2022
Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of Paenibacillus thiaminolyticus
Hehnly C, Shi A, Ssentongo P, Zhang L, Isaacs A, Morton S, Streck N, Erdmann-Gilmore P, Tolstoy I, Townsend R, Limbrick D, Paulson J, Ericson J, Galperin M, Schiff S, Broach J. Type IV Pili Are a Critical Virulence Factor in Clinical Isolates of Paenibacillus thiaminolyticus. MBio 2022, 13: e02688-22. PMID: 36374038, PMCID: PMC9765702, DOI: 10.1128/mbio.02688-22.Peer-Reviewed Original ResearchConceptsPostinfectious hydrocephalusClinical isolatesVirulence factorsCritical virulence factorPotential virulence factorsPoor long-term outcomesPrevention of hydrocephalusLong-term outcomesBacterial pathogensDevastating sequelaeNeonatal sepsisMiddle-income countriesNeonatal infectionSurgical interventionReference strainsNovel bacterial pathogensAfrican cohortBeta-lactamase genesChildhood mortalityHydrocephalusTherapeutic targetInfectionVirulent strainDevastating diseaseWhole-genome sequencing
2018
An Introduced Crop Plant Is Driving Diversification of the Virulent Bacterial Pathogen Erwinia tracheiphila
Shapiro L, Paulson J, Arnold B, Scully E, Zhaxybayeva O, Pierce N, Rocha J, Klepac-Ceraj V, Holton K, Kolter R. An Introduced Crop Plant Is Driving Diversification of the Virulent Bacterial Pathogen Erwinia tracheiphila. MBio 2018, 9: 10.1128/mbio.01307-18. PMID: 30279283, PMCID: PMC6168856, DOI: 10.1128/mbio.01307-18.Peer-Reviewed Original ResearchConceptsTemperate eastern North AmericaEastern North AmericaErwinia tracheiphila</i>,Host plant speciesPlant speciesCrop plantsCausal agent of bacterial wiltAgent of bacterial wiltVirulence gene repertoireLow genetic heterogeneityLarge-scale sequencingSusceptible to isolatesNorth AmericaDriving diversificationPhylogenomic analysisPopulation bottlenecksGenetic clustersEcological traitsIsolate collectionGene repertoirePopulation expansionGeographic rangeEvolutionary trajectoriesGenetic heterogeneityCausal agent