2006
Idiopathic Epicardial Left Ventricular Tachycardia Originating Remote From the Sinus of Valsalva
Daniels DV, Lu YY, Morton JB, Santucci PA, Akar JG, Green A, Wilber DJ. Idiopathic Epicardial Left Ventricular Tachycardia Originating Remote From the Sinus of Valsalva. Circulation 2006, 113: 1659-1666. PMID: 16567566, DOI: 10.1161/circulationaha.105.611640.Peer-Reviewed Original ResearchConceptsIdiopathic ventricular tachycardiaMaximum deflection indexVentricular tachycardiaEpicardial ventricular tachycardiaDirect surgical ablationSinus of ValsalvaLeft ventricular epicardiumDeflection indexSite of originUnsuccessful ablationAortic sinusVenous mappingCatheter ablationOccasional patientSurgical ablationCoronary veinVT inductionTranspericardial approachVentricular sitesEndocardial activationEpicardial mappingPerivascular sitesECG patternVentricular endocardiumAnatomic constraints
2003
Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial Fibrillation
Akar JG, Everett TH, Ho R, Craft J, Haines DE, Somlyo AP, Somlyo AV. Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial Fibrillation. Circulation 2003, 107: 1810-1815. PMID: 12665494, DOI: 10.1161/01.cir.0000058462.23347.93.Peer-Reviewed Original ResearchConceptsEffective refractory periodLeft atrial appendageAtrial fibrillationMitochondrial Ca overloadWhole-cell ClWhole-cell NaIntracellular chloride accumulationIntracellular Cl- accumulationSinus rhythmAtrial appendageCa overloadElectrical remodelingAF pathogenesisRapid pacingRefractory periodTransient increaseTransverse cryosectionsMembrane depolarizationFibrillationNovel findingsCytosolic CaCytoplasmic CaConcomitant increaseIon channelsMinutes