2014
MCP‐1 downregulates MMP‐9 export via vesicular redistribution to lysosomes in rat portal fibroblasts
Hickman DA, Syal G, Fausther M, Lavoie EG, Goree JR, Storrie B, Dranoff JA. MCP‐1 downregulates MMP‐9 export via vesicular redistribution to lysosomes in rat portal fibroblasts. Physiological Reports 2014, 2: e12153. PMID: 25413315, PMCID: PMC4255798, DOI: 10.14814/phy2.12153.Peer-Reviewed Original Research
2012
Role of purinergic P2X receptors in the control of liver homeostasis
Fausther M, Gonzales E, Dranoff JA. Role of purinergic P2X receptors in the control of liver homeostasis. Wiley Interdisciplinary Reviews Membrane Transport And Signalling 2012, 1: 341-348. PMID: 22662313, PMCID: PMC3364537, DOI: 10.1002/wmts.32.Peer-Reviewed Original ResearchBasic cellular functionsIntracellular signal transduction pathwaysNumerous membrane transportersSignal transduction pathwaysLiver homeostasisPurinergic signalingCellular functionsP2Y receptorsTissue homeostasisTransduction pathwaysP2X receptorsHepatic cellsMembrane transportersMammalian speciesCell cycleSignaling pathwaysSalvage pathwayProtein synthesisCell typesATP moleculesFunctional relevanceExtracellular mediumMembrane levelGlucose/lipid metabolismDifferent liver cell types
2007
Succinate is a paracrine signal for liver damage
Correa PR, Kruglov EA, Thompson M, Leite MF, Dranoff JA, Nathanson MH. Succinate is a paracrine signal for liver damage. Journal Of Hepatology 2007, 47: 262-269. PMID: 17451837, PMCID: PMC1986575, DOI: 10.1016/j.jhep.2007.03.016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFluorescent Antibody TechniqueIn Vitro TechniquesInfusions, IntravenousIschemiaLiverLiver DiseasesMaleParacrine CommunicationPerfusionPortal VeinPressureRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledReverse Transcriptase Polymerase Chain ReactionSignal TransductionSuccinic AcidTissue DistributionConceptsHepatic stellate cellsSuccinate receptorParacrine signalsStellate cell activationStellate cellsCell expression systemTime-lapse imagingRelease of succinateCell activationCytosolic Ca2Effect of succinatePrimary hepatic stellate cellsHepatic cell typesExpression systemQuiescent hepatic stellate cellsConfocal immunofluorescencePhysiological roleIschemic hepatocytesCell typesBiochemical assaysSingle cellsLiver damageBACKGROUND/Western blotCAMP production
1999
Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells.
Leite MF, Dranoff JA, Gao L, Nathanson MH. Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells. Biochemical Journal 1999, 337 ( Pt 2): 305-9. PMID: 9882629, PMCID: PMC1219966, DOI: 10.1042/0264-6021:3370305.Peer-Reviewed Original ResearchConceptsPancreatic acinar cellsNon-excitable cell typesCell typesCell types resultsAcinar cellsNon-excitable cellsRyanodine receptorSubcellular localizationPolarized epitheliumReverse transcription-PCRRat pancreatic acinar cellsTrisphosphate receptorCo-ordinated releaseType 2 RyRExcitable cellsRelease pathwayTranscription-PCRPrincipal Ca2Release channelApical regionCytosolic Ca2CellsFundamental roleRyRsPropagation of Ca2Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells
LEITE M, DRANOFF J, Ling G, NATHANSON M. Expression and subcellular localization of the ryanodine receptor in rat pancreatic acinar cells. Biochemical Journal 1999, 337: 305-309. DOI: 10.1042/bj3370305.Peer-Reviewed Original ResearchPancreatic acinar cellsNon-excitable cell typesCell typesCell types resultsAcinar cellsNon-excitable cellsRyanodine receptorSubcellular localizationPolarized epitheliumReverse transcription-PCRRat pancreatic acinar cellsTrisphosphate receptorCo-ordinated releaseType 2 RyRExcitable cellsRelease pathwayTranscription-PCRPrincipal Ca2Release channelApical regionCytosolic Ca2CellsFundamental roleRyRsPropagation of Ca2