Minimal genetic change in Vibrio cholerae in Mozambique over time: Multilocus variable number tandem repeat analysis and whole genome sequencing
Garrine M, Mandomando I, Vubil D, Nhampossa T, Acacio S, Li S, Paulson J, Almeida M, Domman D, Thomson N, Alonso P, Stine O. Minimal genetic change in Vibrio cholerae in Mozambique over time: Multilocus variable number tandem repeat analysis and whole genome sequencing. PLOS Neglected Tropical Diseases 2017, 11: e0005671. PMID: 28622368, PMCID: PMC5489214, DOI: 10.1371/journal.pntd.0005671.Peer-Reviewed Original ResearchConceptsMultilocus variable-number tandem-repeat analysisWhole-genome sequencingTandem repeat analysisGenome sequenceMultilocus variable number tandem repeat analysisVariable number tandem repeat analysisVariable-number tandem repeat analysisCholera toxin geneVibrio cholerae isolatesPresence of recombinationMinimal genetic changeMLVA lociCholerae isolatesSeventh pandemicGenetic relatednessClonal complexesToxin genesMolecular clockVibrio choleraeClinical isolatesIdentical isolatesGenetic changesRepeat analysisEnvironmental reservoirsIsolates