2020
Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues
Lopes-Ramos C, Chen C, Kuijjer M, Paulson J, Sonawane A, Fagny M, Platig J, Glass K, Quackenbush J, DeMeo D. Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues. Cell Reports 2020, 31: 107795. PMID: 32579922, PMCID: PMC7898458, DOI: 10.1016/j.celrep.2020.107795.Peer-Reviewed Original ResearchConceptsGene regulatory networksTranscription factorsGenotype-Tissue ExpressionRegulatory networksArchitecture of gene regulatory networksRepertoire of transcription factorsSets of transcription factorsRegulatory network structureWhole-genome expression profilingTissue-related functionsGenes associated with Parkinson's diseaseHuman healthy tissuesGene regulationGene expressionMolecular basisSystems-based analysisExpression profilesGenesAlzheimer's diseaseRegulatory processesHuman tissuesExpressionTranscriptionTissueSex differences
2017
Understanding Tissue-Specific Gene Regulation
Sonawane A, Platig J, Fagny M, Chen C, Paulson J, Lopes-Ramos C, DeMeo D, Quackenbush J, Glass K, Kuijjer M. Understanding Tissue-Specific Gene Regulation. Cell Reports 2017, 21: 1077-1088. PMID: 29069589, PMCID: PMC5828531, DOI: 10.1016/j.celrep.2017.10.001.Peer-Reviewed Original ResearchMeSH KeywordsGene Regulatory NetworksGenome, HumanHumansOrgan SpecificityProtein Interaction MapsTranscription FactorsTranscriptional ActivationTranscriptomeConceptsTissue specificityTissue-specific gene regulationGenotype-Tissue Expression projectControl tissue specificityTissue-specific genesTranscription factor targetsTissue-specific functionsGene expression patternsGene set enrichment analysisTissue-specific mannerTissue-specific processesInvestigate gene expressionGene regulationRegulatory interactionsTranscriptional controlTranscription factor expressionTranscription factorsExpression projectEnrichment analysisGene expressionExpression patternsGenesRegulation nodeFactor targetsTranscription