2020
Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?
Wu H, Hariz M, Visser-Vandewalle V, Zrinzo L, Coenen V, Sheth S, Bervoets C, Naesström M, Blomstedt P, Coyne T, Hamani C, Slavin K, Krauss J, Kahl K, Taira T, Zhang C, Sun B, Toda H, Schlaepfer T, Chang J, Régis J, Schuurman R, Schulder M, Doshi P, Mosley P, Poologaindran A, Lázaro-Muñoz G, Pepper J, Schechtmann G, Fytagoridis A, Huys D, Gonçalves-Ferreira A, D’Haese P, Neimat J, Broggi G, Vilela-Filho O, Voges J, Alkhani A, Nakajima T, Richieri R, Djurfeldt D, Fontaine P, Martinez-Alvarez R, Okamura Y, Chandler J, Watanabe K, Barcia J, Reneses B, Lozano A, Gabriëls L, De Salles A, Halpern C, Matthews K, Fins J, Nuttin B. Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy? Molecular Psychiatry 2020, 26: 60-65. PMID: 33144712, PMCID: PMC7815503, DOI: 10.1038/s41380-020-00933-x.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTreatment-refractory obsessive-compulsive disorderRefractory obsessive-compulsive disorderDeep brain stimulationTreatment of psychiatric patientsBrain stimulationProspective international multi-center studyY-BOCSClinical trialsAcceptable risk-benefit ratioPsychiatric patientsBrain areasPsychiatric indicationsRandomized controlled clinical trialLevel I evidenceRisk-benefit ratioClinical cohort studyMulti-center studyInternational multi-center studyLevel II evidenceRandomized controlled trialsSurgical treatmentPsychiatristsConsensus guidelinesCohort studyPersonalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit
Edlow B, Barra M, Zhou D, Foulkes A, Snider S, Threlkeld Z, Chakravarty S, Kirsch J, Chan S, Meisler S, Bleck T, Fins J, Giacino J, Hochberg L, Solt K, Brown E, Bodien Y. Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit. Neurocritical Care 2020, 33: 364-375. PMID: 32794142, PMCID: PMC8336723, DOI: 10.1007/s12028-020-01062-7.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain Injuries, TraumaticConnectomeConsciousnessHumansIntensive Care UnitsTreatment OutcomeConceptsIntensive care unitPromote recovery of consciousnessRecovery of consciousnessIntravenous methylphenidateEarly recovery of consciousnessPromote early recoveryPhase 2aDrug-related adverse eventsCare unitAscending arousal networkEscalating daily dosesHighest tolerated doseAcute severe traumatic brain injuryDose-finding studyOutcome measuresBrain injurySerum half-lifeMaximal serum concentrationPrimary outcome measureWithdrawal of life-sustaining therapyDrug’s pharmacodynamic propertiesSecondary outcome measuresMagnetic resonance imagingOpen-labelPharmacodynamic criteria
2016
What's Wrong with Evidence‐Based Medicine?
Fins J. What's Wrong with Evidence‐Based Medicine? The Hastings Center Report 2016, 46: inside back cover-inside back cover. PMID: 26786040, DOI: 10.1002/hast.534.Peer-Reviewed Original Research
2012
Severe Brain Injury and Organ Solicitation: A Call for Temperance
Fins J. Severe Brain Injury and Organ Solicitation: A Call for Temperance. The AMA Journal Of Ethic 2012, 14: 221. PMID: 23352008, DOI: 10.1001/virtualmentor.2012.14.3.stas1-1203.Peer-Reviewed Original Research
2010
Deep Brain Stimulation and the Neuroethics of Responsible Publishing: When One Is Not Enough
Schlaepfer T, Fins J. Deep Brain Stimulation and the Neuroethics of Responsible Publishing: When One Is Not Enough. JAMA 2010, 303: 775-776. PMID: 20179289, DOI: 10.1001/jama.2010.140.Peer-Reviewed Original Research
2009
Deep Brain Stimulation, Neuroethics, and the Minimally Conscious State: Moving Beyond Proof of Principle
Schiff N, Giacino J, Fins J. Deep Brain Stimulation, Neuroethics, and the Minimally Conscious State: Moving Beyond Proof of Principle. JAMA Neurology 2009, 66: 697-702. PMID: 19506129, DOI: 10.1001/archneurol.2009.79.Peer-Reviewed Original Research
2007
Behavioural improvements with thalamic stimulation after severe traumatic brain injury
Schiff N, Giacino J, Kalmar K, Victor J, Baker K, Gerber M, Fritz B, Eisenberg B, O’Connor J, Kobylarz E, Farris S, Machado A, McCagg C, Plum F, Fins J, Rezai A. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 2007, 448: 600-603. PMID: 17671503, DOI: 10.1038/nature06041.Peer-Reviewed Original Research