2021
Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic Brain
Chang CF, Goods BA, Askenase MH, Beatty HE, Osherov A, DeLong JH, Hammond MD, Massey J, Landreneau M, Love JC, Sansing LH. Divergent Functions of Tissue-Resident and Blood-Derived Macrophages in the Hemorrhagic Brain. Stroke 2021, 52: 1798-1808. PMID: 33840225, PMCID: PMC8085165, DOI: 10.1161/strokeaha.120.032196.Peer-Reviewed Original ResearchConceptsMonocyte-derived macrophagesIntracerebral hemorrhageT cell proliferationCore transcriptional programDifferential gene expressionDistinct transcriptional signaturesBone marrow-derived macrophagesAntigen-specific T cell proliferationTranscriptional programsCD4 T cell proliferationLongitudinal transcriptomic analysisVivo phagocytosis assaysTranscriptomic analysisDivergent functionsMarrow-derived macrophagesMHCII genesTissue-resident microgliaAntigen-presenting capabilityAutologous blood injectionGene expressionPrimary microglia culturesInnate immune cellsPhagocytosis of debrisTranscriptional signatureBlood-derived macrophages
2020
Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses.
Coppock GM, Aronson LR, Park J, Qiu C, Park J, DeLong JH, Radaelli E, Suszták K, Hunter CA. Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses. The Journal Of Immunology 2020, 205: 377-386. PMID: 32522836, PMCID: PMC7368461, DOI: 10.4049/jimmunol.1901463.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseUnilateral ureteral obstructionIL-17AIL-27RαIL-27Ureteral obstructionKidney diseaseIL-27 actsImmune cell infiltratesCytokine IL-27Day of surgeryImmune-mediated pathologyTubular epithelial cellsDegree of injuryFibrosis AssociatedKidney injuryTh17 cellsTh17 responsesCell infiltrateSerum levelsInflammatory cascadeRenal fibrosisIL-17RAImmune cellsChemokine mRNA
2014
Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice
Chen L, Yang G, Monslow J, Todd L, Cormode DP, Tang J, Grant GR, DeLong JH, Tang SY, Lawson JA, Pure E, FitzGerald GA. Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 6828-6833. PMID: 24753592, PMCID: PMC4020105, DOI: 10.1073/pnas.1401797111.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseMicrosomal prostaglandin E synthaseProstaglandin E synthaseMPGES-1Vascular injuryOxidative stressVascular cellsReduced macrophage infiltrationInflammatory cardiovascular diseasesMacrophage foam cell formationVascular smooth muscle cellsReceptor-deficient animalsNitric oxide synthaseSmooth muscle cellsFoam cell formationAortic expressionLesional expressionHyperlipidemic miceMacrophage infiltrationProinflammatory cytokinesOxide synthasePlasma cholesterolCardiovascular diseaseCholesterol effluxTherapeutic rationale