Featured Publications
Differential abundance analysis for microbial marker-gene surveys
Paulson J, Stine O, Bravo H, Pop M. Differential abundance analysis for microbial marker-gene surveys. Nature Methods 2013, 10: 1200-1202. PMID: 24076764, PMCID: PMC4010126, DOI: 10.1038/nmeth.2658.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsArea Under CurveCluster AnalysisComputer SimulationDatabases, GeneticGene Expression ProfilingGenetic MarkersGenetic VariationHumansIntestinesMetagenomicsMiceMicrobiotaModels, GeneticModels, StatisticalNormal DistributionPhenotypeRNA, Ribosomal, 16SSequence Analysis, DNASoftware
2014
Diarrhea in young children from low-income countries leads to large-scale alterations in intestinal microbiota composition
Pop M, Walker A, Paulson J, Lindsay B, Antonio M, Hossain M, Oundo J, Tamboura B, Mai V, Astrovskaya I, Bravo H, Rance R, Stares M, Levine M, Panchalingam S, Kotloff K, Ikumapayi U, Ebruke C, Adeyemi M, Ahmed D, Ahmed F, Alam M, Amin R, Siddiqui S, Ochieng J, Ouma E, Juma J, Mailu E, Omore R, Morris J, Breiman R, Saha D, Parkhill J, Nataro J, Stine O. Diarrhea in young children from low-income countries leads to large-scale alterations in intestinal microbiota composition. Genome Biology 2014, 15: r76. PMID: 24995464, PMCID: PMC4072981, DOI: 10.1186/gb-2014-15-6-r76.Peer-Reviewed Original ResearchConceptsMicrobiota compositionAnaerobic lineagesRRNA gene sequencesGut microbiota compositionLevels of PrevotellaDiarrhea-causing pathogensSevere diarrheal diseaseIntestinal microbiota compositionFecal microbiota compositionGene sequencesDiarrheal pathogensDiarrhea pathogensMolecular techniquesPathogensDiarrhea-free controlsGranulicatella speciesEscherichia/ShigellaDiarrheal diseaseLineagesMSD casesYears of ageBackgroundDiarrheal diseasesYoung childrenAssociated with MSDLow-income countries