2009
Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects
Nath AK, Krauthammer M, Li P, Davidov E, Butler LC, Copel J, Katajamaa M, Oresic M, Buhimschi I, Buhimschi C, Snyder M, Madri JA. Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects. PLOS ONE 2009, 4: e4221. PMID: 19156209, PMCID: PMC2626248, DOI: 10.1371/journal.pone.0004221.Peer-Reviewed Original ResearchConceptsCardiovascular developmentMass spectrometry-based proteomicsSpectrometry-based proteomicsNormal cardiovascular developmentAdhesion/migrationHuman CHDsProteomic datasetsHeart developmentProtein clustersMurine embryosProtein pathwayMolecular pathwaysFunctional roleProteinEmbryonic survivalYolk sacProtein levelsIdentifies biomarkersCardiovascular defectsWestern blottingPathwayNovel avenuesEmbryosComplete understandingProtein biomarkers
1998
Immunohistochemical localization of inducible nitric oxide synthase on human fetal amnion in intra-amniotic infection
Hsu C, Meaddough E, Lu L, Chelouche A, Liang R, Copel J, Parkash V. Immunohistochemical localization of inducible nitric oxide synthase on human fetal amnion in intra-amniotic infection. American Journal Of Obstetrics And Gynecology 1998, 179: 1271-1274. PMID: 9822514, DOI: 10.1016/s0002-9378(98)70145-0.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseIntra-amniotic infectionNitric oxide synthaseFetal amniotic membranesOxide synthaseFetal amnionNitric oxideAmniotic membranePositive amniotic fluid culturePlacental pathologic featuresAmniotic fluid levelsNitric oxide metabolitesAnti-inducible nitric oxide synthaseAmniotic fluid cultureNormal rabbit serumOvarian carcinoma cellsHuman inducible nitric oxide synthaseInfectious productsPathologic featuresOxide metabolitesFluid culturePositive immunostainingRabbit polyclonal antibodyImmunohistochemical localizationFluid levels
1993
Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. comparison of enzyme‐linked immunosorbent assay and immunoblot for measurement of anti–ss‐a/ro and anti–ss‐b/la antibodies
Buyon J, Winchester R, Slade S, Arnett F, Copel J, Friedman D, Lockshin M. Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. comparison of enzyme‐linked immunosorbent assay and immunoblot for measurement of anti–ss‐a/ro and anti–ss‐b/la antibodies. Arthritis & Rheumatism 1993, 36: 1263-1273. PMID: 8216420, DOI: 10.1002/art.1780360911.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayNeonatal lupus syndromeNeonatal lupusCongenital heart blockHeart blockSDS-immunoblotRo antibodiesHealthy infantsMothers of childrenLupus syndromeLa antibodiesFetal deathAutoimmune diseasesRo antigenRo responseDetectable cardiac involvementFetal death groupSystemic lupus erythematosusSpecific antibody profileMothers of infantsRelated autoimmune diseasesIdentification of mothersEnzyme-linked immunosorbentFine specificity patternsGroups of mothers
1992
Fetal Cardiovascular Physiology and Therapy
Kleinman C, Copel J. Fetal Cardiovascular Physiology and Therapy. Fetal Diagnosis And Therapy 1992, 7: 147-157. PMID: 1503650, DOI: 10.1159/000263663.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFetal cardiovascular physiologyFetal lamb modelHuman fetal heartSurgical interventionFetal heartLamb modelCardiovascular physiologyFetal cardiovascular malformationsFetal ductus arteriosusFetal cardiovascular systemVentricular filling characteristicsFetal cardiac developmentSystolic reserveVentricular afterloadDuctus arteriosusThird trimesterForamen ovaleNeonatal periodVentricular hypoplasiaFetal lambsShunt flowPrenatal interventionTimely therapyCardiovascular malformationsHuman fetuses
1990
Does the umbilical artery systolic/diastolic ratio reflect flow or acidosis? An umbilical artery Doppler study of fetal sheep
Copel J, Schlafer D, Wentworth R, Belanger K, Kreitzer L, Hobbins J, Nathanielsz P. Does the umbilical artery systolic/diastolic ratio reflect flow or acidosis? An umbilical artery Doppler study of fetal sheep. American Journal Of Obstetrics And Gynecology 1990, 163: 751-756. PMID: 2206067, DOI: 10.1016/0002-9378(90)91062-h.Peer-Reviewed Original ResearchConceptsSystolic/diastolic ratioUmbilical artery systolic/diastolic ratioDiastolic ratioFetal sheepNormal systolic/diastolic ratioUmbilical artery Doppler studiesArterial blood gas levelsBlood gas levelsAcid-base statusArtery embolizationFetal oxygenationPlacental perfusionMaternal anesthesiaPlacental embolizationAcute modelDoppler studiesThird injectionUmbilical flowFourth injectionSubsequent embolizationDays gestationFirst injectionSecond injectionEmbolizationGreater magnitude change