2021
B-PO02-027 RIGHT PREDOMINANT ELECTRICAL REMODELING IN A PURE MODEL OF PULMONARY HYPERTENSION PROMOTES REENTRANT ARRHYTHMIAS
Strauss B, Obus E, Katz M, Fargnoli A, Cacheux M, Akar J, Hummel J, Sassi Y, Akar F. B-PO02-027 RIGHT PREDOMINANT ELECTRICAL REMODELING IN A PURE MODEL OF PULMONARY HYPERTENSION PROMOTES REENTRANT ARRHYTHMIAS. Heart Rhythm 2021, 18: s106. DOI: 10.1016/j.hrthm.2021.06.284.Peer-Reviewed Original Research
2017
Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
Karam BS, Chavez-Moreno A, Koh W, Akar JG, Akar FG. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovascular Diabetology 2017, 16: 120. PMID: 28962617, PMCID: PMC5622555, DOI: 10.1186/s12933-017-0604-9.Peer-Reviewed Original ResearchConceptsAtrial fibrillationOxidative stressCommon sustained cardiac arrhythmiaMaintenance of AFSustained cardiac arrhythmiaDiabetic heartElectrical remodelingRisk factorsAtrial excitabilityTherapeutic strategiesCardiac arrhythmiasInflammationCentral mediatorObesityDiabetesFibrillationMechanistic linkMellitusArrhythmiasExcitability
2003
Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial Fibrillation
Akar JG, Everett TH, Ho R, Craft J, Haines DE, Somlyo AP, Somlyo AV. Intracellular Chloride Accumulation and Subcellular Elemental Distribution During Atrial Fibrillation. Circulation 2003, 107: 1810-1815. PMID: 12665494, DOI: 10.1161/01.cir.0000058462.23347.93.Peer-Reviewed Original ResearchConceptsEffective refractory periodLeft atrial appendageAtrial fibrillationMitochondrial Ca overloadWhole-cell ClWhole-cell NaIntracellular chloride accumulationIntracellular Cl- accumulationSinus rhythmAtrial appendageCa overloadElectrical remodelingAF pathogenesisRapid pacingRefractory periodTransient increaseTransverse cryosectionsMembrane depolarizationFibrillationNovel findingsCytosolic CaCytoplasmic CaConcomitant increaseIon channelsMinutes
2002
Effect of Electrical and Structural Remodeling on Spatiotemporal Organization in Acute and Persistent Atrial Fibrillation
AKAR JG, EVERETT TH, KOK L, MOORMAN JR, HAINES DE. Effect of Electrical and Structural Remodeling on Spatiotemporal Organization in Acute and Persistent Atrial Fibrillation. Journal Of Cardiovascular Electrophysiology 2002, 13: 1027-1034. PMID: 12435191, DOI: 10.1046/j.1540-8167.2002.01027.x.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsAtrial FibrillationAtrial FunctionDisease Models, AnimalDogsElectrocardiographyElectrophysiologic Techniques, CardiacEntropyFemaleFollow-Up StudiesHeart AtriaModels, CardiovascularRecovery of FunctionRefractory Period, ElectrophysiologicalSeverity of Illness IndexStatistics as TopicTreatment OutcomeConceptsAtrial effective refractory periodPersistent atrial fibrillationAcute atrial fibrillationAtrial fibrillationStructural remodelingSinus rhythmMean atrial effective refractory periodEffective refractory periodAtrial sizeElectrical remodelingLeft atriumBasket catheterAF dogsIntracardiac echocardiographyAtrial electrogramsRefractory periodRemodelingFibrillationSpatiotemporal organizationRhythmAcuteEchocardiographyCatheterMajor roleRecovery