2012
The Efficacies of 2 Ceramic Bone Graft Extenders for Promoting Spinal Fusion in a Rabbit Bone Paucity Model
Miller CP, Jegede K, Essig D, Garg H, Bible JE, Biswas D, Whang PG, Grauer JN. The Efficacies of 2 Ceramic Bone Graft Extenders for Promoting Spinal Fusion in a Rabbit Bone Paucity Model. Spine 2012, 37: 642-647. PMID: 21857402, DOI: 10.1097/brs.0b013e31822e604e.Peer-Reviewed Original Research
2010
Augmented demineralized bone matrix: a potential alternative for posterolateral lumbar spinal fusion.
Biswas D, Bible JE, Whang PH, Miller CP, Jaw R, Miller S, Grauer JN. Augmented demineralized bone matrix: a potential alternative for posterolateral lumbar spinal fusion. The American Journal Of Orthopedics 2010, 39: 531-8. PMID: 21623419.Peer-Reviewed Original ResearchConceptsFusion rateGraft alternativesPosterolateral lumbar spinal fusionLumbar spinal fusionRhBMP-2Spine fusion modelDose-response curveEctopic bone formation modelBone graft alternativesStudy ratsLumbar fusionRat modelSpinal fusionSpine fusionB graftsRecombinant human bone morphogenetic protein-2Manual palpationHuman bone morphogenetic protein-2Bone matrix productsSignificant differencesProtein 2DBM carrierBone matrixAutograftBone morphogenetic protein-2
2009
Effects of recombinant human bone morphogenetic protein 2 on surgical infections in a rabbit posterolateral lumbar fusion model.
Miller CP, Simpson AK, Whang PG, Erickson BP, Waked WR, Lawrence JP, Grauer JN. Effects of recombinant human bone morphogenetic protein 2 on surgical infections in a rabbit posterolateral lumbar fusion model. The American Journal Of Orthopedics 2009, 38: 578-84. PMID: 20049353.Peer-Reviewed Original ResearchConceptsLocal infectionRecombinant human bone morphogenetic proteinEarly deathRabbit posterolateral lumbar fusion modelPosterolateral lumbar fusion modelRhBMP-2Postoperative infectionSurgical infectionsSpine surgeryAutograft groupSpinal arthrodesisSterile salineFusion rateAutograftRecombinant human bone morphogenetic protein-2InfectionHuman bone morphogenetic proteinHuman bone morphogenetic protein-2Bone formationProtein 2Staphylococcus aureusRabbitsBone morphogenetic protein-2Bone morphogenetic proteinMorphogenetic protein-2
2008
125I-labeled OP-1 is Locally Retained in a Rabbit Lumbar Fusion Model
Erickson BP, Pierce AR, Simpson AK, Nash J, Grauer JN. 125I-labeled OP-1 is Locally Retained in a Rabbit Lumbar Fusion Model. Clinical Orthopaedics And Related Research® 2008, 466: 210-215. PMID: 18196395, PMCID: PMC2505306, DOI: 10.1007/s11999-007-0017-2.Peer-Reviewed Original Research
2007
rhBMP-2 (ACS and CRM Formulations) Overcomes Pseudarthrosis in a New Zealand White Rabbit Posterolateral Fusion Model
Lawrence JP, Waked W, Gillon TJ, White AP, Spock CR, Biswas D, Rosenberger P, Troiano N, Albert TJ, Grauer JN. rhBMP-2 (ACS and CRM Formulations) Overcomes Pseudarthrosis in a New Zealand White Rabbit Posterolateral Fusion Model. Spine 2007, 32: 1206-1213. PMID: 17495777, DOI: 10.1097/brs.0b013e318054721e.Peer-Reviewed Original ResearchAnimalsBone Morphogenetic Protein 2Bone Morphogenetic ProteinsBone SubstitutesBone TransplantationChemistry, PharmaceuticalDisease Models, AnimalDrug CarriersFemaleHumansIliumLumbar VertebraeNicotineOsseointegrationPseudarthrosisRabbitsRecombinant ProteinsSpinal FusionTime FactorsTomography, X-Ray ComputedTransforming Growth Factor betaTransplantation, Autologous
2006
Osteogenic Protein-1 Induced Gene Expression: Evaluation in a Posterolateral Spinal Pseudarthrosis Model
White AP, Maak TG, Prince D, Vaccaro AR, Albert TJ, Hilibrand AS, Grauer JN. Osteogenic Protein-1 Induced Gene Expression: Evaluation in a Posterolateral Spinal Pseudarthrosis Model. Spine 2006, 31: 2550-2555. PMID: 17047543, DOI: 10.1097/01.brs.0000240713.24367.42.Peer-Reviewed Original ResearchConceptsGene expressionOsteogenic protein-1Protein 1Differential gene expressionGlyceraldehyde-3-phosphate dehydrogenaseGene expression dataBone morphogenetic protein-2Morphogenetic protein-2Platelet-derived growthExpression dataTranscriptase-polymerase chain reactionPolymerase chain reactionMolecular studiesProtein 2Messenger ribonucleic acidRibonucleic acidChain reactionAdhesion moleculesCytokine gene expressionExpressionGrowth factorVascular endothelial growth factorEnhanced levelsEndothelial growth factorReverse transcriptase-polymerase chain reactionHealos/Recombinant Human Growth and Differentiation Factor-5 Induces Posterolateral Lumbar Fusion in a New Zealand White Rabbit Model
Magit DP, Maak T, Trioano N, Raphael B, Hamouria Q, Polzhofer G, Drespe I, Albert TJ, Grauer JN. Healos/Recombinant Human Growth and Differentiation Factor-5 Induces Posterolateral Lumbar Fusion in a New Zealand White Rabbit Model. Spine 2006, 31: 2180-2188. PMID: 16946651, DOI: 10.1097/01.brs.0000232823.82106.0a.Peer-Reviewed Original ResearchConceptsRecombinant human growthDifferentiation factor 5Fusion ratePosterolateral lumbar spine fusionPosterolateral lumbar fusionIliac crest autograftLumbar spine fusionNew Zealand white rabbitsNew Zealand white rabbit modelZealand white rabbitsRabbit fusion modelWhite rabbit modelIntertransverse process fusionBone graft alternativesCrest autograftLumbar fusionBACKGROUND DATAHistologic differencesPreclinical studiesSpine fusionTreatment groupsFactor 5Histologic analysisBone graftFusion massEffect of daily parathyroid hormone (1–34) on lumbar fusion in a rat model
Lawrence JP, Ennis F, White AP, Magit D, Polzhofer G, Drespe I, Troiano NW, Grauer JN. Effect of daily parathyroid hormone (1–34) on lumbar fusion in a rat model. The Spine Journal 2006, 6: 385-390. PMID: 16825043, DOI: 10.1016/j.spinee.2005.10.010.Peer-Reviewed Original ResearchConceptsSerum osteocalcin levelsParathyroid hormoneOsteocalcin levelsFusion rateDaily injectionsManual palpationLumbar fusionRat modelIntertransverse process spinal fusionDaily parathyroid hormoneSpinal fusion outcomesPosterolateral lumbar fusionIliac crest autograftSprague-Dawley ratsPreclinical animal studiesGreater fusion rateGreat clinical valuePlacebo groupIntermittent administrationSerum osteocalcinCrest autograftAnabolic effectsSpinal fusionInjectable agentsClinical value
2005
Animal models for spinal fusion
Drespe IH, Polzhofer GK, Turner AS, Grauer JN. Animal models for spinal fusion. The Spine Journal 2005, 5: s209-s216. PMID: 16291115, DOI: 10.1016/j.spinee.2005.02.013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSummary statement: biologics for spine fusion
Grauer JN, Jenis LG, Wang JC, Shen FH, Fischgrund JS, Phillips FM. Summary statement: biologics for spine fusion. The Spine Journal 2005, 5: s259. PMID: 16291121, DOI: 10.1016/j.spinee.2005.02.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2004
Comparison of Posterolateral Lumbar Fusion Rates of Grafton Putty and OP-1 Putty in an Athymic Rat Model
Bomback DA, Grauer JN, Lugo R, Troiano N, Patel TCh, Friedlaender GE. Comparison of Posterolateral Lumbar Fusion Rates of Grafton Putty and OP-1 Putty in an Athymic Rat Model. Spine 2004, 29: 1612-1617. PMID: 15284503, DOI: 10.1097/01.brs.0000132512.53305.a1.Peer-Reviewed Original ResearchConceptsOP-1 PuttyFusion rateSpine fusion modelManual palpationOP-1Posterolateral lumbar spine fusionLumbar spine fusionSimilar fusion ratesAthymic nude ratsSpine fusion ratesLumbar fusion ratesAthymic rat modelIntertransverse process fusionBone graft alternativesInflammatory responseRat modelBACKGROUND DATASpine fusionStudy groupNude ratsOsteogenic protein-1Athymic ratsFusion massOsteoinductive productsGraft alternativesDevelopment of a New Zealand White Rabbit Model of Spinal Pseudarthrosis Repair and Evaluation of the Potential Role of OP-1 to Overcome Pseudarthrosis
Grauer JN, Vaccaro AR, Kato M, Kwon BK, Beiner JM, Patel TC, Hilibrand AS, Chiba K, Albert TJ. Development of a New Zealand White Rabbit Model of Spinal Pseudarthrosis Repair and Evaluation of the Potential Role of OP-1 to Overcome Pseudarthrosis. Spine 2004, 29: 1405-1412. PMID: 15223930, DOI: 10.1097/01.brs.0000129028.25671.96.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 7Bone Morphogenetic ProteinsCotinineDrug Evaluation, PreclinicalFemaleHumansIliumInfusion Pumps, ImplantableLumbar VertebraeNicotinePostoperative ComplicationsPseudarthrosisRabbitsRadiographyRecombinant ProteinsSingle-Blind MethodSpinal DiseasesSpinal FusionTransforming Growth Factor betaTransplantation, AutologousWound HealingConceptsNew Zealand white rabbitsPosterolateral lumbar fusionOsteogenic protein-1Zealand white rabbitsLumbar fusionPseudarthrosis repairFusion massFusion rateWhite rabbitsManual palpationIliac crest autograftNew Zealand white rabbit modelTreatment of pseudarthrosesRabbit fusion modelWhite rabbit modelPresence of nicotineCrest autograftBACKGROUND DATAPseudarthrosesComputed tomographyAnimal modelsRabbit modelAutograftGraftWeeksPosterolateral lumbar fusions in athymic rats: characterization of a model
Grauer JN, Bomback DA, Lugo R, Troiano NW, Patel TC, Friedlaender GE. Posterolateral lumbar fusions in athymic rats: characterization of a model. The Spine Journal 2004, 4: 281-286. PMID: 15125850, DOI: 10.1016/j.spinee.2003.10.001.Peer-Reviewed Original ResearchConceptsPosterolateral lumbar fusion modelAthymic ratsManual palpationPosterolateral lumbar fusionL4-L5 levelSmall animal modelsPotential inflammatory responseLumbar fusionInflammatory responseSpinal fusionHistology resultsAutograft fusionAnimal modelsFusion rateOsteoinductive productsRatsIntertransverse fusionPalpationSurvival surgeryGraftWeeksComparison of FusionSpontaneous fusionLimited utilityXenogenic proteins
2003
Bone Graft Alternatives for Spinal Fusion
Grauer JN, Beiner JM, Kwon BK, Vaccaro AR. Bone Graft Alternatives for Spinal Fusion. BioDrugs 2003, 17: 391-394. PMID: 14614762, DOI: 10.2165/00063030-200317060-00002.Chapters
2001
Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion
Patel T, Erulkar J, Grauer J, Troiano N, Panjabi M, Friedlaender G. Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion. Spine 2001, 26: 1656-1661. PMID: 11474350, DOI: 10.1097/00007632-200108010-00004.Peer-Reviewed Original ResearchConceptsPosterolateral lumbar fusionOsteogenic protein-1Inhibitory effectProtein 1Lumbar fusionRabbit posterolateral lumbar fusion modelRabbit posterolateral spine fusion modelFusion massRabbit modelSubcutaneous mini-osmotic pumpsPosterolateral lumbar fusion modelMini-osmotic pumpsNew Zealand white rabbitsNew Zealand white rabbit modelZealand white rabbitsPosterolateral spine fusionSpine fusion modelPosterolateral intertransverse process fusionWhite rabbit modelPresence of nicotineIntertransverse process fusionBone graft alternativesBony fusionBACKGROUND DATASpine fusionFlexibility Analysis of Posterolateral Fusions in a New Zealand White Rabbit Model
Erulkar J, Grauer J, Patel T, Panjabi M. Flexibility Analysis of Posterolateral Fusions in a New Zealand White Rabbit Model. Spine 2001, 26: 1125-1130. PMID: 11413423, DOI: 10.1097/00007632-200105150-00006.Peer-Reviewed Original ResearchConceptsPosterolateral fusionRabbit modelAutogenous iliac crest bone graftIliac crest bone graftTime pointsNew Zealand white rabbitsPosterolateral lumbar fusionAdult New Zealand white rabbitsCrest bone graftNew Zealand white rabbit modelZealand white rabbitsHuman cadaveric studyPosterolateral spinal fusionWhite rabbit modelVivo rabbit modelIntertransverse process fusionLumbar fusionClinical studiesBACKGROUND DATASpinal fusionAnimal studiesCadaveric studyBone graftWhite rabbitsManual palpationEvaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion
Grauer J, Patel T, Erulkar J, Troiano N, Panjabi M, Friedlaender G. Evaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion. Spine 2001, 26: 127-133. PMID: 11154530, DOI: 10.1097/00007632-200101150-00004.Peer-Reviewed Original ResearchConceptsIntertransverse process lumbar fusionIntertransverse process fusionManual palpationLumbar fusionOP-1Rabbit modelAutogenous iliac crest boneProcess fusionGraft substituteNew Zealand white rabbitsIliac crest boneOP-1 groupZealand white rabbitsMultidirectional flexibility testingAutograft specimensLess morbidityBiomechanical testing resultsCrest boneStudy groupAutograft groupBACKGROUND DATAFusion massWhite rabbitsL5-L6Bone graft substitute
2000
Biomechanical evaluation of the New Zealand white rabbit lumbar spine: a physiologic characterization
Grauer JN, Erulkar J, Patel T, Panjabi M. Biomechanical evaluation of the New Zealand white rabbit lumbar spine: a physiologic characterization. European Spine Journal 2000, 9: 250-255. PMID: 10905445, PMCID: PMC3611391, DOI: 10.1007/s005860000141.Peer-Reviewed Original Research