2015
CD44 Influences Fibroblast Behaviors Via Modulation of Cell–Cell and Cell–Matrix Interactions, Affecting Survivin and Hippo Pathways
Tsuneki M, Madri JA. CD44 Influences Fibroblast Behaviors Via Modulation of Cell–Cell and Cell–Matrix Interactions, Affecting Survivin and Hippo Pathways. Journal Of Cellular Physiology 2015, 231: 731-743. PMID: 26248063, DOI: 10.1002/jcp.25123.Peer-Reviewed Original ResearchConceptsHippo pathwayN-cadherinCaspase-3Cell-matrix interactionsSiRNA knock-downCollagen type IPivotal roleNon-coated dishesKnock-downExtracellular matrix expressionHigh cell densitySiRNA knockdownCell adhesionCell behaviorCell typesDiverse arrayPhospho-YAPNuclear fractionRole of CD44Fibroblast migrationFibroblast behaviorType IMesenchymal tissuePathwayCells cells
1998
Immunofluorescence Characterization of Key Extracellular Matrix Proteins in Murine Bone Marrow In Situ
Nilsson S, Debatis M, Dooner M, Madri J, Quesenberry P, Becker P. Immunofluorescence Characterization of Key Extracellular Matrix Proteins in Murine Bone Marrow In Situ. Journal Of Histochemistry & Cytochemistry 1998, 46: 371-377. PMID: 9487119, DOI: 10.1177/002215549804600311.Peer-Reviewed Original ResearchConceptsExtracellular matrix proteinsMatrix proteinsKey extracellular matrix proteinsParticular extracellular matrix proteinsExtracellular matrix protein fibronectinStem cellsCentral marrow regionsMatrix protein fibronectinStem cell proliferationCollagen type IMurine bone marrowHemopoietic stem cellsProtein fibronectinBone marrow vesselsExtracellular matrixBone marrowMechanistic roleCell proliferationProteinMarrow microenvironmentImportant mechanistic roleMolecular interactionsImmunofluorescence labelingCollagen type IVType I
1995
Human capillary endothelial cells from abdominal wall adipose tissue: Isolation using an anti-pecam antibody
Springhorn J, Madri J, Squinto S. Human capillary endothelial cells from abdominal wall adipose tissue: Isolation using an anti-pecam antibody. In Vitro Cellular & Developmental Biology - Animal 1995, 31: 473-481. PMID: 8589892, DOI: 10.1007/bf02634261.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAdipose TissueAnimalsAntibodies, MonoclonalAntigens, Differentiation, MyelomonocyticCell Adhesion MoleculesCell SeparationCell Transformation, ViralCells, CulturedEndothelium, VascularGrowth HormoneHumansLectinsPlant LectinsPlatelet Endothelial Cell Adhesion Molecule-1Vascular Cell Adhesion Molecule-1Von Willebrand FactorConceptsCapillary endothelial cellsHuman capillary endothelial cellsAnti-PECAM antibodyEndothelial cellsCellular adhesion moleculesVon Willebrand factorAdipose tissueDensity lipoproteinAdhesion molecule antibodyGrowth hormoneFlow cytometryMolecule antibodiesAdhesion moleculesAntibodiesWillebrand factorPassage sixNormal patternAntibody methodCell isolatesImmunofluorescent labelingAgglutinin lectinType IExpression of Transforming Growth Factor Type III Receptor in Vascular Endothelial Cells Increases Their Responsiveness to Transforming Growth Factor β2 ∗
Sankar S, Mahooti-Brooks N, Centrella M, McCarthy T, Madri J. Expression of Transforming Growth Factor Type III Receptor in Vascular Endothelial Cells Increases Their Responsiveness to Transforming Growth Factor β2 ∗. Journal Of Biological Chemistry 1995, 270: 13567-13572. PMID: 7768960, DOI: 10.1074/jbc.270.22.13567.Peer-Reviewed Original ResearchConceptsTGF beta 2Type II receptorBovine aortic endothelial cellsTGF beta 1Receptor proteinType III receptorII receptorsBeta 2TGF-beta type III receptorBeta 1Serine-threonine kinaseInhibitor-1 proteinPlasminogen activator inhibitor-1 proteinEndothelial cellsTGF beta sGrowth factor betaGrowth factor β2Inhibition of migrationVascular endothelial cellsSignaling capacityType IAortic endothelial cellsReceptor cDNAReceptor complexProtein
1992
Modulation of vascular cell behavior by transforming growth factors β
Madri J, Bell L, Merwin J. Modulation of vascular cell behavior by transforming growth factors β. Molecular Reproduction And Development 1992, 32: 121-126. PMID: 1637550, DOI: 10.1002/mrd.1080320207.Peer-Reviewed Original ResearchConceptsVascular cell typesCell typesCellular responsesCell surfaceTGF-beta receptorsVascular cell behaviorGrowth factor βDistinct bioassaysDifferent isoformsCell migrationCell behaviorInhibition of proliferationVascular cell responsesSmooth muscle cellsUnique binding profileAngiogenic assaysIsoformsBinding profileCell populationsBovine aortic endothelialFactor βMuscle cellsType IBASMCsAortic endothelial
1991
Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.
Merwin J, Newman W, Beall L, Tucker A, Madri J. Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro. American Journal Of Pathology 1991, 138: 37-51. PMID: 1846264, PMCID: PMC1886039.Peer-Reviewed Original ResearchConceptsBovine aortic endothelial cellsBovine aortic smooth muscle cellsGrowth factorGrowth factor beta 1Aortic smooth muscle cellsTGF-beta concentrationsSmooth muscle cellsProliferation of BAECsTGF-beta receptorsBovine aortic endothelial cell migrationType IAortic endothelial cellsTGF beta sCell typesMicrovascular endotheliumVascular cell typesReceptor assayMuscle cellsVascular cellsEndothelial cellsBeta 1Endothelial cell migrationBeta 2Angiogenic assaysBASMCs
1987
An immunohistochemical and serum ELISA study of type I and III procollagen aminopropeptides in primary biliary cirrhosis.
Davis B, Madri J. An immunohistochemical and serum ELISA study of type I and III procollagen aminopropeptides in primary biliary cirrhosis. American Journal Of Pathology 1987, 128: 265-75. PMID: 3303951, PMCID: PMC1899633.Peer-Reviewed Original ResearchConceptsType III procollagenPrimary biliary cirrhosisDegree of fibrosisSerum levelsBiliary cirrhosisType ICorresponding liver biopsiesGroup of patientsLevel of inflammationLiver biopsyNormal limitsInflammationELISA studiesCirrhosisAminopropeptideFibrosisELISA methodologyProcollagenMature type IBiopsyPatientsLevelsImmunohistochemistryImmunoperoxidaseLiverType I and type III procollagen peptides during hepatic fibrogenesis. An immunohistochemical and ELISA serum study in the CCl4 rat model.
Davis B, Madri J. Type I and type III procollagen peptides during hepatic fibrogenesis. An immunohistochemical and ELISA serum study in the CCl4 rat model. American Journal Of Pathology 1987, 126: 137-47. PMID: 2433943, PMCID: PMC1899545.Peer-Reviewed Original ResearchConceptsDays of treatmentSGPT valuesHepatic fibrogenesisSerum assaysProcollagen peptideType IHepatic collagen depositionUseful clinical indicatorCCl4 rat modelCarbon tetrachloride modelExtracellular collagen degradationHistologic inflammationSGPT levelsClinical indicatorsHepatic fibrosisHistologic fibrosisRat modelRoutine histologicSerum studiesClinical utilityCollagen depositionLinear regression analysisNormal levelsELISA assaysImmunofluorescent staining
1986
Collagen types I, III, and V in human embryonic and fetal skin
Smith L, Holbrook K, Madri J. Collagen types I, III, and V in human embryonic and fetal skin. Developmental Dynamics 1986, 175: 507-521. PMID: 3521252, DOI: 10.1002/aja.1001750409.Peer-Reviewed Original ResearchConceptsDermal-epidermal junctionReticular regionsType IIIFetal skinType IType VCollagen type IWeeks of gestationSubdermal connective tissueAdult-like patternLarge diameter fibrilsGestational ageFirst trimesterImmunoperoxidase dataPapillary regionImmunoperoxidase stainingType III collagenFetal ageFibrillar collagenLight microscope levelBlood vesselsConnective tissueDermal collagen fibrilsCollagen fibrilsType V collagen
1985
Immunolocalization of type IV collagen and laminin in nonbasement membrane structures of murine corneal stroma. A light and electron microscopic study.
Pratt B, Madri J. Immunolocalization of type IV collagen and laminin in nonbasement membrane structures of murine corneal stroma. A light and electron microscopic study. Laboratory Investigation 1985, 52: 650-6. PMID: 3892156.Peer-Reviewed Original ResearchConceptsElectron microscopic immunolocalizationMicrofibril bundlesInterstitial collagen types IType IV collagenPossible functionsExtracellular matrixImmunofluorescent localizationMembrane structureIV collagenCollagen type IType IType V collagenOxytalan microfibrilsImmunolocalizationCellular sourceMicrofibrilsLaminin
1984
Scar cancers of the lung: Origin and significance
Madri J, Carter D. Scar cancers of the lung: Origin and significance. Human Pathology 1984, 15: 625-631. PMID: 6378757, DOI: 10.1016/s0046-8177(84)80286-5.Peer-Reviewed Original ResearchConceptsPulmonary neoplasiaFibrotic processHost responseNontumorous areasScar cancerPulmonary tumorsColonic neoplasmsLung parenchymaFibrotic responseType III collagenCollagen antibodiesNeoplasmsCurrent conceptsType IIIDesmoplasiaLungNeoplasiaScarringTumorsScarCancerType ICollagen typesDifferent collagen typesCollagen
1981
The immune response to human type III and type V (AB2) collagen: antigenic determinants and genetic control in mice
Kemp J, Madri J. The immune response to human type III and type V (AB2) collagen: antigenic determinants and genetic control in mice. European Journal Of Immunology 1981, 11: 90-94. PMID: 6163643, DOI: 10.1002/eji.1830110205.Peer-Reviewed Original ResearchConceptsAntibody responseSpecific IgG antibody responseAntigenic determinantsIgG antibody responseHigher antibody responseT cell recognitionType IIIType IHuman type IIIHigh-affinity monoclonal antibodiesAntigen presentationImmune responseBovine collagen type IMonoclonal antibodiesCollagen type IIr genesType V collagenCell recognitionHuman collagenFurther studiesConnective tissue biologyTissue biologyMicePresent studyCollagen
1980
Collagen polymorphism in the lung An immunochemical study of pulmonary fibrosis
Madri J, Furthmayr H. Collagen polymorphism in the lung An immunochemical study of pulmonary fibrosis. Human Pathology 1980, 11: 353-366. PMID: 6997183, DOI: 10.1016/s0046-8177(80)80031-1.Peer-Reviewed Original ResearchConceptsPerivascular localizationLung samplesFibrotic human lungSmooth muscle cell proliferationType IIndirect immunofluorescence techniqueLung type IMuscle cell proliferationType VType IIICapillary basement membranePulmonary fibrosisFibrotic processAlveolar septaType IV collagenImmunofluorescence techniqueHuman lungCell proliferationInterstitiumMarked increaseType IVBasement membraneImmunochemical studiesIrregular localizationIV collagen