2020
Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit
Edlow B, Barra M, Zhou D, Foulkes A, Snider S, Threlkeld Z, Chakravarty S, Kirsch J, Chan S, Meisler S, Bleck T, Fins J, Giacino J, Hochberg L, Solt K, Brown E, Bodien Y. Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit. Neurocritical Care 2020, 33: 364-375. PMID: 32794142, PMCID: PMC8336723, DOI: 10.1007/s12028-020-01062-7.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain Injuries, TraumaticConnectomeConsciousnessHumansIntensive Care UnitsTreatment OutcomeConceptsIntensive care unitPromote recovery of consciousnessRecovery of consciousnessIntravenous methylphenidateEarly recovery of consciousnessPromote early recoveryPhase 2aDrug-related adverse eventsCare unitAscending arousal networkEscalating daily dosesHighest tolerated doseAcute severe traumatic brain injuryDose-finding studyOutcome measuresBrain injurySerum half-lifeMaximal serum concentrationPrimary outcome measureWithdrawal of life-sustaining therapyDrug’s pharmacodynamic propertiesSecondary outcome measuresMagnetic resonance imagingOpen-labelPharmacodynamic criteria
2018
Assessment of Covert Consciousness in the Intensive Care Unit
Edlow B, Fins J. Assessment of Covert Consciousness in the Intensive Care Unit. Journal Of Head Trauma Rehabilitation 2018, 33: 424-434. PMID: 30395042, PMCID: PMC6317885, DOI: 10.1097/htr.0000000000000448.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTraumatic brain injuryAcute severe traumatic brain injurySevere traumatic brain injuryIntensive care unitCovert consciousnessEthical challengesIntensive care unit patientsTask-based functional magnetic resonance imagingTask-based fMRILife-sustaining therapyWithdrawal of life-sustaining therapyCare unitEthical frameworkBehavioral assessmentCritically ill patientsEvaluation normsMagnetic resonance imagingConsciousnessBrain injuryGoals of careClinical scenariosIll patientsRecovered consciousnessTreatment decisions
2013
Surrogate expectations in severe brain injury
Suppes A, Fins J. Surrogate expectations in severe brain injury. Brain Injury 2013, 27: 1141-1147. PMID: 23895513, PMCID: PMC5454804, DOI: 10.3109/02699052.2013.804201.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdvance Care PlanningAdvance DirectivesBrain InjuriesCaregiversChildComaDecision MakingFamilyFemaleGriefHumansIntensive Care UnitsMaleMiddle AgedNew YorkPersistent Vegetative StatePhysician's RoleProfessional-Family RelationsPrognosisProxySeverity of Illness IndexStress, PsychologicalConceptsSource of injuryExpectations of recoveryPsychosocial featuresDecision-making expectationsQuantitative questionnaireImprove treatment of patientsFamily membersPatient recoveryTreatment of patientsPatient diagnosisRelated factorsDOC patientsBrain injuryPatientsImproved treatmentInjuryCurrent diagnosisExpectationsQuestionnaireDiagnosisCliniciansBrainSurveyFactors
2008
Prospective Analysis of Life-Sustaining Therapy Discussions in the Surgical Intensive Care Unit: A Housestaff Perspective
Pieracci F, Ullery B, Eachempati S, Nilson E, Hydo L, Barie P, Fins J. Prospective Analysis of Life-Sustaining Therapy Discussions in the Surgical Intensive Care Unit: A Housestaff Perspective. Journal Of The American College Of Surgeons 2008, 207: 468-476. PMID: 18926447, DOI: 10.1016/j.jamcollsurg.2008.05.001.Peer-Reviewed Original ResearchConceptsEnd-of-life care planningEnd-of-lifeLack of decision-making capacityCare planningDecision-making capacityEnd-of-life careLikelihood of enactmentSurgical ICUPatient surrogatesHousestaffStandardized questionnaireSurgical intensive care unitClinical deteriorationIntensive care unitProspective dataCare unitProspective analysisPatientsICUAgeCareAcuityDisparitiesQuestionnairePlanning
2006
Factors Influencing DNR Decision-Making in a Surgical ICU
Bacchetta M, Eachempati S, Fins J, Hydo L, Barie P. Factors Influencing DNR Decision-Making in a Surgical ICU. Journal Of The American College Of Surgeons 2006, 202: 995-1000. PMID: 16735215, DOI: 10.1016/j.jamcollsurg.2006.02.027.Peer-Reviewed Original ResearchMeSH KeywordsAgedCritical IllnessDecision MakingGeneral SurgeryHumansIntensive Care UnitsPrognosisResuscitation OrdersRetrospective StudiesSeverity of Illness IndexConceptsDNR ordersPresence of DNR ordersCritically ill surgical patientsEnd-of-life decisionsDNR decision-makingNo-DNR groupIll surgical patientsMedical historyMultiple organ dysfunction scoreEnd-of-lifeOrgan dysfunction scoreIII scoreAcuity of illnessSurgical patientsChi-square statistical testMultivariate ANOVADNR patientsHospital length of stayDysfunction scoreIll patient populationLength of stayCritically ill patient populationAPACHE III scoreDNRIllness severity
1999
Incorporating palliative care into critical care education: Principles, challenges, and opportunities
Danis M, Federman D, Fins J, Fox E, Kastenbaum B, Lanken P, Long K, Lowenstein E, Lynn J, Rouse F, Tulsky J. Incorporating palliative care into critical care education: Principles, challenges, and opportunities. Critical Care Medicine 1999, 27: 2005-2013. PMID: 10507632, DOI: 10.1097/00003246-199909000-00047.Peer-Reviewed Original ResearchConceptsEnd-of-life carePalliative careEnd-of-lifeIntensive care unitCare educationModified nominal group processCritical careExcellent palliative carePalliative care educationCompassionate palliative careDiscontinuity of careGoals of careCritical care educationNominal group processTrust relationshipsCapacity of patientsDying patientsGood careTeaching careConsumer advocacyMedical educationCareEffective communicationLife support technologyCare unit
1994
Encountering diversity: Medical ethics and pluralism
Fins J. Encountering diversity: Medical ethics and pluralism. Journal Of Religion And Health 1994, 33: 23-27. PMID: 11659797, DOI: 10.1007/bf02354496.Peer-Reviewed Original ResearchMeSH KeywordsAgedBioethical IssuesBioethicsCultural DiversityDecision MakingEthicsEthics, MedicalEuthanasia, PassiveFamilyFreedomHome Care ServicesHumansIntensive Care UnitsJewsJudaismLife Support CareNarrationPersonal AutonomyPhilosophyPhysician-Patient RelationsReligionSecularismSocial ValuesTerminally IllThird-Party ConsentUnited StatesVentilators, MechanicalWithholding Treatment