2020
Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit
Edlow B, Barra M, Zhou D, Foulkes A, Snider S, Threlkeld Z, Chakravarty S, Kirsch J, Chan S, Meisler S, Bleck T, Fins J, Giacino J, Hochberg L, Solt K, Brown E, Bodien Y. Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit. Neurocritical Care 2020, 33: 364-375. PMID: 32794142, PMCID: PMC8336723, DOI: 10.1007/s12028-020-01062-7.Peer-Reviewed Original ResearchConceptsIntensive care unitPromote recovery of consciousnessRecovery of consciousnessIntravenous methylphenidateEarly recovery of consciousnessPromote early recoveryPhase 2aDrug-related adverse eventsCare unitAscending arousal networkEscalating daily dosesHighest tolerated doseAcute severe traumatic brain injuryDose-finding studyOutcome measuresBrain injurySerum half-lifeMaximal serum concentrationPrimary outcome measureWithdrawal of life-sustaining therapyDrug’s pharmacodynamic propertiesSecondary outcome measuresMagnetic resonance imagingOpen-labelPharmacodynamic criteria
2012
Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities
Giacino J, Fins J, Machado A, Schiff N. Central Thalamic Deep Brain Stimulation to Promote Recovery from Chronic Posttraumatic Minimally Conscious State: Challenges and Opportunities. Neuromodulation Technology At The Neural Interface 2012, 15: 339-349. PMID: 22624587, DOI: 10.1111/j.1525-1403.2012.00458.x.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain MappingClinical Trials as TopicDeep Brain StimulationElectrodes, ImplantedHumansInformed ConsentMonitoring, IntraoperativeNeuronavigationNeurosurgical ProceduresPatient Care PlanningPatient SelectionPersistent Vegetative StatePostoperative CareRecovery of FunctionThalamusConceptsTraumatic brain injuryCentral thalamic deep brain stimulationCT-DBSMinimally conscious stateThalamic deep brain stimulationOutcome measuresDeep brain stimulationSecondary outcome measuresIncreased functional communicationChronic minimally conscious stateBrain stimulationComa Recovery Scale-RevisedSingle-subject studySevere traumatic brain injuryImproved behavioral functionFunctional independenceObject namingWorking memoryConscious stateSustained attentionScale-RevisedBehavioral functionsFunctional communicationModulate arousalCentral thalamus
2008
Erratum: Behavioural improvements with thalamic stimulation after severe traumatic brain injury
Schiff N, Giacino J, Kalmar K, Victor J, Baker K, Gerber M, Fritz B, Eisenberg B, Biondi T, O’Connor J, Kobylarz E, Farris S, Machado A, McCagg C, Plum F, Fins J, Rezai A. Erratum: Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 2008, 452: 120-120. DOI: 10.1038/nature06818.Peer-Reviewed Original Research
1999
End-of-Life Decision-Making in the Hospital Current Practice and Future Prospects
Fins J, Miller F, Acres C, Bacchetta M, Huzzard L, Rapkin B. End-of-Life Decision-Making in the Hospital Current Practice and Future Prospects. Journal Of Pain And Symptom Management 1999, 17: 6-15. PMID: 9919861, DOI: 10.1016/s0885-3924(98)00109-2.Peer-Reviewed Original ResearchConceptsComfort care plansEnd-of-life decision-makingHospitalized dying patientsCare planningDNR ordersDo-not-resuscitate (DNRAssociated with DNR ordersCare Assessment ToolUrban academic medical centerHealth care proxyImprove practice patternsLife-sustaining treatmentEnd-of-lifeAcademic medical centerPalliative servicesPalliative careComfort careAdult deathsArtificial nutritionOutcome measuresPractice patternsAssessment toolChart review of patientsCareMedical Center