Featured Publications
Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney
Chaurasia R, Salovey A, Guo X, Desir G, Vinetz JM. Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney. Frontiers In Cellular And Infection Microbiology 2022, 12: 926994. PMID: 35837473, PMCID: PMC9274288, DOI: 10.3389/fcimb.2022.926994.Peer-Reviewed Original ResearchConceptsLethal challenge infectionChallenge infectionBacterial loadC3H/HeJ miceKey target organClinical pathogenesisSevere leptospirosisOrgan infectionProtein immunizationHeJ miceSerovar CanicolaTarget organsAnimal modelsLeptospirosis pathogenesisCellular pathogenesisMicePathogenesisInfectionLeptospira interrogansVirulence factorsModifying proteinsImmunizationKidneyLeptospirosisLiver
2005
A global research agenda for leptospirosis.
Cachay E, Vinetz J. A global research agenda for leptospirosis. Journal Of Postgraduate Medicine 2005, 51: 174-8. PMID: 16333188, PMCID: PMC2270399.Peer-Reviewed Original ResearchConceptsImpact of leptospirosisVaccine-induced protective immunityEffective adjunct treatmentPublic health effortsAdjunct treatmentProtective immunityClinical leptospirosisHealth research fundingHealth effortsLeptospirosis pathogenesisAppropriate mobilizationSpirochetal diseasesLeptospirosisLeptospirosis transmissionCollaborative international effortDiseaseMammalian reservoirsTreatmentHealthVeterinary healthMorbidityRural areasPathogenesisGlobal research agendaMortality