PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection
Perry J, Shallberg L, Clark J, Gullicksrud J, DeLong J, Douglas B, Hart A, Lanzar Z, O’Dea K, Konradt C, Park J, Kuchroo J, Grubaugh D, Zaretsky A, Brodsky I, Malefyt R, Christian D, Sharpe A, Hunter C. PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection. Nature Immunology 2022, 23: 743-756. PMID: 35437326, PMCID: PMC9106844, DOI: 10.1038/s41590-022-01170-w.Peer-Reviewed Original ResearchConceptsPD-1ETreg cellsPD-L1Interleukin-10T cellsCell expressionInhibitory receptor PD-1Regulatory T cell populationDevelopment of immunopathologyTreg cell populationRegulatory T cellsEffector T cellsPD-1 interactionReceptor PD-1T cell populationsCell populationsMyeloid cell expressionT cell receptor activationLineage-specific deletionTreg cellsEffector phenotypeInfected miceCell receptor activationInflammatory processEarly interferon