Featured Publications
Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney
Chaurasia R, Salovey A, Guo X, Desir G, Vinetz JM. Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney. Frontiers In Cellular And Infection Microbiology 2022, 12: 926994. PMID: 35837473, PMCID: PMC9274288, DOI: 10.3389/fcimb.2022.926994.Peer-Reviewed Original ResearchConceptsLethal challenge infectionChallenge infectionBacterial loadC3H/HeJ miceKey target organClinical pathogenesisSevere leptospirosisOrgan infectionProtein immunizationHeJ miceSerovar CanicolaTarget organsAnimal modelsLeptospirosis pathogenesisCellular pathogenesisMicePathogenesisInfectionLeptospira interrogansVirulence factorsModifying proteinsImmunizationKidneyLeptospirosisLiverDemographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri Lanka
Agampodi S, Warnasekara J, Siribaddana S, Kularatna S, Gamage C, Jayasundara D, Senevirathna I, Srimantha S, Kappagoda C, Weerawansa P, Pilapitiya S, Lokunarangoda N, Sarathchandra C, Senanayake H, Matthias M, Vinetz J. Demographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri Lanka. Data In Brief 2022, 43: 108378. PMID: 35770027, PMCID: PMC9234077, DOI: 10.1016/j.dib.2022.108378.Peer-Reviewed Original Research
2022
Culture-Independent Detection and Identification of Leptospira Serovars
Matthias M, Lubar A, Acharige S, Chaiboonma K, Pilau N, Marroquin A, Jayasundara D, Agampodi S, Vinetz J. Culture-Independent Detection and Identification of Leptospira Serovars. Microbiology Spectrum 2022, 10: e02475-22. PMID: 36445143, PMCID: PMC9769591, DOI: 10.1128/spectrum.02475-22.Peer-Reviewed Original ResearchConceptsPublic health importanceProspective studyFatal diseaseHealth importanceOutbreak investigationSequence typingDog urine samplesCulture-independent assaysEnvironmental surveillance studyMultilocus sequence typingPulsed-field gel electrophoresisSurveillance studyGroup IIHuman leptospirosisPrognostic testSpecific real-time qPCRClinical settingGroup ILeptospira serovarsReal-time qPCRDiagnostic testsSerum samplesUrine samplesDiagnostic specificityLeptospirosisSerological and molecular epidemiology of leptospirosis and the role of dogs as sentinel for human infection in Nigeria
Pilau NN, Lubar AA, Daneji AI, Mera UM, Magaji AA, Abiayi EA, Chaiboonma KL, Busayo EI, Vinetz JM, Matthias MA. Serological and molecular epidemiology of leptospirosis and the role of dogs as sentinel for human infection in Nigeria. Heliyon 2022, 8: e09484. PMID: 35647333, PMCID: PMC9136256, DOI: 10.1016/j.heliyon.2022.e09484.Peer-Reviewed Original ResearchProspective cross-sectional studyCarriers of leptospiresCross-sectional studySymptomatic dogsQuantitative real-time PCRRole of dogsBacteriological prevalenceReal-time PCRUnvaccinated animalsHigh riskLeptospiral infectionInfection rateHuman infectionsPublic health riskMolecular epidemiologyStray dogsInfectionDogsCulture isolationO-antigen regionHealth risksLeptospirosisLipopolysaccharideSerogroupsStrong determinant
2020
79 Leptospirosis
Vinetz J, Watt G. 79 Leptospirosis. 2020, 636-640. DOI: 10.1016/b978-0-323-55512-8.00079-x.Peer-Reviewed Original ResearchSevere leptospirosisAcute kidney injuryEndothelial cell dysfunctionKey pathologic featuresThird-generation cephalosporinsMarked functional impairmentHigh mortality ratePathogenesis of leptospirosisMost disease transmissionRefractory shockKidney injuryOral doxycyclineParenteral penicillinPulmonary hemorrhageSubstantial morbidityPathologic featuresHistopathologic changesFunctional impairmentAvailable vaccinesCell dysfunctionDiagnostic confirmationRisk populationsMilder casesMortality rateLeptospirosis
2005
A global research agenda for leptospirosis.
Cachay E, Vinetz J. A global research agenda for leptospirosis. Journal Of Postgraduate Medicine 2005, 51: 174-8. PMID: 16333188, PMCID: PMC2270399.Peer-Reviewed Original ResearchConceptsImpact of leptospirosisVaccine-induced protective immunityEffective adjunct treatmentPublic health effortsAdjunct treatmentProtective immunityClinical leptospirosisHealth research fundingHealth effortsLeptospirosis pathogenesisAppropriate mobilizationSpirochetal diseasesLeptospirosisLeptospirosis transmissionCollaborative international effortDiseaseMammalian reservoirsTreatmentHealthVeterinary healthMorbidityRural areasPathogenesisGlobal research agendaMortality
2001
Leptospirosis
Vinetz J. Leptospirosis. Current Opinion In Infectious Diseases 2001, 14: 527-538. PMID: 11964872, DOI: 10.1097/00001432-200110000-00005.Peer-Reviewed Original ResearchConceptsPopulation-based studyViral hemorrhagic feverImportant zoonotic diseasePulmonary hemorrhageFebrile syndromeLethal complicationTyphoid vaccineClinical expressionLeptospiral geneHemorrhagic feverLeptospirosis vaccineInfectious diseasesLeptospirosisLeptospira spDiseaseVaccineZoonotic diseaseMammalian reservoir hostsLeptospiral strainsRecent reportsLeptospira genomeReservoir hostsPoor correlationComplicationsHemorrhage