2024
Cognitive Motor Dissociation in Disorders of Consciousness
Bodien Y, Allanson J, Cardone P, Bonhomme A, Carmona J, Chatelle C, Chennu S, Conte M, Dehaene S, Finoia P, Heinonen G, Hersh J, Kamau E, Lawrence P, Lupson V, Meydan A, Rohaut B, Sanders W, Sitt J, Soddu A, Valente M, Velazquez A, Voss H, Vrosgou A, Claassen J, Edlow B, Fins J, Gosseries O, Laureys S, Menon D, Naccache L, Owen A, Pickard J, Stamatakis E, Thibaut A, Victor J, Giacino J, Bagiella E, Schiff N. Cognitive Motor Dissociation in Disorders of Consciousness. New England Journal Of Medicine 2024, 391: 598-608. PMID: 39141852, DOI: 10.1056/nejmoa2400645.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTask-based fMRICognitive motor dissociationDisorders of consciousnessComa Recovery Scale-RevisedCognitive tasksMotor dissociationObserved responseBrain injuryVerbal commandsBrain traumaScale-RevisedMagnetic resonance imagingDisordersBrainParticipantsEtiological factorsAssociated with younger ageElectroencephalographyCohort of personsResonance imagingProspective cohort studyTaskElectroencephalography dataMedian age
2023
Cognitive Motor Dissociation: Gap Analysis and Future Directions
Claassen J, Kondziella D, Alkhachroum A, Diringer M, Edlow B, Fins J, Gosseries O, Hannawi Y, Rohaut B, Schnakers C, Stevens R, Thibaut A, Monti M. Cognitive Motor Dissociation: Gap Analysis and Future Directions. Neurocritical Care 2023, 40: 81-98. PMID: 37349602, DOI: 10.1007/s12028-023-01769-3.Peer-Reviewed Original ResearchConceptsMethodsThe Neurocritical Care SocietyCognitive motor dissociationNeurocritical Care SocietyDisorders of consciousnessCare SocietyFunctional magnetic resonance imagingHealth care personnelEducational gapPotential prognostic relevanceCaregiver accountsManagement of patientsIdentification of patientsPatient experienceCare personnelInternational group of expertsUnmet needsMagnetic resonance imagingPrognostic significanceKnowledge gapsMethodological variablesTreatment trialsEpidemiological dataGroup of expertsClinical practiceLarge-scale implementation
2020
Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit
Edlow B, Barra M, Zhou D, Foulkes A, Snider S, Threlkeld Z, Chakravarty S, Kirsch J, Chan S, Meisler S, Bleck T, Fins J, Giacino J, Hochberg L, Solt K, Brown E, Bodien Y. Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit. Neurocritical Care 2020, 33: 364-375. PMID: 32794142, PMCID: PMC8336723, DOI: 10.1007/s12028-020-01062-7.Peer-Reviewed Original ResearchConceptsIntensive care unitPromote recovery of consciousnessRecovery of consciousnessIntravenous methylphenidateEarly recovery of consciousnessPromote early recoveryPhase 2aDrug-related adverse eventsCare unitAscending arousal networkEscalating daily dosesHighest tolerated doseAcute severe traumatic brain injuryDose-finding studyOutcome measuresBrain injurySerum half-lifeMaximal serum concentrationPrimary outcome measureWithdrawal of life-sustaining therapyDrug’s pharmacodynamic propertiesSecondary outcome measuresMagnetic resonance imagingOpen-labelPharmacodynamic criteria
2018
Assessment of Covert Consciousness in the Intensive Care Unit
Edlow B, Fins J. Assessment of Covert Consciousness in the Intensive Care Unit. Journal Of Head Trauma Rehabilitation 2018, 33: 424-434. PMID: 30395042, PMCID: PMC6317885, DOI: 10.1097/htr.0000000000000448.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTraumatic brain injuryAcute severe traumatic brain injurySevere traumatic brain injuryIntensive care unitCovert consciousnessEthical challengesIntensive care unit patientsTask-based functional magnetic resonance imagingTask-based fMRILife-sustaining therapyWithdrawal of life-sustaining therapyCare unitEthical frameworkBehavioral assessmentCritically ill patientsEvaluation normsMagnetic resonance imagingConsciousnessBrain injuryGoals of careClinical scenariosIll patientsRecovered consciousnessTreatment decisions
2011
Neuroethics, neuroimaging, and disorders of consciousness: promise or peril?
Fins J. Neuroethics, neuroimaging, and disorders of consciousness: promise or peril? Transactions Of The American Clinical And Climatological Association 2011, 122: 336-46. PMID: 21686236, PMCID: PMC3116331.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingDisorders of consciousnessPositron emission tomographyBehavior-based assessmentsMinimally conscious stateNeuroimaging dataNeuroimaging toolsBrain statesBrain injuryMagnetic resonance imagingNeuroimagingEmission tomographyConscious stateDisordersBrainResonance imagingNeuroimaging applicationsConsciousnessDiagnostic dilemmaTherapeutic useCommunication vectorNeuroethics