1996
Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses.
Ma J, Xu J, Madaio MP, Peng Q, Zhang J, Grewal IS, Flavell RA, Craft J. Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses. The Journal Of Immunology 1996, 157: 417-26. PMID: 8683147, DOI: 10.4049/jimmunol.157.1.417.Peer-Reviewed Original ResearchConceptsLpr/lpr miceLpr miceIgG autoantibodiesAutoantibody responseCD40 ligandAutoimmune lpr/lpr miceMRL/Mp-lpr/lpr miceHuman systemic lupus erythematosusSystemic lupus erythematosusAge 3 moIgG rheumatoid factorB cell contactSubset of animalsOvert glomerulonephritisLupus erythematosusIgG2b levelsHistologic evidenceRheumatoid factorSerum IgMAb synthesisAutoantibodiesLpr animalsMiceIg classesElevated levels
1994
B cells process and present lupus autoantigens that initiate autoimmune T cell responses.
Mamula MJ, Fatenejad S, Craft J. B cells process and present lupus autoantigens that initiate autoimmune T cell responses. The Journal Of Immunology 1994, 152: 1453-61. PMID: 8301145, DOI: 10.4049/jimmunol.152.3.1453.Peer-Reviewed Original ResearchConceptsT cell responsesAutoimmune T cell responsesT cellsCell responsesB cellsAnti-snRNP antibodiesCross-reactive B cellsNon-autoimmune miceT cell toleranceB-cell processesSera of humansCross-reactive determinantsNative snRNP particlesMouse AgAutoreactive CD4Naive miceAutoantibody responseAutoreactive cellsMurine lupusTh cellsCommon findingSelf-AgCell toleranceMolecular mimicryMice
1993
Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles.
Fatenejad S, Mamula MJ, Craft J. Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 12010-12014. PMID: 8265662, PMCID: PMC48115, DOI: 10.1073/pnas.90.24.12010.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoreactive T cellsLupus erythematosusT cellsAutoantibody productionSuch miceAutoreactive helper T cellsHelper T-cell determinantsHelper T cellsT cell determinantsAutoantibody responseAutoimmune responseAntibody responseNormal miceImmune responseB cellsAutoantibodiesErythematosusMiceCentral targetPatientsImmunizationSnRNP particlesCellsMolecular mimics