2022
Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke
Yuen MM, Prabhat AM, Mazurek MH, Chavva IR, Crawford A, Cahn BA, Beekman R, Kim JA, Gobeske KT, Petersen NH, Falcone GJ, Gilmore EJ, Hwang DY, Jasne AS, Amin H, Sharma R, Matouk C, Ward A, Schindler J, Sansing L, de Havenon A, Aydin A, Wira C, Sze G, Rosen MS, Kimberly WT, Sheth KN. Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke. Science Advances 2022, 8: eabm3952. PMID: 35442729, PMCID: PMC9020661, DOI: 10.1126/sciadv.abm3952.Peer-Reviewed Original ResearchIschemic strokeMagnetic resonance imagingResonance imagingFluid-attenuated inversion recoveryDiffusion-weighted imaging sequencesStroke volume measurementsStroke pathwayStroke severityFunctional outcomeLow-field magnetic resonance imagingBedside evaluationClinical managementStroke volumeMRI studiesStrokePatientsBrain imagingCerebellar structuresHigh-field MRI studiesHyperintense regionsInversion recoveryInfarctsUseful imagingVolume measurements
2021
Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study
Peng TJ, Jasne AS, Simonov M, Abdelhakim S, Kone G, Cheng YK, Rethana M, Tarasaria K, Herman AL, Baker AD, Yaghi S, Frontera JA, Sansing LH, Falcone GJ, Spudich S, Schindler J, Sheth KN, Sharma R. Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study. Frontiers In Neurology 2021, 12: 741044. PMID: 34675873, PMCID: PMC8524436, DOI: 10.3389/fneur.2021.741044.Peer-Reviewed Original ResearchAcute ischemic strokeHospitalized COVID-19 patientsCOVID-19 patientsCOVID-19 cohortNeurologic symptomsPrior strokeIschemic strokeAIS patientsDerivation cohortControl cohortRisk of AISMultivariable logistic regression modelIschemic stroke riskCOVID-19 severityYale New Haven HealthLogistic regression modelsHospital presentationIndependent predictorsStroke riskMajor health systemsHigh riskPatientsYounger ageCohortStrokeDrip-and-ship versus mothership for endovascular treatment of acute stroke: A comparative effectiveness analysis
Wu X, Wira C, Matouk C, Forman H, Gandhi D, Sanelli P, Schindler J, Malhotra A. Drip-and-ship versus mothership for endovascular treatment of acute stroke: A comparative effectiveness analysis. International Journal Of Stroke 2021, 17: 315-322. PMID: 33759645, DOI: 10.1177/17474930211008701.Peer-Reviewed Original ResearchConceptsComprehensive stroke centerPrimary stroke centerAcute stroke patientsNearest comprehensive stroke centerAcute strokeMothership strategyStroke centersStroke patientsPlace of onsetHealth benefitsMarkov decision-analytic modelComparative effectiveness analysisRecent medical literatureMultiple sensitivity analysesDecision analytic modelMothership modelPrimary outcomeEndovascular treatmentPrehospital triageSudden onsetPatientsMedical literatureStrokeShip strategyTarget populationPrehospital Blood Pressure Reductions Are Associated with Neurologic Worsening in Patients With Large-vessel Occlusion Stroke (2844)
Kobsa J, Prasad A, Soto A, Kodali S, Nguyen C, Peshwe K, Orozco D, Farooqui M, Zevallos C, Sansing L, Schindler J, Matouk C, Sheth K, Ortega-Gutierrez S, Petersen N. Prehospital Blood Pressure Reductions Are Associated with Neurologic Worsening in Patients With Large-vessel Occlusion Stroke (2844). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2844.Peer-Reviewed Original Research
2020
Cost-effectiveness of endovascular thrombectomy in patients with acute stroke and M2 occlusion
Khunte M, Wu X, Payabvash S, Zhu C, Matouk C, Schindler J, Sanelli P, Gandhi D, Malhotra A. Cost-effectiveness of endovascular thrombectomy in patients with acute stroke and M2 occlusion. Journal Of NeuroInterventional Surgery 2020, 13: 784-789. PMID: 33077578, DOI: 10.1136/neurintsurg-2020-016765.Peer-Reviewed Original ResearchConceptsEndovascular thrombectomyMedical managementProbabilistic sensitivity analysesM2 occlusionsAcute strokeBranch occlusionEVT-treated patientsAcute ischemic strokeQuality-adjusted life yearsLifetime quality-adjusted life yearsDecision analytic modelDecision analytic studyIschemic strokeReperfusion techniquesLifetime horizonBetter outcomesPatientsLife yearsAge groupsPerfect healthSocietal perspectiveCost-effective strategyStrokeHealth benefitsOcclusionSpecial Populations
Amin H, Schindler J. Special Populations. 2020, 135-155. DOI: 10.1007/978-3-030-52552-1_11.ChaptersComplications of Stroke
Amin H, Schindler J. Complications of Stroke. 2020, 157-163. DOI: 10.1007/978-3-030-52552-1_12.ChaptersIntracranial Hemorrhage
Amin H, Schindler J. Intracranial Hemorrhage. 2020, 165-175. DOI: 10.1007/978-3-030-52552-1_13.ChaptersIntracranial hemorrhageCauses of ICHTreatment of ICHMost intracranial hemorrhagesSecondary preventionClinical presentationVascular neurologistsMild headacheVariable presentationDiagnostic evaluationBest treatmentHemorrhageNeurologistsHigh rateTreatmentPresentationHypertensionMorbidityHeadachePatientsStrokeMortalityNeurosurgeonsHematologic Disorders
Amin H, Schindler J. Hematologic Disorders. 2020, 193-201. DOI: 10.1007/978-3-030-52552-1_15.ChaptersHematological conditionsStrong family historyHypercoagulable panelStroke therapeuticsIschemic strokeSecondary preventionStroke neurologistsYounger patientsAcute treatmentHypercoagulable conditionsHematologic disordersFamily historyHematological disordersClot formationCoagulation cascadeStrokePatientsDisordersNeurologistsPreventionPharmacology
Amin H, Schindler J. Pharmacology. 2020, 235-241. DOI: 10.1007/978-3-030-52552-1_19.ChaptersConcomitant medical comorbiditiesManagement of patientsStroke therapeuticsMedical comorbiditiesAcute strokeSecondary preventionCerebrovascular diseaseVascular neurologistsClinical indicationsPharmacological basisNeurologistsTherapeuticsHypertensionComorbiditiesHyperlipidemiaThrombosisOutpatientsPatientsInternistsCardiologistsStrokeDiseaseSeverityPreventionPharmacologyStroke Syndromes
Amin H, Schindler J. Stroke Syndromes. 2020, 31-47. DOI: 10.1007/978-3-030-52552-1_4.ChaptersEpidemiology and Risk Factors
Amin H, Schindler J. Epidemiology and Risk Factors. 2020, 49-55. DOI: 10.1007/978-3-030-52552-1_5.ChaptersRisk factorsStroke riskNon-modifiable risk factorsIndividual stroke riskSignificant global health burdenModifiable risk factorsGlobal health burdenPutative risk factorsStroke physiciansInsulin resistanceOutpatient settingHealth burdenFuture burdenStrokeBurdenRiskFactorsInternistsEpidemiologyPhysiciansTrialsClassification of Stroke
Amin H, Schindler J. Classification of Stroke. 2020, 67-83. DOI: 10.1007/978-3-030-52552-1_7.Peer-Reviewed Original ResearchVertebral Artery Stenosis
Brooks D, Schindler J. Vertebral Artery Stenosis. Current Treatment Options In Cardiovascular Medicine 2020, 22: 35. DOI: 10.1007/s11936-020-00832-y.Peer-Reviewed Original ResearchVertebral artery stenosisArtery stenosisEndovascular therapyAggressive risk factor controlExtracranial vertebral artery stenosisHigh-intensity statin therapyIntracranial vertebral artery stenosisSymptomatic vertebral artery stenosisDual antiplatelet therapyLipid-Lowering TherapyRisk factor controlLipid-lowering agentsRisk of strokeNovel lipid-lowering agentsAggressive initiationAntiplatelet therapyStatin therapyCommon conditionHigh riskStenosisMedical careTherapyNatural historyTherapy protocolsStrokeCT Angiography for Triage of Patients with Acute Minor Stroke: A Cost-effectiveness Analysis.
Wu X, Hughes DR, Gandhi D, Matouk CC, Sheth K, Schindler J, Wira C, Wintermark M, Sanelli P, Malhotra A. CT Angiography for Triage of Patients with Acute Minor Stroke: A Cost-effectiveness Analysis. Radiology 2020, 294: 580-588. PMID: 31934828, DOI: 10.1148/radiol.2019191238.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionAcute minor strokeBest medical managementMinor strokeCT angiographyMedical managementProbabilistic sensitivity analysesLower health benefitsImmediate thrombectomyHealth benefitsHealth outcomesVascular imagingAcute ischemic strokeMarkov decision-analytic modelWorse health outcomesImproved health outcomesDecision analytic modelNet monetary benefitIntravenous thrombolysisIschemic strokeYounger patientsThrombectomy strategyPatientsAngiographyStroke
2019
Management of Hyperlipidemia After Stroke
Brooks DC, Schindler JL. Management of Hyperlipidemia After Stroke. Current Treatment Options In Cardiovascular Medicine 2019, 21: 93. PMID: 31840196, DOI: 10.1007/s11936-019-0774-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsManagement of hyperlipidemiaKey therapeutic targetCardiovascular diseaseTherapeutic targetAggressive LDL-C reductionStroke risk reductionLDL-C reductionAtherosclerotic vascular diseaseAvailable treatment optionsGeneral cardiovascular diseaseRecent FindingsStatinsIschemic strokePCSK9 inhibitorsHemorrhagic strokeRisk modificationTreatment optionsVascular diseaseRecent trialsNovel agentsNew agentsMost subtypesHyperlipidemiaStrokePatientsDiseaseImplications of Achieving TICI 2b Versus TICI 3 Reperfusion in Patients With Ischemic Stroke: A Cost-Effectiveness Analysis
Wu X, Gandhi D, Matouk C, Schindler J, Hughes D, Forman H, Sanelli P, Malhotra A. Implications of Achieving TICI 2b Versus TICI 3 Reperfusion in Patients With Ischemic Stroke: A Cost-Effectiveness Analysis. Neurosurgery 2019, 66: 310-670. DOI: 10.1093/neuros/nyz310_670.Peer-Reviewed Original ResearchBlood Pressure Management Outside Individualized Limits of Autoregulation is Associated with Neurologic Deterioration and Worse Functional Outcomes in Patients with Large-Vessel Occlusion (LVO) Ischemic Stroke (S52.002)
Silverman A, Wang A, Strander S, Kodali S, Sansing L, Schindler J, Gilmore E, Sheth K, Petersen N. Blood Pressure Management Outside Individualized Limits of Autoregulation is Associated with Neurologic Deterioration and Worse Functional Outcomes in Patients with Large-Vessel Occlusion (LVO) Ischemic Stroke (S52.002). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.s52.002.Peer-Reviewed Original Research
2018
Safety Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage (P4.033)
Chu S, Sommaruga S, Hwang D, Dearborn J, Sansing L, Cord B, Samarth G, Petersen N, Gilmore E, Schindler J, Matouk C, Sheth K, Falcone G. Safety Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage (P4.033). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p4.033.Peer-Reviewed Original Research
2016
Intracranial Hemorrhage
Amin H, Schindler J. Intracranial Hemorrhage. 2016, 127-134. DOI: 10.1007/978-3-319-39605-7_13.ChaptersIntracranial hemorrhageCauses of ICHTreatment of ICHMost intracranial hemorrhagesSecondary preventionClinical presentationVascular neurologistsMild headacheVariable presentationDiagnostic evaluationBest treatmentHemorrhageNeurologistsHigh rateTreatmentPresentationHypertensionMorbidityHeadachePatientsStrokeMortalityNeurosurgeons