2021
Special Report of the Society for Maternal-Fetal Medicine Placenta Accreta Spectrum Ultrasound Marker Task Force: Consensus on definition of markers and approach to the ultrasound examination in pregnancies at risk for placenta accreta spectrum
Shainker SA, Coleman B, Timor I, Bhide A, Bromley B, Cahill AG, Gandhi M, Hecht JL, Johnson KM, Levine D, Mastrobattista J, Philips J, Platt L, Shamshirsaz AA, Shipp TD, Silver RM, Simpson LL, Copel JA, Abuhamad A, Medicine S. Special Report of the Society for Maternal-Fetal Medicine Placenta Accreta Spectrum Ultrasound Marker Task Force: Consensus on definition of markers and approach to the ultrasound examination in pregnancies at risk for placenta accreta spectrum. American Journal Of Obstetrics And Gynecology 2021, 224: b2-b14. PMID: 33386103, DOI: 10.1016/j.ajog.2020.09.001.Peer-Reviewed Original ResearchConceptsPlacenta accreta spectrumUltrasound examinationAmerican CollegePrenatal ultrasound evaluationMaternal-fetal medicineAbnormal placental attachmentTask ForcePlacenta percretaMaternal morbidityPlacenta accretaPlacenta incretaAdherent placentaCesarean deliveryUltrasound evaluationDiagnostic medical sonographySonographic markersUltrasound markersPlacental attachmentExpert consensusInvasive placentationDefinition of markersPrenatal detectionAmerican RegistryUltrasoundPregnancy
2019
Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions
Tuzovic L, Copel JA, Stitelman DH, Levit O, Bahtiyar MO. Utility of Fetal Cardiac Axis and Cardiac Position Assessment in Predicting Neonatal Respiratory Morbidity in Fetal Congenital Lung Lesions. Journal Of Ultrasound In Medicine 2019, 38: 2361-2372. PMID: 30653685, DOI: 10.1002/jum.14931.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesFemaleFetal HeartHumansLungLung DiseasesPregnancyRetrospective StudiesSensitivity and SpecificityUltrasonography, PrenatalYoung AdultConceptsAbnormal cardiac axisNegative predictive valueFetal cardiac axisNeonatal respiratory morbidityRespiratory morbidityCongenital lung lesionsCardiac positionPositive predictive valuePredictive valueCardiac axisLung lesionsHigh negative predictive valueSevere respiratory morbidityRetrospective cohort studyRight-sided lesionsNormal cardiac axisCohort studyWeeks' gestationMorbidityCP assessmentWeeksDiagnostic performanceLesionsPatientsGestation
2012
Comparative Analysis of 2-D Versus 3-D Ultrasound Estimation of the Fetal Adrenal Gland Volume and Prediction of Preterm Birth
Turan O, Turan S, Buhimschi I, Funai E, Campbell K, Bahtiyar O, Harman C, Copel J, Baschat A, Buhimschi C. Comparative Analysis of 2-D Versus 3-D Ultrasound Estimation of the Fetal Adrenal Gland Volume and Prediction of Preterm Birth. American Journal Of Perinatology 2012, 29: 673-680. PMID: 22644825, PMCID: PMC3838705, DOI: 10.1055/s-0032-1314887.Peer-Reviewed Original Research
2001
Ratio of nuchal thickness to humerus length for Down syndrome detection
Bahado-Singh R, Oz U, Hsu C, Deren O, Copel J, Mahoney M. Ratio of nuchal thickness to humerus length for Down syndrome detection. American Journal Of Obstetrics And Gynecology 2001, 184: 1284-1288. PMID: 11349203, DOI: 10.1067/mob.2001.113878.Peer-Reviewed Original ResearchConceptsDown syndrome riskHigh-risk groupMaternal ageSyndrome riskNuchal thicknessDown syndromeDown syndrome detectionStudy populationIndividual Down's syndrome riskMean gestational ageOverall study populationAge-related riskHumerus lengthSyndrome detectionDown syndrome casesDown's syndrome likelihood ratiosGestational ageProspective dataHealthy groupGross anomaliesNormal fetusesSyndrome casesBiparietal diameterAmniocentesis casesFetal populationCan Risk Factor Assessment Replace Universal Screening for Gonorrhea and Chlamydia in the Third Trimester?
Magriples U, Copel J. Can Risk Factor Assessment Replace Universal Screening for Gonorrhea and Chlamydia in the Third Trimester? American Journal Of Perinatology 2001, 18: 465-468. PMID: 11733863, DOI: 10.1055/s-2001-18790.Peer-Reviewed Original ResearchConceptsThird trimesterPrenatal careInitial negative testNegative initial screenRisk factor screeningThird-trimester testingUrban clinic populationFirst prenatal visitHistory of STDNegative predictive valueAbsence of RFRF screeningPrenatal visitChlamydia screeningGestational agePositive RFStudy criteriaClinic populationClinic settingUniversal screeningLower riskProspective analysisNegative testPredictive valueDrug use
2000
Splenic artery Doppler peak systolic velocity predicts severe fetal anemia in rhesus disease
Bahado-Singh R, Oz U, Deren O, Kovanchi E, Hsu C, Copel J, Mari G. Splenic artery Doppler peak systolic velocity predicts severe fetal anemia in rhesus disease. American Journal Of Obstetrics And Gynecology 2000, 182: 1222-1226. PMID: 10819862, DOI: 10.1016/s0002-9378(00)70189-x.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaFalse Positive ReactionsFemaleFetal DiseasesGestational AgeHumansLaser-Doppler FlowmetryPregnancyRh IsoimmunizationROC CurveSensitivity and SpecificitySplenic ArterySystoleConceptsDoppler peak systolic velocityPeak systolic velocitySevere anemiaSystolic velocityPrior transfusionsGestational ageHemoglobin deficitStudy groupSplenic artery peak systolic velocityMean peak systolic velocityPeak systolic velocity valuesMean gestational ageOverall study groupSevere fetal anemiaCord blood specimensSystolic velocity valuesNonhydropic fetusesMean hemoglobinRhesus diseaseFetal anemiaFetal hydropsStudy populationBlood specimensNormal fetusesFirst such reportCombined ultrasound biometry, serum markers and age for Down syndrome risk estimation
Bahado‐Singh R, Oz A, Gomez K, Hunter D, Copel J, Baumgarten A, Mahoney M. Combined ultrasound biometry, serum markers and age for Down syndrome risk estimation. Ultrasound In Obstetrics And Gynecology 2000, 15: 199-204. PMID: 10846774, DOI: 10.1046/j.1469-0705.2000.00071.x.Peer-Reviewed Original ResearchConceptsMaternal ageAlpha-fetoproteinTriple screenSerum markersUltrasound biometryDown syndromeNuchal thickness measurementMedian maternal ageSerum alpha-fetoproteinNormal singleton pregnanciesHumerus lengthGestational age rangeDown's syndrome screening efficiencySingleton pregnanciesReferral populationFalse positive rateSecond trimesterIndividual Down syndrome oddsFetal biometryUnconjugated estriolStudy groupNuchal thicknessDown syndrome risk estimationHCGAge rangeNoninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization
Mari G, Deter R, Carpenter R, Rahman F, Zimmerman R, Moise K, Dorman K, Ludomirsky A, Gonzalez R, Gomez R, Oz U, Detti L, Copel J, Bahado-Singh R, Berry S, Martinez-Poyer J, Blackwell S. Noninvasive Diagnosis by Doppler Ultrasonography of Fetal Anemia Due to Maternal Red-Cell Alloimmunization. New England Journal Of Medicine 2000, 342: 9-14. PMID: 10620643, DOI: 10.1056/nejm200001063420102.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityBlood Group IncompatibilityCordocentesisErythroblastosis, FetalErythrocytesFemaleFetal BloodGestational AgeHemoglobinsHumansInfant, NewbornIsoantibodiesMiddle Cerebral ArteryPregnancyPregnancy Complications, HematologicProspective StudiesReference ValuesRh IsoimmunizationROC CurveSensitivity and SpecificityUltrasonography, Doppler, PulsedUltrasonography, PrenatalConceptsMaternal red cell alloimmunizationRed cell alloimmunizationMiddle cerebral arterySystolic blood flowCerebral arteryBlood flowSevere anemiaFetal anemiaDoppler ultrasonographyNormal fetusesHemoglobin concentrationFetal middle cerebral arteryPeak velocityFetal hemoglobin concentrationAbsence of hydropsPeak systolic velocityGestational ageModerate anemiaSystolic velocityHemoglobin valuesMild anemiaInvasive techniquesAlloimmunizationAnemiaArtery
1999
A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age
Bahado-Singh R, Oz U, Kovanci E, Cermik D, Copel J, Mahoney M, Cole L. A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age. American Journal Of Obstetrics And Gynecology 1999, 180: 169-173. PMID: 9914599, DOI: 10.1016/s0002-9378(99)70170-5.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageNuchal thicknessMaternal ageGenetic amniocentesisDown syndrome detection rateUrinary beta-core fragmentUrinary analytesMaternal age-related riskRisk thresholdSyndrome detection rateTotal study populationHigh-risk groupAge-related riskBeta-core fragmentRate of amniocentesisHuman chorionic gonadotropinDown syndrome riskDown's syndrome likelihood ratiosDown's syndrome screening efficiencyLikelihood ratioCommon indicationFalse positive rateNormal medianPregnant womenSyndrome risk
1998
New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age
Bahado-Singh R, Oz A, Kovanci E, Deren O, Copel J, Baumgarten A, Mahoney J. New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age. American Journal Of Obstetrics And Gynecology 1998, 179: 1627-1631. PMID: 9855608, DOI: 10.1016/s0002-9378(98)70036-5.Peer-Reviewed Original ResearchConceptsHumerus length measurementsSerum markersDown syndromeMaternal ageTriple screenHumerus lengthMultiple stepwise logistic regression analysisTriple-marker serum screeningSerum analytesStepwise logistic regression analysisScreening algorithmHigh-risk populationFetal Down syndromeMultiple serum markersDown syndrome screeningHuman chorionic gonadotropinLogistic regression analysisNew screening algorithmDown's syndrome screening efficiencyPrenatal Down syndrome screeningDown syndrome detectionFalse positive rateSerum screenSingleton fetusesUnconjugated estriolAccurate detection of anomalies by routine ultrasonography in an indigent clinic population
Magriples U, Copel J. Accurate detection of anomalies by routine ultrasonography in an indigent clinic population. American Journal Of Obstetrics And Gynecology 1998, 179: 978-981. PMID: 9790383, DOI: 10.1016/s0002-9378(98)70201-7.Peer-Reviewed Original ResearchConceptsVentricular septal defectScreening ultrasonographyRoutine ultrasonographyClinic populationSeptal defectRoutine screening ultrasonographyImmediate neonatal periodTermination of pregnancyPositive predictive valueMisshapen earsNeonatal chartsExtralobar sequestrationGroup of sonographersWeeks' gestationGreat arteriesNeonatal periodRetrospective studyResident clinicUltrasonographic resultsImperforate anusIndigent populationObstetric ultrasonographyFetal monitoringUltrasonographyPredictive valueArterial and venous Doppler velocimetry in the severely growth‐restricted fetus and associations with adverse perinatal outcome
Ozcan T, Sbracia M, d'Ancona R, Copel J, Mari G. Arterial and venous Doppler velocimetry in the severely growth‐restricted fetus and associations with adverse perinatal outcome. Ultrasound In Obstetrics And Gynecology 1998, 12: 39-44. PMID: 9697283, DOI: 10.1046/j.1469-0705.1998.12010039.x.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityCerebral ArteriesFemaleFetal Growth RetardationFetusHumansInfant, NewbornPregnancyPregnancy OutcomePrognosisPulsatile FlowReference ValuesSensitivity and SpecificitySignal Processing, Computer-AssistedSurvival RateUltrasonography, Doppler, ColorUltrasonography, PrenatalUmbilical ArteriesUmbilical VeinsConceptsAdverse outcome parametersAdverse perinatal outcomesGrowth-restricted fetusesOutcome parametersApgar scorePerinatal outcomesDuctus venosusPerinatal deathNeonatal intensive care unitSevere intrauterine growth restrictionDuctus venosus Doppler velocimetryAbnormal Doppler velocimetryVenous Doppler velocimetryVenous Doppler waveformsRespiratory distress syndromeMiddle cerebral arteryRetinopathy of prematurityIntensive care unitIntrauterine growth restrictionDays of lifeOnly significant parameterApgar valuesPeriventricular leukomalaciaDistress syndromeFetal demiseNew triple screen test for Down syndrome: Combined urine analytes and serum AFP
Bahado‐Singh R, Oz U, Kovanci E, Cermik D, Flores D, Copel J, Mahoney M, Cole L. New triple screen test for Down syndrome: Combined urine analytes and serum AFP. The Journal Of Maternal-Fetal Medicine 1998, 7: 111-114. PMID: 9642606, DOI: 10.1002/(sici)1520-6661(199805/06)7:3<111::aid-mfm2>3.0.co;2-n.Peer-Reviewed Original ResearchConceptsSerum AFPIndividual Down syndrome oddsMaternal ageTriple screenUrine beta-core fragmentDown syndromeTriple testTriple screen testBeta-core fragmentDown syndrome casesNeural tube defectsDown's syndrome likelihood ratiosEstriol levelsLarge trialsSecond trimesterUrine testsPositive rateEstriol ratioSyndrome casesTube defectsScreen testFalse positive rateAFP dataUrine analytesAFPDual Roles of Amniotic Fluid Nitric Oxide and Prostaglandin E2 in Preterm Labor with Intra-Amniotic Infection
Hsu C, Meaddough E, Aversa K, Hong S, Lee I, Bahodo-Singh R, Lu L, Copel J. Dual Roles of Amniotic Fluid Nitric Oxide and Prostaglandin E2 in Preterm Labor with Intra-Amniotic Infection. American Journal Of Perinatology 1998, 15: 683-687. PMID: 10333395, DOI: 10.1055/s-2007-999302.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionNitric oxide metabolitesPreterm labor patientsAmniotic fluid nitric oxide metabolitesProstaglandin E2Preterm laborLabor patientsNitric oxideIntraamniotic infectionAmniotic fluidAmniotic fluid nitric oxidePositive amniotic fluid cultureAmniotic fluid creatinineProinflammatory nitric oxidePro-inflammatory nitric oxideAmniotic fluid concentrationsAmniotic fluid levelsNitric oxide synthaseCyclo-oxygenase-2Amniotic fluid cultureEnzyme-linked immunoassayOxide metabolitesLeukocyte countFluid cultureOxide synthase
1997
Fetal transcerebellar diameter in Down syndrome.
Rotmensch S, Goldstein I, Liberati M, Shalev J, Ben-Rafael Z, Copel J. Fetal transcerebellar diameter in Down syndrome. Obstetrics And Gynecology 1997, 89: 534-7. PMID: 9083308, DOI: 10.1016/s0029-7844(97)00076-8.Peer-Reviewed Original Research
1995
Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results
Bahado-Singh R, Goldstein I, Uerpairojkit B, Copel J, Mahoney M, Baumgarten A. Normal nuchal thickness inthe midtrimester indicates reduced risk of Down syndrome in pregnancies with abnormal triple-screen results. American Journal Of Obstetrics And Gynecology 1995, 173: 1106-1110. PMID: 7485301, DOI: 10.1016/0002-9378(95)91334-3.Peer-Reviewed Original ResearchConceptsAbnormal triple-screen resultsTriple-screen resultsNuchal thicknessDown syndromeHuman chorionic gonadotropin levelsNuchal thickness measurementChorionic gonadotropin levelsReceiver operator characteristic curveNumber of amniocentesesReceiver operator characteristic plotsRisk thresholdMidtrimester pregnancyGonadotropin levelsWeeks' gestationMaternal ageConsecutive fetusesUnconjugated estriolSerum screeningEuploid fetusesAlpha-fetoproteinSyndromeTrisomy 21Screen resultsRisk estimatesFetusesThe predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization
Moise K, Perkins J, Sosler S, Brown S, Saade G, Carpenter R, Thorp J, Ludomirski A, Wilkins I, Grannum P, Copel J. The predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization. American Journal Of Obstetrics And Gynecology 1995, 172: 1003-1009. PMID: 7892839, DOI: 10.1016/0002-9378(95)90034-9.Peer-Reviewed Original ResearchConceptsRed blood cell alloimmunizationFetal anemiaMarsh scoreReceiver operator characteristic curveCoombs titersRed blood cell antibodiesMaternal antibody titersGroups of fetusesMaternal serum testingCharacteristic curveMaternal serum testsMaternal titersCell antibodiesAntigen statusGestational agePregnant womenAntibody titersSerum testingSerum testFetal hematocritInvasive testingFetal bloodKruskal-Wallis testAnemiaFetal disease
1993
Ultrasound screening for fetal structural anomalies
Gomez K, Copel J. Ultrasound screening for fetal structural anomalies. Current Opinion In Obstetrics & Gynecology 1993, 5: 204-210. PMID: 8490090, DOI: 10.1097/00001703-199304000-00006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFetal structural anomaliesStructural anomaliesRoutine ultrasound screeningFour-chamber viewNeural tube defectsRoutine ultrasoundUltrasound screeningHigh riskUltrasound prenatal diagnosisTube defectsUltrasoundPregnancyPrenatal diagnosisDiagnostic ultrasoundControversial topicPatientsObstetricsFetusesAmniocentesisDiagnosis
1992
Fetuses with Down syndrome have disproportionately shortened frontal lobe dimensions on ultrasonographic examination
Bahado-Singh R, Wyse L, Dorr M, Copel J, O'Connor T, Hobbins J. Fetuses with Down syndrome have disproportionately shortened frontal lobe dimensions on ultrasonographic examination. American Journal Of Obstetrics And Gynecology 1992, 167: 1009-1014. PMID: 1415385, DOI: 10.1016/s0002-9378(12)80029-9.Peer-Reviewed Original ResearchMeSH KeywordsDown SyndromeFemaleFrontal LobeGestational AgeHumansMathematicsPregnancyPregnancy Trimester, SecondSensitivity and SpecificityThalamusUltrasonography, PrenatalConceptsDown syndrome fetusesSyndrome fetusesFrontothalamic distanceDown syndromePositive predictive valueWeeks' gestationGestational ageNormal medianPosterior thalamusUltrasonographic examinationGroup 52Normal fetusesFrontal lobePredictive valueInner tableFetusesFrontal boneMedianGestationMean valueSyndrome