Abstract PR06: The immunogenomic landscape of pediatric primary solid tumors
Nabbi A, Sun P, Sumedha S, Zhu K, Yang S, Paulson J, Kool M, Rathi K, Kalletla K, Raman P, Zhu Y, Resnick A, Jones D, Jäger N, Pfister S, Pugh T. Abstract PR06: The immunogenomic landscape of pediatric primary solid tumors. Cancer Research 2020, 80: pr06-pr06. DOI: 10.1158/1538-7445.pedca19-pr06.Peer-Reviewed Original ResearchTumor mutational burdenAtypical teratoid/rhabdoid tumorPrimary solid tumorsPediatric CNS tumorsSolid tumorsCNS tumorsPediatric cancerImmune microenvironmentPediatric tumorsT cellsImmunogenomic landscapeImmune cellsLevels of CD8+ T cellsHigh T-cell infiltrationCD8+ T cellsClonal T-cell expansionAssociated with immune cell infiltrationT cell clonal expansionAnalysis of T cell repertoireLow levels of immune infiltrationImmune checkpoint inhibitionEffect of immunotherapyT cell infiltrationLevel of immune infiltrationT cell expansion