2023
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Schiff N, Giacino J, Butson C, Choi E, Baker J, O’Sullivan K, Janson A, Bergin M, Bronte-Stewart H, Chua J, DeGeorge L, Dikmen S, Fogarty A, Gerber L, Krel M, Maldonado J, Radovan M, Shah S, Su J, Temkin N, Tourdias T, Victor J, Waters A, Kolakowsky-Hayner S, Fins J, Machado A, Rutt B, Henderson J. Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study. Nature Medicine 2023, 29: 3162-3174. PMID: 38049620, PMCID: PMC11087147, DOI: 10.1038/s41591-023-02638-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryDeep brain stimulationExecutive controlProcessing speedBrain stimulationImprove executive controlCentral lateral (CL) nucleusTrail-Making TestChronic phase of recoveryBrain injuryYears post-injuryFrontostriatal networkEfficacy of deep brain stimulationExecutive functionConverging evidenceLimit quality of lifeEfficacy measuresMsTBIPhase of recoveryPost-injuryRandomized feasibility studyThalamic deep brain stimulationQuality of lifeParticipantsProtocol non-compliance
2022
Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation for Traumatic Brain Injury Study: Part I
Fins J, Wright M, Henderson J, Schiff N. Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation for Traumatic Brain Injury Study: Part I. Cambridge Quarterly Of Healthcare Ethics 2022, 31: 419-443. PMID: 36398511, DOI: 10.1017/s0963180122000226.Peer-Reviewed Original ResearchConceptsCentral thalamic deep brain stimulationVoluntary informed consentTraumatic brain injuryDecision-making authorityBrain injuryDeep brain stimulationTherapeutic misconceptionCognitive restorationBrain stimulationAgency of subjectsInformed consentSevere traumatic brain injuryTraumatic brain injury studiesThalamic deep brain stimulationConsentTreatment of traumatic brain injuryEnrollment decisionsBrain injury studiesFamily perspectiveInterpersonal interactionsDecisionCognitive disabilitiesStudy enrollmentReturn to workSocial structure
2012
Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities
Giacino J, Fins J, Machado A, Schiff N. Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities. Neuromodulation Technology At The Neural Interface 2012, 15: 339-349. PMID: 22624587, DOI: 10.1111/j.1525-1403.2012.00458.x.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain MappingClinical Trials as TopicDeep Brain StimulationElectrodes, ImplantedHumansInformed ConsentMonitoring, IntraoperativeNeuronavigationNeurosurgical ProceduresPatient Care PlanningPatient SelectionPersistent Vegetative StatePostoperative CareRecovery of FunctionThalamusConceptsTraumatic brain injuryCentral thalamic deep brain stimulationCT-DBSMinimally conscious stateThalamic deep brain stimulationOutcome measuresDeep brain stimulationSecondary outcome measuresIncreased functional communicationChronic minimally conscious stateBrain stimulationComa Recovery Scale-RevisedSingle-subject studySevere traumatic brain injuryImproved behavioral functionFunctional independenceObject namingWorking memoryConscious stateSustained attentionScale-RevisedBehavioral functionsFunctional communicationModulate arousalCentral thalamus
2007
Deep brain stimulation and cognition: moving from animal to patient
Schiff N, Fins J. Deep brain stimulation and cognition: moving from animal to patient. Current Opinion In Neurology 2007, 20: 638-642. PMID: 17992082, DOI: 10.1097/wco.0b013e3282f1c6e4.Peer-Reviewed Original ResearchConceptsCognitive functionBrain injuryDeep brain stimulationModulate cognitive functionsBrain stimulationCentral thalamic deep brain stimulationImpaired cognitive functionBehavioral improvementBrain electrical stimulationThalamic deep brain stimulationTherapeutic optionsBrainNonprogressive brain injuryArea of researchElectrical stimulationInjuryPatientsStimulationCognitionStudy design