Abstract 2891: Landscape of infiltrating immune repertoire in pediatric solid tumors
Nabbi A, Jäger N, Sudhaman S, Sun P, Yang S, Zhu K, Kool M, Rathi K, Kalletla K, Raman P, Zhu Y, Paulson J, Jones D, Tabori U, Resnick A, Pfister S, Pugh T. Abstract 2891: Landscape of infiltrating immune repertoire in pediatric solid tumors. Cancer Research 2019, 79: 2891-2891. DOI: 10.1158/1538-7445.am2019-2891.Peer-Reviewed Original ResearchPediatric solid tumorsTumor microenvironmentSolid tumorsConstitutional mismatch repair deficiencyImmune repertoirePediatric cancerExpression profiles of immune cellsCompared to adult counterpartsAssociated with clinical responseImmune checkpoint gene expressionProfile of immune cellsImmune checkpoint blockadeAntigen presentation machineryCheckpoint gene expressionDeterminants of immune responseT cell receptorChildren's Brain Tumor Tissue ConsortiumInternational Cancer Genome ConsortiumCheckpoint blockadeImmunosuppressive environmentPresentation machineryRare malignancyCancer Genome ConsortiumClinical responseMismatch repair deficiency