1999
Thrombomodulin: A New Marker for Placental Abruption
Magriples U, Chan D, Bruzek D, Copel J, Hsu C. Thrombomodulin: A New Marker for Placental Abruption. Thrombosis And Haemostasis 1999, 81: 32-34. PMID: 9974370, DOI: 10.1055/s-0037-1614413.Peer-Reviewed Original ResearchConceptsPlacental abruptionAcute placental abruptionAbnormal coagulation profileProspective cohort studyEndothelial cell damageCohort studyCoagulation profilePathologic evidencePregnant womenKleihauer-BetkeAbruptionGroup 2Group 1Placental syncytiotrophoblastClinical diagnosisThrombomodulinCell damageSpecific markersNew markersPatientsMarkersDeliverySyncytiotrophoblastDiagnosisWomenA high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age
Bahado-Singh R, Oz U, Kovanci E, Cermik D, Copel J, Mahoney M, Cole L. A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age. American Journal Of Obstetrics And Gynecology 1999, 180: 169-173. PMID: 9914599, DOI: 10.1016/s0002-9378(99)70170-5.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageNuchal thicknessMaternal ageGenetic amniocentesisDown syndrome detection rateUrinary beta-core fragmentUrinary analytesMaternal age-related riskRisk thresholdSyndrome detection rateTotal study populationHigh-risk groupAge-related riskBeta-core fragmentRate of amniocentesisHuman chorionic gonadotropinDown syndrome riskDown's syndrome likelihood ratiosDown's syndrome screening efficiencyLikelihood ratioCommon indicationFalse positive rateNormal medianPregnant womenSyndrome riskNitric Oxide: A Clinically Important Amniotic Fluid Markerto Distinguish Between Intra-Amniotic Mycoplasma and Non-Mycoplasma Infections
Hsu C, Aversa K, Lu L, Meaddough E, Jones D, Bahado-Singh R, Copel J, Lee I. Nitric Oxide: A Clinically Important Amniotic Fluid Markerto Distinguish Between Intra-Amniotic Mycoplasma and Non-Mycoplasma Infections. American Journal Of Perinatology 1999, 16: 161-166. PMID: 10458527, DOI: 10.1055/s-2007-993851.Peer-Reviewed Original ResearchConceptsAmniotic fluid testsIntra-amniotic infectionInterleukin-6Mycoplasma infectionLeukocyte countFluid testsAmniotic fluid creatinine levelsAmniotic fluid glucose levelNitric oxide metabolite concentrationsPositive amniotic fluid cultureInterleukin-6 concentrationsManagement of patientsAmniotic fluid concentrationsAmniotic fluid leukocyte countsAmniotic fluid cultureClinical characteristicsCreatinine levelsPregnant womenClinical managementFluid cultureGlucose levelsClinical importanceUseful markerGriess reagentInfection
1998
Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection
Hsu C, Meaddough E, Aversa K, Hong S, Lu L, Jones D, Copel J. Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection. American Journal Of Obstetrics And Gynecology 1998, 179: 1267-1270. PMID: 9822513, DOI: 10.1016/s0002-9378(98)70144-9.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionAmniotic fluid levelsLeukemia inhibitory factorInterleukin-6Interleukin-8Fluid levelsInhibitory factorCreatinine levelsPregnant womenPositive amniotic fluid culture resultsAmniotic fluid creatinine levelsElevated amniotic fluid levelsAmniotic fluid culture resultsAmniotic fluid testsEnzyme-linked immunoassayPreterm contractionsPremature rupturePrognostic importanceLeukocyte countSignificant elevationAmniotic fluidMedian levelsCulture resultsInfectionGram stainGlycosylated Hemoglobin in Insulin-Dependent Diabetes Mellitus Related to Preeclampsia
Hsu C, Hong S, Nickless N, Copel J. Glycosylated Hemoglobin in Insulin-Dependent Diabetes Mellitus Related to Preeclampsia. American Journal Of Perinatology 1998, 15: 199-202. PMID: 9572378, DOI: 10.1055/s-2007-993926.Peer-Reviewed Original ResearchConceptsIDDM pregnant womenMean HbA1c valuesIncidence of preeclampsiaHbA1c valuesPregnant womenGestational periodExact testInsulin-dependent diabetes mellitusHigher mean HbA1cPathogenesis of preeclampsiaWeeks of gestationFisher's exact testDifferent gestational periodsNormal mean valueIDDM pregnanciesMean HbA1cDiabetes mellitusWeeks' gestationGlycosylated hemoglobinInsulin-DependentRetrospective studyTrophoblastic invasionMedical recordsPreeclampsiaHigh incidenceThe role of amniotic fluid L-selectin, GRO-α, and interleukin-8 in the pathogenesis of intraamniotic infection
Hsu C, Meaddough E, Aversa K, Copel J. The role of amniotic fluid L-selectin, GRO-α, and interleukin-8 in the pathogenesis of intraamniotic infection. American Journal Of Obstetrics And Gynecology 1998, 178: 428-432. PMID: 9539502, DOI: 10.1016/s0002-9378(98)70414-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidCarboxylic Ester HydrolasesChemokine CXCL1ChemokinesChemokines, CXCChemotactic FactorsCreatinineFemaleGlucoseGrowth SubstancesHumansInfectionsIntercellular Signaling Peptides and ProteinsInterleukin-8Leukocyte CountL-SelectinPregnancyStatistics, NonparametricConceptsSoluble L-selectinIntraamniotic infectionAmniotic fluid levelsInterleukin-8L-selectinPregnant womenRank correlation testFluid levelsAmniotic fluid creatinine levelsPositive amniotic fluid cultureAmniotic fluid glucose concentrationAmniotic fluid leukocytesRupture of membranesAmniotic fluid leukocyte countsMann-Whitney UtestAmniotic fluid testsPotent leukocyte chemoattractantLeukocyte esterase activityAmniotic fluid cultureEnzyme-linked immunoassayPreterm contractionsCreatinine levelsSpearman rank correlation testLeukocyte countFluid culture
1997
Elevated amniotic fluid nitric oxide metabolites and cyclic guanosine 3′,5′-monophosphate in pregnant women with intraamniotic infection
Hsu C, Aversa K, Meaddough E, Lee I, Copel J. Elevated amniotic fluid nitric oxide metabolites and cyclic guanosine 3′,5′-monophosphate in pregnant women with intraamniotic infection. American Journal Of Obstetrics And Gynecology 1997, 177: 793-796. PMID: 9369821, DOI: 10.1016/s0002-9378(97)70270-9.Peer-Reviewed Original ResearchConceptsAmniotic fluid nitric oxide metabolitesNitric oxide metabolitesCyclic guanosine monophosphateIntraamniotic infectionOxide metabolitesPregnant womenLeukocyte esterase activityGuanosine monophosphateLeukocyte countAmniotic fluid nitric oxidePositive amniotic fluid cultureAmniotic fluid glucose concentrationCyclic guanosineCyclic guanosine monophosphate levelsAmniotic fluid levelsRupture of membranesAmniotic fluid Gram stainAmniotic fluid leukocyte countsGuanosine monophosphate levelsAmniotic fluid culturePanel of testsPreterm contractionsEndogenous nitriteFluid cultureFluid levelsIs Maternal Thyrotropin Releasing Hormone Administration Safe in the Pregnant Woman with Preeclampsia?
Tan A, Hsu C, Marder S, Copel J. Is Maternal Thyrotropin Releasing Hormone Administration Safe in the Pregnant Woman with Preeclampsia? American Journal Of Perinatology 1997, 14: 5-6. PMID: 9259888, DOI: 10.1055/s-2007-994087.Peer-Reviewed Original Research
1995
Thrombomodulin levels in preeclampsia, gestational hypertension, and chronic hypertension.
Hsu C, Copel J, Hong S, Chan D. Thrombomodulin levels in preeclampsia, gestational hypertension, and chronic hypertension. Obstetrics And Gynecology 1995, 86: 897-9. PMID: 7501335, DOI: 10.1016/0029-7844(95)00326-m.Peer-Reviewed Original ResearchConceptsChronic hypertensionGestational hypertensionThrombomodulin levelsSerum thrombomodulin levelsSoluble thrombomodulin antigenNormotensive control groupTwo-site enzyme-linked immunosorbentLevels of thrombomodulinNormotensive pregnant womenEnzyme-linked immunosorbentACOG criteriaHypertensive disordersSerum levelsThird trimesterNormotensive controlsPregnant womenHypertensionPreeclampsiaThrombomodulin antigenControl groupThrombomodulinWomenSignificant differencesMeaningful markersTrimesterThe predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization
Moise K, Perkins J, Sosler S, Brown S, Saade G, Carpenter R, Thorp J, Ludomirski A, Wilkins I, Grannum P, Copel J. The predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization. American Journal Of Obstetrics And Gynecology 1995, 172: 1003-1009. PMID: 7892839, DOI: 10.1016/0002-9378(95)90034-9.Peer-Reviewed Original ResearchConceptsRed blood cell alloimmunizationFetal anemiaMarsh scoreReceiver operator characteristic curveCoombs titersRed blood cell antibodiesMaternal antibody titersGroups of fetusesMaternal serum testingCharacteristic curveMaternal serum testsMaternal titersCell antibodiesAntigen statusGestational agePregnant womenAntibody titersSerum testingSerum testFetal hematocritInvasive testingFetal bloodKruskal-Wallis testAnemiaFetal disease
1994
Growth of the fetal gall bladder in normal pregnancies
Goldstein I, Tamir A, Weisman A, Jakobi P, Copel J. Growth of the fetal gall bladder in normal pregnancies. Ultrasound In Obstetrics And Gynecology 1994, 4: 289-293. PMID: 12797163, DOI: 10.1046/j.1469-0705.1994.04040289.x.Peer-Reviewed Original ResearchFetal gall bladderGestational ageGall bladderAbdominal circumferenceBiparietal diameterBladder areaFirst-degree correlationGall-bladder areaFemoral lengthNormal pregnant womenBiliary duct systemSignificant correlationRoutine biometric measurementsNormative dataBladder circumferenceNormal pregnancyWeeks' gestationPregnant womenAdditional lesionsStudy groupBladderCircumferenceLong bonesAgeFurther studies