2024
Cognitive Motor Dissociation in Disorders of Consciousness
Bodien Y, Allanson J, Cardone P, Bonhomme A, Carmona J, Chatelle C, Chennu S, Conte M, Dehaene S, Finoia P, Heinonen G, Hersh J, Kamau E, Lawrence P, Lupson V, Meydan A, Rohaut B, Sanders W, Sitt J, Soddu A, Valente M, Velazquez A, Voss H, Vrosgou A, Claassen J, Edlow B, Fins J, Gosseries O, Laureys S, Menon D, Naccache L, Owen A, Pickard J, Stamatakis E, Thibaut A, Victor J, Giacino J, Bagiella E, Schiff N. Cognitive Motor Dissociation in Disorders of Consciousness. New England Journal Of Medicine 2024, 391: 598-608. PMID: 39141852, DOI: 10.1056/nejmoa2400645.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTask-based fMRICognitive motor dissociationDisorders of consciousnessComa Recovery Scale-RevisedCognitive tasksMotor dissociationObserved responseBrain injuryVerbal commandsBrain traumaScale-RevisedMagnetic resonance imagingDisordersBrainParticipantsEtiological factorsAssociated with younger ageElectroencephalographyCohort of personsResonance imagingProspective cohort studyTaskElectroencephalography dataMedian ageBrain injury, medical progress, and the disability paradox: Towards an Americans with Abilities Act
Fins J, Shulman K, Wright M, Shapiro Z. Brain injury, medical progress, and the disability paradox: Towards an Americans with Abilities Act. Neurorehabilitation 2024, 54: 141-147. PMID: 38217618, DOI: 10.3233/nre-230118.Peer-Reviewed Original ResearchConceptsDisability lawLegal protection of patientsInterface of medicineProtection of patientsAmerican jurisprudenceConstitutional protectionLegal protectionLawConstitutive elementsNewfound abilityMedical progressProtectionJurisprudenceLegislationBrain injuryAmericanModerate to severe brain injuryDisabilityParadoxBrain injury professionalsProfessionalsADASevere brain injuryBrain
2022
Syndromes in Search of a Name: Disorders of Consciousness, Neuroethics, and Nosological Humility
Fins J. Syndromes in Search of a Name: Disorders of Consciousness, Neuroethics, and Nosological Humility. 2022, 163-175. DOI: 10.1007/978-3-031-04935-4_18.Peer-Reviewed Original ResearchDisorders of consciousnessBrain injuryCognitive motor dissociationStruggle for ConsciousnessRecognition of consciousnessVegetative stateDiagnostic categorizationLimits of knowledgePermanent vegetative stateNosologyPersistent vegetative stateMotor dissociationCovert consciousnessNormative importanceBrainDisordersChronic vegetative stateConsciousnessSocial integrationHumilityEvolving storyNeuroimagingNeuroscienceMindfulnessRightsTowards a Governance Framework for Brain Data
Ienca M, Fins J, Jox R, Jotterand F, Voeneky S, Andorno R, Ball T, Castelluccia C, Chavarriaga R, Chneiweiss H, Ferretti A, Friedrich O, Hurst S, Merkel G, Molnár-Gábor F, Rickli J, Scheibner J, Vayena E, Yuste R, Kellmeyer P. Towards a Governance Framework for Brain Data. Neuroethics 2022, 15: 20. DOI: 10.1007/s12152-022-09498-8.Peer-Reviewed Original ResearchCognitive-Motor Dissociation Following Pediatric Brain Injury
Kim N, O'Sullivan J, Olafson E, Caliendo E, Nowak S, Voss H, Lowder R, Watson W, Ivanidze J, Fins J, Schiff N, Hill N, Shah S. Cognitive-Motor Dissociation Following Pediatric Brain Injury. Neurology Clinical Practice 2022, 12: 248-257. PMID: 35733619, PMCID: PMC9208423, DOI: 10.1212/cpj.0000000000001169.Peer-Reviewed Original ResearchCognitive-motor dissociationCognitive functionParticipants' EEGSemantic processing of wordsCovert cognitionBrain injuryProcessing of wordsIntact semantic processingIdentifying such personsResponses to auditory stimuliDiverse batteryCognitive abilitiesMinimally conscious stateCognitive-motorCognitive capacityPediatric brain injuryCommunication attemptsAuditory stimuliAged 9CognitionNeuroimagingMotor outputConscious stateParticipantsBrain
2016
Brain death and disorders of consciousness
Schiff N, Fins J. Brain death and disorders of consciousness. Current Biology 2016, 26: r572-r576. PMID: 27404252, DOI: 10.1016/j.cub.2016.02.027.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessBrain-dead patientsBrain deathVegetative stateCognitive motor dissociationScientific knowledgeCognitive functionMinimally conscious stateNon-medical specialistsSocietal contextBrain statesConsciousnessConscious stateMotor dissociationBrainDisordersDead patientsConceptual frameworkLack of sustainabilityHigher levelsFutilityParadoxDistinctionChapter 15 Neuroethics and Disorders of Consciousness A Pragmatic Approach to Neuropalliative Care
Fins J. Chapter 15 Neuroethics and Disorders of Consciousness A Pragmatic Approach to Neuropalliative Care. 2016, 241-252. DOI: 10.1016/b978-0-12-800948-2.00015-7.Peer-Reviewed Original ResearchBrain damageMystery of consciousnessDisorders of consciousnessImpaired decision-making capacityClinical pragmatismDecision-making capacityHuman rights issuesAmerican pragmatic traditionBrain injuryMoral problemsBrainRights issuesDisordersClinical contextHuman consciousnessEthical challengesConsciousnessComplexity of researchArgument IImpaired consciousness
2015
Ethics of neuromodulation in psychiatry
Fins J, Pohl B. Ethics of neuromodulation in psychiatry. 2015, 15-26. DOI: 10.1002/9781118801086.ch2.Peer-Reviewed Original ResearchSevere psychiatric illnessHealth care systemNeuropsychiatric conditionsPsychiatric illnessPervasive stigmaMental illnessCare systemDeep brain stimulationBrain stimulationClinical ethicsMoral dilemmasDerivative questionsIllnessEthicsDevice regulationNeuromodulationTranslational researchClinical needPsychiatryStigmaHealthBrainInterventionRights Come to Mind
Fins J. Rights Come to Mind. 2015 DOI: 10.1017/cbo9781139051279.Peer-Reviewed Original Research
2013
Surrogate expectations in severe brain injury
Suppes A, Fins J. Surrogate expectations in severe brain injury. Brain Injury 2013, 27: 1141-1147. PMID: 23895513, PMCID: PMC5454804, DOI: 10.3109/02699052.2013.804201.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdvance Care PlanningAdvance DirectivesBrain InjuriesCaregiversChildComaDecision MakingFamilyFemaleGriefHumansIntensive Care UnitsMaleMiddle AgedNew YorkPersistent Vegetative StatePhysician's RoleProfessional-Family RelationsPrognosisProxySeverity of Illness IndexStress, PsychologicalConceptsSource of injuryExpectations of recoveryPsychosocial featuresDecision-making expectationsQuantitative questionnaireImprove treatment of patientsFamily membersPatient recoveryTreatment of patientsPatient diagnosisRelated factorsDOC patientsBrain injuryPatientsImproved treatmentInjuryCurrent diagnosisExpectationsQuestionnaireDiagnosisCliniciansBrainSurveyFactorsDisorders of Consciousness Following Severe Brain Injury
Fins J, Schiff N. Disorders of Consciousness Following Severe Brain Injury. 2013, 162-174. DOI: 10.1093/acprof:oso/9780195389784.003.0013.Peer-Reviewed Original ResearchDisorders of consciousnessBrain statesInterviews of familiesTraditional nosologyBehavioral measuresFunctional communicationMinimally conscious stateNeuroimaging dataDiagnostic classificationMeasures of assessmentBrain injuryDisordersConscious stateBrainFamily experiencesClinical practiceNeuroimagingNosology
2011
Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury
Bardin J, Fins J, Katz D, Hersh J, Heier L, Tabelow K, Dyke J, Ballon D, Schiff N, Voss H. Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury. Brain 2011, 134: 769-782. PMID: 21354974, PMCID: PMC3044833, DOI: 10.1093/brain/awr005.Peer-Reviewed Original ResearchConceptsBrain-injured subjectsBlood oxygen level-dependent responsesBrain-injured patientsCognitive functionFunctional magnetic resonance imaging assessmentsEvaluation of cognitive functionFunctional neuroimaging methodsOvert behavioral responsesSeverely brain-injured patientsNeuroimaging methodsBrain functionBehavioral responsesBrain injuryMagnetic resonance imaging-based methodMotor functionControl groupBrainMagnetic resonance imaging assessmentSubjectsClinical useImaging assessmentResponseNeuroethics, neuroimaging, and disorders of consciousness: promise or peril?
Fins J. Neuroethics, neuroimaging, and disorders of consciousness: promise or peril? Transactions Of The American Clinical And Climatological Association 2011, 122: 336-46. PMID: 21686236, PMCID: PMC3116331.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingDisorders of consciousnessPositron emission tomographyBehavior-based assessmentsMinimally conscious stateNeuroimaging dataNeuroimaging toolsBrain statesBrain injuryMagnetic resonance imagingNeuroimagingEmission tomographyConscious stateDisordersBrainResonance imagingNeuroimaging applicationsConsciousnessDiagnostic dilemmaTherapeutic useCommunication vectorNeuroethics
2008
Neuroethics and Neuroimaging: Moving Toward Transparency
Fins J. Neuroethics and Neuroimaging: Moving Toward Transparency. The American Journal Of Bioethics 2008, 8: 46-52. PMID: 18853386, DOI: 10.1080/15265160802334490.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessDiagnostic nosologyNeural mechanismsMinimally conscious stateWorking brainDiagnostic categoriesNeuroimaging findingsTherapeutic agendaDiagnostic refinementNeuroimagingAge of neuroscienceMechanisms of recoveryBrain injuryAssessment ScaleTranslation of research findingsDisordersBrainConscious stateEthical conduct of researchClinical contextConduct of researchResearch findingsFunctional levelEthical conductNosology
2007
Deep brain stimulation and cognition: moving from animal to patient
Schiff N, Fins J. Deep brain stimulation and cognition: moving from animal to patient. Current Opinion In Neurology 2007, 20: 638-642. PMID: 17992082, DOI: 10.1097/wco.0b013e3282f1c6e4.Peer-Reviewed Original ResearchConceptsCognitive functionBrain injuryDeep brain stimulationModulate cognitive functionsBrain stimulationCentral thalamic deep brain stimulationImpaired cognitive functionBehavioral improvementBrain electrical stimulationThalamic deep brain stimulationTherapeutic optionsBrainNonprogressive brain injuryArea of researchElectrical stimulationInjuryPatientsStimulationCognitionStudy design
2005
Clinical pragmatism and the care of brain damaged patients: toward a palliative neuroethics for disorders of consciousness
Fins J. Clinical pragmatism and the care of brain damaged patients: toward a palliative neuroethics for disorders of consciousness. Progress In Brain Research 2005, 150: 565-582. PMID: 16186050, DOI: 10.1016/s0079-6123(05)50040-2.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessClinical pragmatismBrain-damaged patientsBrain damageMystery of consciousnessDamaged patientsImpaired decision-making capacityDecision-making capacityAmerican pragmatic traditionBrain injuryProblem-solvingBrainMoral problem-solvingDisordersClinical contextHuman consciousnessConsciousnessImpaired consciousnessPragmaticsClinical careAversionSocietal contextSelfPalliative careResearch
2004
Protecting human subjects in brain research: a pragmatic perspective
Miller F, Fins J. Protecting human subjects in brain research: a pragmatic perspective. 2004, 123-140. DOI: 10.1093/acprof:oso/9780198567219.003.0009.Peer-Reviewed Original ResearchAmerican philosophical pragmatismEthical judgmentsMoral principlesMoral normsPhilosophical pragmatismResearch ethicsAbsolute ruleEthical considerationsRelevant considerationsPragmatic perspectiveBrain researchTrials of pharmacological treatmentsPlacebo-controlled trialDeep brain stimulationBrain disordersPharmacological treatmentEthicsPragmaticsHuman subjectsJudgmentDisordersBrainConsiderationsComplex situationsNeurological disorders
2003
Constructing an ethical stereotaxy for severe brain injury: balancing risks, benefits and access
Fins J. Constructing an ethical stereotaxy for severe brain injury: balancing risks, benefits and access. Nature Reviews Neuroscience 2003, 4: 323-327. PMID: 12671648, DOI: 10.1038/nrn1079.Peer-Reviewed Original Research