2021
Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases
Gutierrez MJ, Perez GF, Gomez JL, Rodriguez‐Martinez C, Castro‐Rodriguez J, Nino G. Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases. Pediatric Pulmonology 2021, 56: 3157-3165. PMID: 34388306, PMCID: PMC8858026, DOI: 10.1002/ppul.25598.Peer-Reviewed Original ResearchConceptsDevelopmental timingHistone modificationsPotential molecular mechanismsEpigenetic paradigmEpigenetic reprogrammingGenetic reprogrammingDevelopmental programDNA methylationMolecular mechanismsMolecular programmingReprogrammingEarly originsGenesLatest insightsNew insightsOmicsMethylationMicroRNAsHomeostasisLife-long consequencesInsightsTranslational approachRespiratory mucosaRespiratory diseaseCurrent evidence
2020
Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients
Spakowicz D, Lou S, Barron B, Gomez JL, Li T, Liu Q, Grant N, Yan X, Hoyd R, Weinstock G, Chupp GL, Gerstein M. Approaches for integrating heterogeneous RNA-seq data reveal cross-talk between microbes and genes in asthmatic patients. Genome Biology 2020, 21: 150. PMID: 32571363, PMCID: PMC7310008, DOI: 10.1186/s13059-020-02033-z.Peer-Reviewed Original Research
2018
Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life
Nino C, Perez G, Isaza N, Gutierrez M, Gomez J, Nino G. Characterization of Sex-Based Dna Methylation Signatures in the Airways During Early Life. Scientific Reports 2018, 8: 5526. PMID: 29615635, PMCID: PMC5882800, DOI: 10.1038/s41598-018-23063-5.Peer-Reviewed Original ResearchConceptsX-linked genesDNA methylation signaturesDifferential methylationMethylation signaturesGenome-wide DNA methylationProtein coding transcriptsX chromosome dosageX-chromosome methylationEpigenomic marksMethylation patternsX chromosomeDNA methylationCpG sitesGenomic signaturesX-inactivationGenetic componentCoding transcriptsGenesMethylation signalsAirways of infantsInfants aged 1Independent populationsRespiratory phenotypeAirway expressionIndividual's sex