2017
IL-27 LIMITS TYPE 2 IMMUNOPATHOLOGY FOLLOWING PARAINFLUENZA VIRUS INFECTION
Muallem G, Wagage S, Sun Y, DeLong JH, Valenzuela A, Christian DA, Pritchard G, Fang Q, Buza EL, Jain D, Elloso MM, López CB, Hunter CA. IL-27 LIMITS TYPE 2 IMMUNOPATHOLOGY FOLLOWING PARAINFLUENZA VIRUS INFECTION. PLOS Pathogens 2017, 13: e1006173. PMID: 28129374, PMCID: PMC5305264, DOI: 10.1371/journal.ppat.1006173.Peer-Reviewed Original ResearchConceptsParainfluenza virus infectionTh2 responsesIL-27Control miceT cellsVirus infectionParamyxovirus infectionDisease severityWeight lossPathogenic Th2 responsesQuality of CD4Type 2 immunopathologyT-cell depletionT cell responsesSevere lung lesionsPopulation of IFNParainfluenza infectionsPulmonary eosinophilsRespiratory paramyxovirusesT helperCell depletionLung lesionsImmune responseLimit pathologyCD4
2013
T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1
De Obaldia ME, Bell JJ, Wang X, Harly C, Yashiro-Ohtani Y, DeLong JH, Zlotoff DA, Sultana DA, Pear WS, Bhandoola A. T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1. Nature Immunology 2013, 14: 1277-1284. PMID: 24185616, PMCID: PMC4038953, DOI: 10.1038/ni.2760.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Transcription FactorsCCAAT-Enhancer-Binding Protein-alphaCell LineCell LineageCells, CulturedCytokinesDendritic CellsFemaleFlow CytometryGene ExpressionHomeodomain ProteinsLymphopoiesisMiceMice, Inbred C57BLMice, KnockoutMutationMyeloid CellsProtein BindingReceptor, Notch1Reverse Transcriptase Polymerase Chain ReactionSignal TransductionStem CellsT-LymphocytesTranscription Factor HES-1
2012
Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire
Kwok WW, Tan V, Gillette L, Littell CT, Soltis MA, LaFond RB, Yang J, James EA, DeLong JH. Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire. The Journal Of Immunology 2012, 188: 2537-2544. PMID: 22327072, PMCID: PMC3997369, DOI: 10.4049/jimmunol.1102190.Peer-Reviewed Original ResearchConceptsT cellsMemory repertoireAg-specific T cellsNaive repertoireNaive precursor frequencyT cell responsesFrequency of precursorsProtective AgImmunized subjectsTCR usageNaive CD4Precursor frequencyEpitope specificityCell responsesMurine repertoireDifferent epitopesNonvaccineesVaccineesImmunodominanceEpitopesCellsHuman repertoireSubjectsCD4HLA
2010
Direct ex vivo analysis of allergen-specific CD4+ T cells
Kwok WW, Roti M, DeLong JH, Tan V, Wambre E, James EA, Robinson D. Direct ex vivo analysis of allergen-specific CD4+ T cells. Journal Of Allergy And Clinical Immunology 2010, 125: 1407-1409.e1. PMID: 20513526, PMCID: PMC3909500, DOI: 10.1016/j.jaci.2010.03.037.Peer-Reviewed Original Research