2022
NAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone
Sunderji S, Peyvandi S, Jaeggi E, Szwast A, Ryan G, Tessier F, Siddiqui S, Cuneo B, Sheth S, Treadwell M, Frommelt M, Turan S, Copel J, Emery S, Rand L, Moon-Grady AJ, Network F. NAFTNet retrospective report on the treatment of anti-Ro/SSA mediated fetal heart block with dexamethasone. The Journal Of Maternal-Fetal & Neonatal Medicine 2022, 35: 9263-9270. PMID: 35014577, DOI: 10.1080/14767058.2022.2025536.Peer-Reviewed Original ResearchConceptsPositive pregnanciesPrimary outcomePregnancy complicationsPregnancy outcomesPremature deliverySecondary outcomesNorth American Fetal Therapy Network (NAFTNet) centersRo/SSA-positive pregnanciesRetrospective multi-center cohort studyAnti-Ro/SSAMulti-center cohort studyFetal heart blockOverall pregnancy complicationsBetter pregnancy outcomesPoor pregnancy outcomesUse of dexamethasoneTerms of efficacyHigh rateFetal dyadsMaternal comorbiditiesAntibody positivityExpectant managementMaternal diseaseNeonatal morbidityPreterm delivery
2020
Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers
Izmirly P, Kim M, Friedman DM, Costedoat-Chalumeau N, Clancy R, Copel JA, Phoon CKL, Cuneo BF, Cohen RE, Robins K, Masson M, Wainwright BJ, Zahr N, Saxena A, Buyon JP. Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers. Journal Of The American College Of Cardiology 2020, 76: 292-302. PMID: 32674792, PMCID: PMC7394202, DOI: 10.1016/j.jacc.2020.05.045.Peer-Reviewed Original ResearchConceptsCongenital heart blockPrimary outcomeSecondary outcomesEndocardial fibroelastosisHeart blockRecurrence of CHBSSA/Ro-positive mothersAnti-SSA/RoMacrophage Toll-like receptorToll-like receptor antagonistsCutaneous neonatal lupusRo-positive mothersGestational weeks 10Toll-like receptorsFetal cardiac diseaseNeonatal lupusPositive mothersSecondary preventionSkin rashPrevious pregnancyTreat analysisClinical evidenceRecurrence rateReceptor antagonistOptimal approach
2013
ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart
International Society of Ultrasound in Obstetrics and Gynecology, Carvalho J, Allan L, Chaoui R, Copel J, DeVore G, Hecher K, Lee W, Munoz H, Paladini D, Tutschek B, Yagel S. ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart. Ultrasound In Obstetrics And Gynecology 2013, 41: 348-359. PMID: 23460196, DOI: 10.1002/uog.12403.Commentaries, Editorials and Letters
2009
Prospective Evaluation of Fetuses With Autoimmune-Associated Congenital Heart Block Followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study
Friedman DM, Kim MY, Copel JA, Llanos C, Davis C, Buyon JP. Prospective Evaluation of Fetuses With Autoimmune-Associated Congenital Heart Block Followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study. The American Journal Of Cardiology 2009, 103: 1102-1106. PMID: 19361597, PMCID: PMC2730772, DOI: 10.1016/j.amjcard.2008.12.027.Peer-Reviewed Original ResearchConceptsThird-degree blockSecond-degree blockCongenital heart blockFirst-degree blockDEX groupHeart blockAutoimmune-Associated Congenital Heart BlockEfficacy of dexamethasoneSteroid side effectsNormal sinus rhythmMedian ventricular ratesCardiac dysfunctionGestational ageVentricular rateNonrandomized studyProspective evaluationSinus rhythmGrowth restrictionPR intervalPacemaker useRare caseTherapeutic benefitSide effectsBirth ageDexamethasone
2008
Prenatal Imaging
Reddy UM, Filly RA, Copel JA. Prenatal Imaging. Obstetrics And Gynecology 2008, 112: 145-157. PMID: 18591320, PMCID: PMC2788813, DOI: 10.1097/01.aog.0000318871.95090.d9.Peer-Reviewed Original ResearchConceptsFetal magnetic resonance imagingMagnetic resonance imagingNervous system anomaliesFetal central nervous system anomaliesEunice Kennedy Shriver National InstituteCentral nervous system anomaliesNon-central nervous system anomaliesSystem anomaliesFirst-trimester ultrasonographyPrediction of prognosisModality of choiceThree-dimensional ultrasonographyAnatomic surveySpecialized centersFetal sedationFetal observationsChild healthPregnancy evaluationPrenatal imagingUltrasonographyResonance imagingAvailable evidenceRemote reviewNational InstituteClinical applicationPrenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography. Journal Of Ultrasound In Medicine 2008, 27: 715-720. PMID: 18424646, DOI: 10.7863/jum.2008.27.5.715.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDown SyndromeEchocardiographyFemaleFetal DevelopmentFetal DiseasesFetal HeartFollow-Up StudiesGestational AgeHeart Septal Defects, VentricularHumansInfant, NewbornNuchal Translucency MeasurementPregnancyPregnancy OutcomeProspective StudiesRisk AssessmentTripletsTwinsUltrasonography, Doppler, ColorUltrasonography, PrenatalConceptsVentricular septal defectColor Doppler examinationMuscular VSDDoppler examinationSeptal defectStudy groupIsolated muscular ventricular septal defectTrisomy 21Isolated ventricular septal defectMuscular ventricular septal defectsHigh-resolution ultrasound equipmentCommon congenital heart defectSmall muscular VSDMean gestational ageFetal echocardiographic examinationColor Doppler sonographyCongenital heart defectsPrenatal resolutionTriplet gestationsEchocardiographic examinationGestational ageCounseling patientsPerinatal courseTwin gestationsFirst trimester
2004
Indications for Fetal Echocardiography
Small M, Copel J. Indications for Fetal Echocardiography. Pediatric Cardiology 2004, 25: 210-222. PMID: 15360114, DOI: 10.1007/s00246-003-0587-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2001
Transvaginal sonographic evaluation of fetal anatomy at 14 to 16 weeks. Why it is not feasible in the United States.
Copel J. Transvaginal sonographic evaluation of fetal anatomy at 14 to 16 weeks. Why it is not feasible in the United States. Journal Of Ultrasound In Medicine 2001, 20: 710-711. PMID: 11444728, DOI: 10.7863/jum.2001.20.7.710.Commentaries, Editorials and LettersIsolated major congenital heart disease
Allan L, Benacerraf B, Copel J, Carvalho J, Chaoui R, Eik-Nes S, Tegnander E, Gembruch U, Huhta J, Pilu G, Wladimiroff J, Yagel S. Isolated major congenital heart disease. Ultrasound In Obstetrics And Gynecology 2001, 17: 370-379. PMID: 11380959, DOI: 10.1046/j.1469-0705.2001.00439.x.Peer-Reviewed Original ResearchPrenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient
Verheijen P, Lisowski L, Stoutenbeek P, Hitchcock J, Brenner J, Copel J, Kleinman C, Meijboom E, Bennink G. Prenatal diagnosis of congenital heart disease affects preoperative acidosis in the newborn patient. Journal Of Thoracic And Cardiovascular Surgery 2001, 121: 798-803. PMID: 11279423, DOI: 10.1067/mtc.2001.112825.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseHeart diseaseLower base excessHeart obstructionMetabolic acidosisBase excessDuctus-dependent congenital heart diseasePrenatal diagnosisPostnatal diagnosisImproved long-term outcomesGroup of patientsArterial blood gasesLong-term outcomesCause of deathHigher lactate levelsDays of lifePrevention of acidosisSignificant differencesBiventricular repairPreoperative conditionCerebral damageRetrospective studySurgical outcomesPreoperative acidosisBlood gases
2000
Human caudal appendage diagnosed prenatally with ultrasound.
Harirah H, Hsu C, Bahado-Singh R, Copel J. Human caudal appendage diagnosed prenatally with ultrasound. Obstetrics And Gynecology 2000, 95: 1038. PMID: 10808025, DOI: 10.1016/s0029-7844(00)00820-6.Peer-Reviewed Case Reports and Technical NotesSplenic artery Doppler peak systolic velocity predicts severe fetal anemia in rhesus disease
Bahado-Singh R, Oz U, Deren O, Kovanchi E, Hsu C, Copel J, Mari G. Splenic artery Doppler peak systolic velocity predicts severe fetal anemia in rhesus disease. American Journal Of Obstetrics And Gynecology 2000, 182: 1222-1226. PMID: 10819862, DOI: 10.1016/s0002-9378(00)70189-x.Peer-Reviewed Original ResearchConceptsDoppler peak systolic velocityPeak systolic velocitySevere anemiaSystolic velocityPrior transfusionsGestational ageHemoglobin deficitStudy groupSplenic artery peak systolic velocityMean peak systolic velocityPeak systolic velocity valuesMean gestational ageOverall study groupSevere fetal anemiaCord blood specimensSystolic velocity valuesNonhydropic fetusesMean hemoglobinRhesus diseaseFetal anemiaFetal hydropsStudy populationBlood specimensNormal fetusesFirst such report
1999
Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody‐associated congenital heart block: Retrospective review of the research registry for neonatal lupus
Saleeb S, Copel J, Friedman D, Buyon J. Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody‐associated congenital heart block: Retrospective review of the research registry for neonatal lupus. Arthritis & Rheumatism 1999, 42: 2335-2345. PMID: 10555029, DOI: 10.1002/1529-0131(199911)42:11<2335::aid-anr12>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsCongenital heart blockSecond-degree blockThird-degree blockGroup B fetusesGroup BGroup AHeart blockAge 4 yearsNeonatal lupusPericardial effusionPleural effusionResearch RegistryFluorinated steroidsAutoantibody-associated congenital heart blockAnti-SSB/La antibodiesAnti-SSA/RoFluorinated glucocorticoidsNatural historyInitial echocardiographic evaluationDuration of pregnancyIntrauterine growth restrictionFirst-degree blockNumber of deathsComparison of treatmentsSteroid therapy
1997
The effect of intravascular blood transfusion on the flow velocity waveform of the portal venous system of the anemic fetus
d'Ancona R, Rahman F, Ozcan T, Copel J, Mari G. The effect of intravascular blood transfusion on the flow velocity waveform of the portal venous system of the anemic fetus. Ultrasound In Obstetrics And Gynecology 1997, 10: 333-337. PMID: 9444047, DOI: 10.1046/j.1469-0705.1997.10050333.x.Peer-Reviewed Original ResearchConceptsFlow velocity waveformsPortal venous systemAnemic fetusesVelocity waveformsPortal hypertensionIntravascular transfusionPortal veinVenous systemNormal fetusesIntravascular blood transfusionNon-pulsatile flowBlood transfusionRhesus alloimmunizationGestational agePulsatile patternTransfusionFetusesPresence of pulsatilityHypertensionIncreased numberCardiac cyclePulsatileVeinAlloimmunizationUteroMANAGEMENT OF FETAL CARDIAC ARRHYTHMIAS
Copel J, Friedman A, Kleinman C. MANAGEMENT OF FETAL CARDIAC ARRHYTHMIAS. Obstetrics And Gynecology Clinics Of North America 1997, 24: 201-211. PMID: 9086526, DOI: 10.1016/s0889-8545(05)70297-7.Chapters
1995
Management of the Rh-Sensitizeo Mother
Gollin Y, Copel J. Management of the Rh-Sensitizeo Mother. Clinics In Perinatology 1995, 22: 545-559. PMID: 8521681, DOI: 10.1016/s0095-5108(18)30268-9.ChaptersMeSH KeywordsAnemiaFemaleFetal DiseasesHumansPregnancyPregnancy Complications, HematologicRh IsoimmunizationRisk FactorsConceptsRh immune globulinManagement of complicationsRh D typingEarly referralIntrauterine transfusionImmune globulinRh isoimmunizationTertiary centerAnemic fetusesNeonatal careFetal bloodInvasive techniquesLung maturityPrompt identificationD typingClinical situationsOptimal managementFetusesMothersTransfusionComplicationsIsoimmunizationNeonatesNeonatologistsPerinatologistsFifth digit measurement in normal pregnancies: a potential sonographic sign of Down's syndrome
Goldstein I, Gomez K, Copel J. Fifth digit measurement in normal pregnancies: a potential sonographic sign of Down's syndrome. Ultrasound In Obstetrics And Gynecology 1995, 5: 34-37. PMID: 7850587, DOI: 10.1046/j.1469-0705.1995.05010034.x.Peer-Reviewed Original ResearchConceptsGestational ageFifth fingerBiparietal diameterDown syndromeFemoral lengthHumeral lengthRoutine biometric measurementsNormal pregnancyWeeks' gestationStudy groupSonographic signsNormal fetusesSyndromePrenatal detectionFurther studiesGestationAgeNormative dataFetusesBiometric measurementsFingerLinear growthDigit measurementsPregnancy
1994
Management outcome and follow-up of fetal tachycardia
van Engelen A, Weijtens O, Brenner J, Kleinman C, Copel J, Stoutenbeek P, Meijboom E. Management outcome and follow-up of fetal tachycardia. Journal Of The American College Of Cardiology 1994, 24: 1371-1375. PMID: 7930263, DOI: 10.1016/0735-1097(94)90122-8.Peer-Reviewed Original ResearchConceptsFetal tachycardiaMajority of patientsPharmacologic therapyFetal hydropsAtrial flutterSupraventricular tachycardiaVentricular tachycardiaPresence of hydropsSeries of patientsLife-threatening conditionSerious adverse effectsMonths of ageMaternal therapyProlonged therapyPostpartum managementRhythm controlAntiarrhythmic agentsMedian numberDrug treatmentTachycardiaM-modePatientsOptimal managementTherapyEmergency deliveryRoutine ultrasound screening
Gomez K, Copel J. Routine ultrasound screening. Current Opinion In Obstetrics & Gynecology 1994, 6: 426-429. PMID: 7827272, DOI: 10.1097/00001703-199410000-00006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe real-time and color Doppler appearance of adrenal neuroblastoma in a third-trimester fetus.
Goldstein I, Gomez K, Copel J. The real-time and color Doppler appearance of adrenal neuroblastoma in a third-trimester fetus. Obstetrics And Gynecology 1994, 83: 854-6. PMID: 8159375.Peer-Reviewed Case Reports and Technical NotesConceptsDoppler flow studiesCommon malignant tumorColor Doppler appearanceThird-trimester fetusesFlow mappingColor flow mappingFetal neuroblastomaAdrenal neuroblastomaWeeks' gestationUltrasound evaluationRenal poleDoppler appearanceMalignant tumorsColor DopplerUse of ultrasoundPrenatal recognitionNeuroblastomaGestationTumorsFlow studiesUltrasonographyFetusesDiagnosisWomen