2023
Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring
Ginder C, Li J, Halperin J, Akar J, Martin D, Chattopadhyay I, Upadhyay G. Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring. Journal Of The American College Of Cardiology 2023, 81: 949-961. PMID: 36889873, DOI: 10.1016/j.jacc.2022.12.024.Peer-Reviewed Original ResearchConceptsAppropriate device therapyMalignant ventricular arrhythmiasDevice therapyVentricular arrhythmiasImplantable cardioverter-defibrillator therapyLogistic regressionSeparate multivariable logistic regressionsLead impedanceAppropriate ICD therapyCardioverter-defibrillator therapyCardiac resynchronization therapyMultivariable logistic regressionRemote monitoring dataShock lead impedanceAtrial lead impedanceICD therapyHeart failureResynchronization therapyAppropriate therapyAtrial tachyarrhythmiasVentricular tachycardiaVentricular fibrillationDefibrillator devicesHeart ratePatients
2017
Arrhythmias after left ventricular assist device implantation: Incidence and management
Kadado AJ, Akar JG, Hummel JP. Arrhythmias after left ventricular assist device implantation: Incidence and management. Trends In Cardiovascular Medicine 2017, 28: 41-50. PMID: 28734595, DOI: 10.1016/j.tcm.2017.07.002.Peer-Reviewed Original ResearchConceptsLeft ventricular assist deviceMechanical circulatory supportVentricular arrhythmiasCirculatory supportContinuous-flow devicesVentricular assist device implantationAssist device implantationNewer-generation continuous-flow devicesHeart failure patientsVentricular assist deviceImplant ICDsFailure patientsHemodynamic supportLVAD recipientsHeart failureDevice implantationFatal outcomeDestination therapySudden deathLethal arrhythmiasMortality ratePatientsArrhythmiasAssist deviceLVAD device
2009
Prospective Study of Cardiac Sarcoid Mimicking Arrhythmogenic Right Ventricular Dysplasia
VASAIWALA SC, FINN C, DELPRIORE J, LEYA F, GAGERMEIER J, AKAR JG, SANTUCCI P, DAJANI K, BOVA D, PICKEN MM, BASSO C, MARCUS F, WILBER DJ. Prospective Study of Cardiac Sarcoid Mimicking Arrhythmogenic Right Ventricular Dysplasia. Journal Of Cardiovascular Electrophysiology 2009, 20: 473-476. PMID: 19017339, DOI: 10.1111/j.1540-8167.2008.01351.x.Peer-Reviewed Original ResearchConceptsARVD/CLeft ventricular dysfunctionARVD/C.Cardiac sarcoidMagnetic resonance imagingVentricular dysfunctionProspective studyVentricular arrhythmiasArrhythmogenic right ventricular dysplasia/cardiomyopathyRight ventricular dysplasia/cardiomyopathyDefinite ARVD/CVentricular dysplasia/cardiomyopathyLeft bundle branch blockInternational Task Force criteriaTask Force criteriaBundle branch blockChest X-rayProbable ARVD/CBiopsy consistentRV functionClinical predictorsConsecutive patientsClinical featuresClinical presentationHistological findings
2007
Regulation of ion channels and arrhythmias in the ischemic heart
Akar JG, Akar FG. Regulation of ion channels and arrhythmias in the ischemic heart. Journal Of Electrocardiology 2007, 40: s37-s41. PMID: 17993326, DOI: 10.1016/j.jelectrocard.2007.05.020.Peer-Reviewed Original ResearchConceptsIschemic injuryElectrophysiological changesIschemic heart diseaseBest treatment strategyCoronary eventsReperfusion phaseVentricular arrhythmiasIschemic episodesHeart diseaseLeading causeElectrical dysfunctionTreatment strategiesIschemic heartMetabolic substratesPatientsArrhythmiasKey cellularTime courseInjuryIon channelsHeartDysfunctionMortalityDisease
2006
Mapping arrhythmias in the failing heart: from Langendorff to patient
Akar JG, Akar FG. Mapping arrhythmias in the failing heart: from Langendorff to patient. Journal Of Electrocardiology 2006, 39: s19-s23. PMID: 16920143, DOI: 10.1016/j.jelectrocard.2006.03.011.Peer-Reviewed Educational MaterialsConceptsHeart failureVentricular arrhythmiasOptical action potential mappingSudden cardiac deathCardiac deathIntact tissue preparationsCardiac remodelingMost arrhythmiasArrhythmic substrateArrhythmiasElectrophysiological propertiesMapping arrhythmiasTissue levelsIndividual myocytesMajor causeReentrant excitationOrgan system levelPatientsMultiple mechanismsTissue preparationsHeartRecent findingsHost of changesCellular studiesLangendorff