetic (NOD) micePro-inflammatory cytokine productionHigh blood glucose levelsOnset of diabetesInflammatory cytokine productionAdaptive immune responsesB cell responsesCross-sectional cohortImmune system failureDiabetic mouse modelB cell functionBlood glucose levelsB cell populationsB cell metabolismPancreatic beta cellsB cell proliferationElevated glucose metabolismInsulitis developmentNOD mice
2022
Identification of monocyte-related transcriptomic signature of peripheral blood mononuclear cells in type 1 diabetes
Yin M, Zhang Y, Huang J, Li X, Yu H, Li X. Identification of monocyte-related transcriptomic signature of peripheral blood mononuclear cells in type 1 diabetes. Chinese Medical Journal 2022, 135: 2608-2610. PMID: 36583923, PMCID: PMC9943828, DOI: 10.1097/cm9.0000000000002142.Peer-Reviewed Original ResearchGene Expression Signatures Reveal Common Virus Infection Pathways in Target Tissues of Type 1 Diabetes, Hashimoto’s Thyroiditis, and Celiac Disease
Yin M, Zhang Y, Liu S, Huang J, Li X. Gene Expression Signatures Reveal Common Virus Infection Pathways in Target Tissues of Type 1 Diabetes, Hashimoto’s Thyroiditis, and Celiac Disease. Frontiers In Immunology 2022, 13: 891698. PMID: 35795668, PMCID: PMC9251511, DOI: 10.3389/fimmu.2022.891698.Peer-Reviewed Original ResearchConceptsHashimoto's thyroiditisCeliac diseaseAutoimmune diseasesTarget tissuesAutoimmune disordersHuman T-lymphotropic virus type 1Type 1 diabetes patientsMore autoimmune disordersPathogenesis of T1DType 1 diabetesCommon gene expression changesVirus type 1Gene expression signaturesSimplex infectionVirus infection pathwaysDiabetes patientsInfluenza APositive individualsVirus infectionT1DThyroiditisImmune systemType 1Gene signatureSimilar molecular signatures
2021
Innate immunity in latent autoimmune diabetes in adults
Huang J, Pearson JA, Wong FS, Wen L, Zhou Z. Innate immunity in latent autoimmune diabetes in adults. Diabetes/Metabolism Research And Reviews 2021, 38: e3480. PMID: 34156143, PMCID: PMC8813511, DOI: 10.1002/dmrr.3480.Peer-Reviewed Original ResearchConceptsType 1 diabetesDendritic cellsImmune cellsT cellsInnate immunityPathogenesis of LADALatent autoimmune diabetesAdaptive immune cellsPancreas of patientsType 2 diabetesImmune-associated genesIslet β-cellsAutoimmune diabetesClinical featuresImmunological reasonsAutoimmune diseasesRat modelB cellsDiabetesΒ-cellsImmunityPotential rolePathogenesisLADADisease
2020
Abnormal Neutrophil Transcriptional Signature May Predict Newly Diagnosed Latent Autoimmune Diabetes in Adults of South China
Xing Y, Lin Q, Tong Y, Zhou W, Huang J, Wang Y, Huang G, Li Y, Xiang Z, Zhou Z, Li T, Xiao Y. Abnormal Neutrophil Transcriptional Signature May Predict Newly Diagnosed Latent Autoimmune Diabetes in Adults of South China. Frontiers In Endocrinology 2020, 11: 581902. PMID: 33391182, PMCID: PMC7775642, DOI: 10.3389/fendo.2020.581902.Peer-Reviewed Original ResearchConceptsSex-matched healthy controlsLADA patientsHealthy controlsDevelopment of LADAPathological processesPeripheral blood neutrophilsCytokine-cytokine receptor interactionReal-time polymerase chain reactionLatent AutoimmuneAdhesion molecule signalingAutoimmune diabetesFunction deteriorationNeutrophil numbersPeripheral neutrophilsBlood neutrophilsPolymerase chain reactionPathological alterationsCell differentiationLeukocyte degranulationMyeloid cell differentiationGenomes (KEGG) pathway enrichmentPatientsPresent study resultsNeutrophilsTranscriptional levelAltered Systemic and Intestinal IgA Immune Responses in Individuals With Type 1 Diabetes
Huang J, Huang G, Li X, Hu F, Xie Z, Xiao Y, Luo S, Chao C, Guo K, Wong FS, Zhou Z, Wen L. Altered Systemic and Intestinal IgA Immune Responses in Individuals With Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa590. PMID: 32860693, PMCID: PMC7549925, DOI: 10.1210/clinem/dgaa590.Peer-Reviewed Original ResearchConceptsIgA-bound bacteriaType 1 diabetesHealthy control individualsIgA immune responseControl individualsIgA immunityAutoantibody titersIgA concentrationsImmune responseType 1 diabetes patientsΒ-cell autoimmunityLonger disease durationSerum IgA concentrationNovel therapeutic targetEnzyme-linked immunosorbentDisease durationIgA levelsDiabetes patientsDiabetes displayGut homeostasisBlood samplesOral cavityTherapeutic targetDiabetesHost immunityGut microbial metabolites alter IgA immunity in type 1 diabetes
Huang J, Pearson JA, Peng J, Hu Y, Sha S, Xing Y, Huang G, Li X, Hu F, Xie Z, Xiao Y, Luo S, Chao C, Wong F, Zhou Z, Wen L. Gut microbial metabolites alter IgA immunity in type 1 diabetes. JCI Insight 2020, 5 PMID: 32298241, PMCID: PMC7259536, DOI: 10.1172/jci.insight.135718.Peer-Reviewed Original ResearchConceptsType 1 diabetesGut microbiotaNOD miceImmune responseGerm-free NOD miceIgA immune responseIgA-mediated immunityHealthy control subjectsPotential therapeutic agentShort-chain fatty acid productionIgA immunityT1D preventionIgA responsesControl subjectsDecreased severityT1DTherapeutic agentsFunctional effectsMicrobiotaDiabetesPatientsUnderlying mechanismMiceImmunitySCFAAbnormal Peripheral Neutrophil Transcriptome in Newly Diagnosed Type 2 Diabetes Patients
Lin Q, Zhou W, Wang Y, Huang J, Hui X, Zhou Z, Xiao Y. Abnormal Peripheral Neutrophil Transcriptome in Newly Diagnosed Type 2 Diabetes Patients. Journal Of Diabetes Research 2020, 2020: 9519072. PMID: 32377527, PMCID: PMC7195634, DOI: 10.1155/2020/9519072.Peer-Reviewed Original ResearchConceptsType 2 diabetes patientsGene OntologyType 2 diabetesComprehensive transcriptome analysisKEGG pathway enrichment analysisCytokine receptor interaction pathwayMyeloid leukocyte activationPathway enrichment analysisReceptor interaction pathwayQPCR of genesGene expression analysisDiabetes patientsHealthy controlsUpregulated DEGsTranscriptome analysisTranscriptome levelGO analysisKEGG pathwaysRNA sequencingCell adhesion moleculeExpression analysisEnrichment analysisInteraction pathwayMolecular mechanismsDEGs
2018
Distinct neutrophil counts and functions in newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes
Huang J, Xiao Y, Zheng P, Zhou W, Wang Y, Huang G, Xu A, Zhou Z. Distinct neutrophil counts and functions in newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes. Diabetes/Metabolism Research And Reviews 2018, 35: e3064. PMID: 30123986, DOI: 10.1002/dmrr.3064.Peer-Reviewed Original ResearchConceptsNeutrophil countType 1 diabetesT1D patientsNeutrophil numbersPhagocytosis rateTitres of autoantibodiesΒ-cell antigensΒ-cell autoimmunityChemokine receptor expressionType 2 diabetesMigration of neutrophilsLADA patientsPositive autoantibodiesAutoimmune diabetesChemokine levelsCD62L expressionT2D patientsClinical parametersNeutrophil migrationHealthy controlsReceptor expressionAnimal modelsDiabetesPatientsDifferent subtypes
2016
Neutrophils in type 1 diabetes
Huang J, Xiao Y, Xu A, Zhou Z. Neutrophils in type 1 diabetes. Journal Of Diabetes Investigation 2016, 7: 652-663. PMID: 27181374, PMCID: PMC5009125, DOI: 10.1111/jdi.12469.Peer-Reviewed Original ResearchConceptsType 1 diabetesImmune cellsDiabetogenic T cell responseAutoimmune type 1 diabetesType 1 diabetes pathogenesisType 1 diabetes developmentΒ-cellsInsulin-producing pancreatic β-cellsProgression of insulitisT cell responsesFirst immune cellsNon-immune cellsImmune cell typesPancreatic β-cellsDendritic cellsDiabetes developmentAutoimmune diseasesDegranulation productsDiabetes pathogenesisExtracellular trapsT cellsDiabetesCell responsesNeutrophilsIslet cells