Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.
Capurso NA, Look M, Jeanbart L, Nowyhed H, Abraham C, Craft J, Fahmy TM. Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells. Self/Nonself 2010, 1: 335-340. PMID: 21487509, PMCID: PMC3062389, DOI: 10.4161/self.1.4.13946.Peer-Reviewed Original ResearchUse of nanoparticlesDrug delivery platformDrug delivery vehiclesBiodegradable nanoparticlesNanoparticulate formulationT cellsDelivery platformDelivery vehiclesNanoparticlesRA deliverySurface modificationExciting technologyRetinoic acidTh17 phenotypeInflammatory diseasesFree drugSimilar potencyIL-17 productionSpecific cell typesRegulatory T cellsIL-10 productionIL-6 productionPromising approachDecrease toxicityTreg phenotype