2004
Activation of Naive CD4+ T Cells In Vivo by a Self-Peptide Mimic: Mechanism of Tolerance Maintenance and Preservation of Immunity
Choi JY, Craft J. Activation of Naive CD4+ T Cells In Vivo by a Self-Peptide Mimic: Mechanism of Tolerance Maintenance and Preservation of Immunity. The Journal Of Immunology 2004, 172: 7399-7407. PMID: 15187117, DOI: 10.4049/jimmunol.172.12.7399.Peer-Reviewed Original ResearchConceptsSelf peptide-MHC complexesT cellsTolerance maintenanceCostimulatory signalsMHC complexesNaive T cellsTCR engagementIntrathymic selectionNaive CD4Peripheral repertoireStrong costimulationForeign AgsAgonist peptideMicrobial challengeSurviving cellsNovel mechanismCellsVivoSubsequent encountersLow affinityPathogen challengeDividing cellsCD4CD69Restimulation
2003
CD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo
Bouzahzah F, Jung S, Craft J. CD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo. The Journal Of Immunology 2003, 170: 741-748. PMID: 12517936, DOI: 10.4049/jimmunol.170.2.741.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAutoantigensCD4-Positive T-LymphocytesCell DivisionCell SeparationCells, CulturedClonal AnergyEpitopes, T-LymphocyteGenetic Predisposition to DiseaseLupus NephritisLymphocyte CountMiceMice, Inbred C57BLMice, Inbred CBAMice, Inbred MRL lprMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaConceptsPigeon cytochrome cT cellsIL-2Self-AgCostimulatory signalsAntigen-specific tolerance inductionMRL xTCR transgenic T cellsLupus-prone MRL miceMRL T cellsNormal tolerance mechanismsUbiquitous self-AgsVivo Ag stimulationLupus-prone miceSuch T cellsPeripheral tolerance mechanismsCBA/CaJControl T cellsEx vivo recall assaysActivated T cellsT cell activationInappropriate T-cell activationThymic toleranceMRL/Recall assays