2023
Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials
Wallach J, Deng Y, Polley E, Dhruva S, Herrin J, Quinto K, Gandotra C, Crown W, Noseworthy P, Yao X, Jeffery M, Lyon T, Ross J, McCoy R. Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials. Clinical Trials 2023, 20: 689-698. PMID: 37589143, PMCID: PMC10843567, DOI: 10.1177/17407745231193137.Peer-Reviewed Original ResearchConceptsBaseline participant characteristicsParticipant characteristicsPrimary endpointSecondary endpointsTrial publicationsMajor adverse cardiovascular eventsPropensity score-matched participantsFirst major adverse cardiovascular eventAdverse cardiovascular eventsBaseline patient characteristicsNonfatal myocardial infarctionOptumLabs Data WarehouseElectronic health record dataRepresentative patient populationHealth record dataCardiovascular eventsClinical characteristicsPatient characteristicsPatient populationMyocardial infarctionExclusion criteriaDrug effectivenessTrialsRecord dataEndpoint
2022
Prolonged use of newly prescribed gabapentin after surgery
Bongiovanni T, Gan S, Finlayson E, Ross J, Harrison JD, Boscardin J, Steinman MA. Prolonged use of newly prescribed gabapentin after surgery. Journal Of The American Geriatrics Society 2022, 70: 3560-3569. PMID: 36000860, PMCID: PMC9771946, DOI: 10.1111/jgs.18005.Peer-Reviewed Original ResearchConceptsUse of gabapentinProlonged useOpioid useNon-opioid pain medicationsHigher Charlson comorbidity scoreOlder adultsPostoperative opioid prescribingProlonged opioid useCharlson comorbidity scoreLength of stayAdverse drug eventsTotal hip replacementLogistic regression modelsGabapentinoid useMore comorbiditiesComorbidity scoreGabapentin useOpioid prescribingOpioid prescriptionsDischarge dispositionEmergency surgeryPain medicationPatient characteristicsPrimary outcomeMultivariable analysis
2021
Unplanned hospital visits after ambulatory surgical care
Bongiovanni T, Parzynski C, Ranasinghe I, Steinman MA, Ross JS. Unplanned hospital visits after ambulatory surgical care. PLOS ONE 2021, 16: e0254039. PMID: 34283840, PMCID: PMC8291649, DOI: 10.1371/journal.pone.0254039.Peer-Reviewed Original ResearchConceptsUnplanned hospital visitsSame-day surgeryHospital visitsAmbulatory surgeryHealthcare costsDischarge care qualityHospital visit ratesNumber of comorbiditiesEmergency department visitsMajority of surgeriesAmbulatory surgical careSpecific patient populationsQuality's Healthcare CostMedicaid Services measuresPatient hospital visitsQuality of careType of procedureDepartment visitsHospital admissionPatient characteristicsOutpatient settingPatient populationProcedure typeSurgical careSurgical facilities
2019
Generic and Brand-Name Thyroid Hormone Drug Use Among Commercially Insured and Medicare Beneficiaries, 2007 Through 2016
Ross JS, Rohde S, Sangaralingham L, Brito JP, Choi L, Dutcher SK, Graham DJ, Jenkins MR, Lipska KJ, Mendoza M, Qiang Y, Wang Z, Wu Y, Yao X, Shah ND. Generic and Brand-Name Thyroid Hormone Drug Use Among Commercially Insured and Medicare Beneficiaries, 2007 Through 2016. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 2305-2314. PMID: 30690529, DOI: 10.1210/jc.2018-02197.Peer-Reviewed Original ResearchConceptsBrand-name useDrug useMedicare AdvantageThyroid hormone replacement therapyLarge administrative claims databaseBeneficiary populationAdministrative claims databaseHormone replacement therapyCertain patient characteristicsMedicare Part DPrescriber specialtyPatient characteristicsPrescriber characteristicsClaims databaseReplacement therapyGeneric levothyroxineWhite raceHealth plansOlder adultsHormone drugsInsurance coverageProduct useLevothyroxineNational dataPart D
2014
Hospital variation in risk-standardized hospital admission rates from US EDs among adults
Capp R, Ross JS, Fox JP, Wang Y, Desai MM, Venkatesh AK, Krumholz HM. Hospital variation in risk-standardized hospital admission rates from US EDs among adults. The American Journal Of Emergency Medicine 2014, 32: 837-843. PMID: 24881514, DOI: 10.1016/j.ajem.2014.03.033.Peer-Reviewed Original ResearchConceptsHospital admission ratesEmergency departmentAdmission ratesClinical characteristicsED visitsHospital factorsClinical factorsAdult ED visitsUS emergency departmentsHospital teaching statusCross-sectional analysisPatient characteristicsHospital admissionHospital variationPatientsTeaching statusHospitalED dataVisitsRepresentative sampleAdultsRural locationsAdmissionFactorsNational variations
2009
Use of Medicare and Department of Veterans Affairs Health Care by Veterans with Dementia: A Longitudinal Analysis
Zhu CW, Penrod JD, Ross JS, Dellenbaugh C, Sano M. Use of Medicare and Department of Veterans Affairs Health Care by Veterans with Dementia: A Longitudinal Analysis. Journal Of The American Geriatrics Society 2009, 57: 1908-1914. PMID: 19682132, PMCID: PMC3233990, DOI: 10.1111/j.1532-5415.2009.02405.x.Peer-Reviewed Original ResearchConceptsMedicare useDual usersGreater likelihoodVeterans Affairs (VA) health careUse of MedicareHigh-quality careMultiple comorbiditiesPatient characteristicsVascular dementiaHigh comorbidityMedicare claimsFunctional limitationsMale veteransNursing homesVA servicesAlzheimer's diseaseVeterans AffairsOlder agePrivate insuranceFormal diagnosisDementiaUse groupHealth careCareLess likelihood
2008
Appropriate proton pump inhibitor use among older adults: A retrospective chart review
George CJ, Korc B, Ross JS. Appropriate proton pump inhibitor use among older adults: A retrospective chart review. The American Journal Of Geriatric Pharmacotherapy 2008, 6: 249-254. PMID: 19161927, DOI: 10.1016/j.amjopharm.2008.12.001.Peer-Reviewed Original ResearchConceptsProton pump inhibitorsPPI useRetrospective chart reviewGeriatric practiceChart reviewUrban academic medical centerOlder adultsAcademic geriatric practiceCurrent prescriptionParticular patient characteristicsAdverse drug reactionsCommunity-dwelling adultsAcademic medical centerOutpatient geriatric practiceAmbulatory care practicesPPI initiationMore medicationsMultiple comorbiditiesGastroenterology guidelinesInhibitor usePatient characteristicsNonwhite raceMean agePump inhibitorsDrug reactionsStatistical Models and Patient Predictors of Readmission for Heart Failure: A Systematic Review
Ross JS, Mulvey GK, Stauffer B, Patlolla V, Bernheim SM, Keenan PS, Krumholz HM. Statistical Models and Patient Predictors of Readmission for Heart Failure: A Systematic Review. JAMA Internal Medicine 2008, 168: 1371-1386. PMID: 18625917, DOI: 10.1001/archinte.168.13.1371.Peer-Reviewed Original ResearchMeSH KeywordsDisease ProgressionEvidence-Based MedicineFemaleHeart FailureHospitalizationHumansIncidenceMaleModels, StatisticalPatient ReadmissionPredictive Value of TestsProportional Hazards ModelsQuality-Adjusted Life YearsRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSurvival AnalysisUnited StatesConceptsPatient characteristicsPatient readmission riskReadmission riskPatient riskSystematic reviewReadmission ratesHospital ratesOvid Evidence-Based Medicine ReviewsEligible English-language publicationsEvidence-Based Medicine ReviewsHeart failure hospitalizationPatient risk stratificationEnglish-language literatureEnglish-language publicationsFailure hospitalizationHF hospitalizationAdult patientsHeart failureHospital readmissionMedicine ReviewsRisk stratificationPatient predictorsInclusion criteriaReadmissionCombined outcomeDual Use of Veterans Affairs Services and Use of Recommended Ambulatory Care
Ross JS, Keyhani S, Keenan PS, Bernheim SM, Penrod JD, Boockvar KS, Krumholz HM, Siu AL. Dual Use of Veterans Affairs Services and Use of Recommended Ambulatory Care. Medical Care 2008, 46: 309-316. PMID: 18388846, DOI: 10.1097/mlr.0b013e31815b9db3.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAmbulatory CareBehavioral Risk Factor Surveillance SystemCross-Sectional StudiesFemaleHealth Services AccessibilityHumansMaleMiddle AgedPrimary Health CareQuality Indicators, Health CareQuality of Health CareSocioeconomic FactorsUnited StatesUnited States Department of Veterans AffairsConceptsVA usersPatient characteristicsCancer screeningDual usersVeterans Affairs Medical SystemBehavior Risk Factor Surveillance SystemRisk Factor Surveillance SystemCardiovascular risk reductionMultivariable logistic regressionProstate cancer screeningAmbulatory care servicesVeterans Affairs servicesCommunity-dwelling adultsBreast cancer screeningLow useCross-sectional analysisInfectious disease preventionHealth care systemInfluenza vaccinationCare patientsSelf-reported useUnadjusted analysesCancer preventionOutcome measuresAmbulatory care