S845 PREDICTED NEOANTIGENS PROVIDE PROGNOSTIC INSIGHT IN DLBCL
Paulson J, Jin D, Sokol E, Nielsen T, Venstrom J, Trabucco S. S845 PREDICTED NEOANTIGENS PROVIDE PROGNOSTIC INSIGHT IN DLBCL. HemaSphere 2019, 3: 377. DOI: 10.1097/01.hs9.0000561660.80605.a5.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaTumor mutational burdenComprehensive genomic profilingNeoantigen burdenImmune surveillanceClinical outcomesPrognostic insightsPoor outcomeEstimate tumor mutation burdenMedian tumor mutation burdenPersonalized cancer vaccine strategiesHigh tumor mutational burdenLarge B-cell lymphomaEvasion of immune surveillanceVaccination strategiesCancer vaccine strategiesAssociated with worsened outcomesB-cell lymphomaMultivariate Cox regressionImpact clinical outcomesCell of originMHC-I presentationBCL2 alterationsDLBCL cohortPrognostic factors