2020
Abstract PR06: The immunogenomic landscape of pediatric primary solid tumors
Nabbi A, Sun P, Sumedha S, Zhu K, Yang S, Paulson J, Kool M, Rathi K, Kalletla K, Raman P, Zhu Y, Resnick A, Jones D, Jäger N, Pfister S, Pugh T. Abstract PR06: The immunogenomic landscape of pediatric primary solid tumors. Cancer Research 2020, 80: pr06-pr06. DOI: 10.1158/1538-7445.pedca19-pr06.Peer-Reviewed Original ResearchTumor mutational burdenAtypical teratoid/rhabdoid tumorPrimary solid tumorsPediatric CNS tumorsSolid tumorsCNS tumorsPediatric cancerImmune microenvironmentPediatric tumorsT cellsImmunogenomic landscapeImmune cellsLevels of CD8+ T cellsHigh T-cell infiltrationCD8+ T cellsClonal T-cell expansionAssociated with immune cell infiltrationT cell clonal expansionAnalysis of T cell repertoireLow levels of immune infiltrationImmune checkpoint inhibitionEffect of immunotherapyT cell infiltrationLevel of immune infiltrationT cell expansion
2019
Abstract 2891: Landscape of infiltrating immune repertoire in pediatric solid tumors
Nabbi A, Jäger N, Sudhaman S, Sun P, Yang S, Zhu K, Kool M, Rathi K, Kalletla K, Raman P, Zhu Y, Paulson J, Jones D, Tabori U, Resnick A, Pfister S, Pugh T. Abstract 2891: Landscape of infiltrating immune repertoire in pediatric solid tumors. Cancer Research 2019, 79: 2891-2891. DOI: 10.1158/1538-7445.am2019-2891.Peer-Reviewed Original ResearchPediatric solid tumorsTumor microenvironmentSolid tumorsConstitutional mismatch repair deficiencyImmune repertoirePediatric cancerExpression profiles of immune cellsCompared to adult counterpartsAssociated with clinical responseImmune checkpoint gene expressionProfile of immune cellsImmune checkpoint blockadeAntigen presentation machineryCheckpoint gene expressionDeterminants of immune responseT cell receptorChildren's Brain Tumor Tissue ConsortiumInternational Cancer Genome ConsortiumCheckpoint blockadeImmunosuppressive environmentPresentation machineryRare malignancyCancer Genome ConsortiumClinical responseMismatch repair deficiency