2024
Evaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax
Cao Y, Hayashi C, Araujo M, Tripathi A, Andrade A, Medeiros J, Vinetz J, Kumar N. Evaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax. Vaccine 2024, 42: 126140. PMID: 39033079, PMCID: PMC11338703, DOI: 10.1016/j.vaccine.2024.07.041.Peer-Reviewed Original ResearchDirect membrane feeding assaysTransmission-reducing activityStandard membrane feeding assayMembrane feeding assaysP. vivaxDNA vaccineP. falciparumPlasmodium falciparumTransmission of Plasmodium falciparumAntibody responseDNA vaccine platformP. vivax accountsGlobal malaria burdenTransmission-blocking activityTransmission of malariaCombination of DNA vaccineIn vivo electroporationCombined DNA vaccineMalaria burdenMalaria transmissionTransmission-blockingAssess immunogenicityVaccine platformClinical studiesCombination groupEffect of spatiotemporal variables on abundance, biting activity and parity of Nyssorhynchus darlingi (Diptera: Culicidae) in peri-Iquitos, Peru
Bickersmith S, Saavedra M, Prussing C, Lange R, Morales J, Alava F, Vinetz J, Gamboa D, Moreno M, Conn J. Effect of spatiotemporal variables on abundance, biting activity and parity of Nyssorhynchus darlingi (Diptera: Culicidae) in peri-Iquitos, Peru. Malaria Journal 2024, 23: 112. PMID: 38641572, PMCID: PMC11031940, DOI: 10.1186/s12936-024-04940-z.Peer-Reviewed Original ResearchConceptsMalaria transmissionBreeding site availabilityPresence of Plasmodium vivaxDry seasonBiting behaviorRisk of malaria transmissionMalaria-endemic regionsHuman malaria casesPlasmodium falciparum sporozoitesRainy seasonCommunity typesNyssorhynchus darlingiRates of parityReal-time PCRAmazonian PeruP. vivaxMalaria casesPlasmodium vivaxHuman landing catchesP. falciparumEffect of seasonMosquito behaviorConclusionsThese dataDaily survivalDarlingi
2023
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi
Andrade A, Santos N, Bastos A, Pontual J, Araújo J, Silva A, Martinez L, Lima A, Aguiar A, Teles C, Medeiros J, Pereira D, Vinetz J, Gazzinelli R, Araújo M. Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. PLOS Neglected Tropical Diseases 2023, 17: e0011425. PMID: 37327209, PMCID: PMC10310017, DOI: 10.1371/journal.pntd.0011425.Peer-Reviewed Original ResearchConceptsDensity of gametocytesTransmission-blocking efficacyPlasmodium vivax malariaTransmission-blocking activityImportant infectious diseasesOne-doseVivax malariaP. vivaxMosquito infectionPlasmodium vivaxTreatment groupsPatient's bloodGametocyte productionMalaria transmissionInfectious diseasesGenus PlasmodiumMalariaTreatmentChloroquinePrimaquineVivaxBloodDirect membraneBiological characteristicsMosquitoes
2022
Malaria transmission structure in the Peruvian Amazon through antibody signatures to Plasmodium vivax
Rosado J, Carrasco-Escobar G, Nolasco O, Garro K, Rodriguez-Ferruci H, Guzman-Guzman M, Llanos-Cuentas A, Vinetz JM, Nekkab N, White MT, Mueller I, Gamboa D. Malaria transmission structure in the Peruvian Amazon through antibody signatures to Plasmodium vivax. PLOS Neglected Tropical Diseases 2022, 16: e0010415. PMID: 35533146, PMCID: PMC9119515, DOI: 10.1371/journal.pntd.0010415.Peer-Reviewed Original ResearchConceptsSerological exposure markersP. vivaxMalaria transmissionAntibody levelsRecent exposureRoutine malaria surveillanceHigher antibody levelsCross-sectional surveyLight microscopySeropositive casesAntibody signaturesPast infectionRisk factorsPrevalence surveyHigher oddsMalaria surveillanceExposure markersElimination effortsSignificant associationSocio-DemographicEpidemiological analysisSerological surveillanceParticular epidemiologyLocal transmissionVivax
2021
Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi
Almeida GG, Costa PAC, da Silva Araujo M, Gomes GR, Carvalho AF, Figueiredo MM, Pereira DB, Tada MS, Medeiros JF, da Silva Soares I, Carvalho LH, Kano FS, de Castro M, Vinetz JM, Golenbock DT, do Valle Antonelli L, Gazzinelli RT. Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi. PLOS Neglected Tropical Diseases 2021, 15: e0009077. PMID: 34714821, PMCID: PMC8555776, DOI: 10.1371/journal.pntd.0009077.Peer-Reviewed Original ResearchConceptsAsymptomatic individualsP. vivaxP. vivax malaria patientsP. vivax infectionVivax malaria patientsPlasmodium vivax malariaLow endemicity areaMalaria patientsSymptomatic patientsAsymptomatic infectionVivax malariaVivax infectionInfectious reservoirLow parasitemiaUninfected controlsEndemic regionsMalaria transmissionInfectivity ratesMalaria parasitesBiochemical parametersParasitemiaBloodPotential rolePatientsInfectionHeterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts
Rosado J, White MT, Longley RJ, Lacerda M, Monteiro W, Brewster J, Sattabongkot J, Guzman-Guzman M, Llanos-Cuentas A, Vinetz JM, Gamboa D, Mueller I. Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. PLOS Neglected Tropical Diseases 2021, 15: e0009165. PMID: 33591976, PMCID: PMC7909627, DOI: 10.1371/journal.pntd.0009165.Peer-Reviewed Original ResearchConceptsSerological exposure markersBlood-stage infectionLow transmission settingsP. vivax infectionPlasmodium vivax infectionHigh transmission settingsVivax infectionTransmission settingsAntibody titersAntibody responseExposure markersDifferent transmission intensitiesIgG responsesSerological markersPrevious infectionReceiver Operating Characteristic (ROC) analysisEndemic settingsMalaria eliminationPeruvian cohortOperating characteristics analysisP. vivaxMalaria controlRecent exposureInfectionEpidemiological context
2016
Epidemiology of Plasmodium vivax Malaria in Peru
Rosas-Aguirre A, Gamboa D, Manrique P, Conn JE, Moreno M, Lescano AG, Sanchez JF, Rodriguez H, Silva H, Llanos-Cuentas A, Vinetz JM. Epidemiology of Plasmodium vivax Malaria in Peru. American Journal Of Tropical Medicine And Hygiene 2016, 95: 133-144. PMID: 27799639, PMCID: PMC5201219, DOI: 10.4269/ajtmh.16-0268.Peer-Reviewed Original ResearchConceptsMalaria transmissionP. vivaxMalaria controlPlasmodium falciparum malaria casesMicroscopy-confirmed casesP. vivax malaria transmissionFalciparum malaria casesPlasmodium vivax malariaVivax malaria transmissionPublic health problemGlucose-6-phosphate dehydrogenase deficiencyFuture malaria controlImplementation of surveillanceCombination therapyVivax malariaClinical trialsMalaria casesPlasmodium vivaxElimination effortsHealth problemsP. falciparumMosquito transmissionDehydrogenase deficiencyVivaxOngoing surveillance activities
2006
314 EXPERIMENTAL INFECTION OF ANOPHELES DARLINGI MOSQUITOES BY PLASMODIUM VIVAX FROM NATURALLY INFECTED PATIENTS IN THE PERUVIAN AMAZON.
Bharti A, Chuquiyauri R, Segura E, Lopez V, Stancil J, Llanos A, Vinetz J. 314 EXPERIMENTAL INFECTION OF ANOPHELES DARLINGI MOSQUITOES BY PLASMODIUM VIVAX FROM NATURALLY INFECTED PATIENTS IN THE PERUVIAN AMAZON. Journal Of Investigative Medicine 2006, 54: s134. DOI: 10.2310/6650.2005.x0004.313.Peer-Reviewed Original ResearchP. vivaxPlasmodium vivaxP. vivax infectionIncidence of malariaLife-threatening diseaseTransmission of infectionOocyst loadMembrane feeding techniqueSymptomatic patientsArtificial membrane feeding techniqueVivax malariaVivax infectionInterventional methodsPatientsInfected mosquitoesExperimental infectionDarlingi mosquitoesMosquito midgutVivaxAlternative interventionsInfectionMicroscopic examinationCurrent control measuresInfected midgutsMalaria