Chronic Chikungunya Arthritis and Rheumatoid Arthritis: What They Have in Common
Amaral JK, Bilsborrow JB, Schoen RT. Chronic Chikungunya Arthritis and Rheumatoid Arthritis: What They Have in Common. The American Journal Of Medicine 2019, 133: e91-e97. PMID: 31705850, PMCID: PMC7385732, DOI: 10.1016/j.amjmed.2019.10.005.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisChikungunya arthritisRheumatoid arthritisChikungunya virusAcute febrile illnessAcute illnessFebrile illnessHigh feverInflammatory arthritisMaculopapular rashAcute infectionInfectious causesClinical manifestationsInflammatory processChikungunya feverArthritisFamily TogaviridaeGenus AlphavirusPatientsFeverBetter diagnosisIllnessSignificant proportionRNA virusesVirusMacrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus
Bilsborrow JB, Doherty E, Tilstam PV, Bucala R. Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus. Expert Opinion On Therapeutic Targets 2019, 23: 733-744. PMID: 31414920, PMCID: PMC6800059, DOI: 10.1080/14728222.2019.1656718.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorSystemic lupus erythematosusRheumatoid arthritisMigration inhibitory factorLupus erythematosusMIF inhibitorsMIF inhibitionAutoimmune diseasesRole of MIFInhibitory factorPathogenesis of RARefractory autoimmune diseasesHigh expressionPleiotropic inflammatory cytokineClinical trial dataPrecision medicine approachGlucocorticoid dependenceInflammatory cytokinesAdaptive immunityTherapeutic targetClinical developmentSmall molecule inhibitorsTrial dataTherapeutic potentialErythematosus