Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface
Carette X, Platig J, Young D, Helmel M, Young A, Wang Z, Potluri L, Moody C, Zeng J, Prisic S, Paulson J, Muntel J, Madduri A, Velarde J, Mayfield J, Locher C, Wang T, Quackenbush J, Rhee K, Moody D, Steen H, Husson R. Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface. MBio 2018, 9: 10.1128/mbio.02333-17. PMID: 29511081, PMCID: PMC5845002, DOI: 10.1128/mbio.02333-17.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateBacterial ProteinsGene Expression Regulation, BacterialMycobacterium tuberculosisPhosphorylationProtein Serine-Threonine KinasesSignal TransductionConceptsMycobacterial cell envelopeCell envelopePeptidoglycan turnoverProtein abundanceResponse regulator MtrAProtein secretion systemStress responseEnvelope stress responsePhosphorylated cellular proteinsRegulate essential processesDifferentially phosphorylated proteinsSerine/threonine protein kinaseTransport of proteinsLevel of gene expressionAnalysis of phosphoproteinsEssential cell functionsLevel of phosphorylationDNA binding activityDecreased expression of genesCell wall lipidsExpression of genesLipid contentIncreasing multidrug resistanceSecretion systemVirulence determinants