2021
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
Goods BA, Askenase MH, Markarian E, Beatty HE, Drake RS, Fleming I, DeLong JH, Philip NH, Matouk CC, Awad IA, Zuccarello M, Hanley DF, Love JC, Shalek AK, Sansing LH, Investigators T. Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu. JCI Insight 2021, 6: e145857. PMID: 33749664, PMCID: PMC8026179, DOI: 10.1172/jci.insight.145857.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageAcute brain injurySystemic immune responsesBrain tissue injuryHigh mortality rateLocal cellular responseAcute injuryTreatment optionsIntracerebral eventsBrain injuryCerebral hematomaLeukocyte responseTissue injuryT cellsImmune responseCT scanMortality rateDevastating formImmune dynamicsTherapeutic interventionsLeukocyte dynamicsBrain tissuePatientsInvasive surgeryInjury
2019
Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis
Park J, DeLong JH, Knox JJ, Konradt C, Wojno EDT, Hunter CA. Impact of Interleukin-27p28 on T and B Cell Responses during Toxoplasmosis. Infection And Immunity 2019, 87: 10.1128/iai.00455-19. PMID: 31548322, PMCID: PMC6867838, DOI: 10.1128/iai.00455-19.Peer-Reviewed Original ResearchConceptsIL-27p28IL-27Parasite-specific antibody titersEffector T cell populationsT cell-mediated pathologyCell-mediated pathologyT cell activityReduced parasite burdenT cell populationsB cell responsesCentral nervous systemInterleukin-27Antibody titersMajor inhibitory effectHeterodimeric cytokineParasite replicationImmune serumNervous systemParasite burdenCell responsesCell activityInhibitory effectIntracellular parasitesCell populationsToxoplasmosisIL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors
DeLong JH, O'Hara Hall A, Rausch M, Moodley D, Perry J, Park J, Phan AT, Beiting DP, Kedl RM, Hill JA, Hunter CA. IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors. ImmunoHorizons 2019, 3: 13-25. PMID: 31356173, PMCID: PMC6994206, DOI: 10.4049/immunohorizons.1800083.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB7-H1 AntigenCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCostimulatory and Inhibitory T-Cell ReceptorsCTLA-4 AntigenFemaleInterleukinsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Antigen, T-CellReceptors, ImmunologicSpleenToxoplasmaToxoplasmosisTranscriptomeTransfectionConceptsT cell expressionMultiple inhibitory receptorsIL-27Inhibitory receptorsPD-L1LAG-3Cell expressionCTLA-4Effector cell expressionTCR stimulationEffector T cellsIL-27 productionT cell activationTim-3Cell surface moleculesCell-extrinsic factorsT cellsIR expressionCell activationTIGITInfectionTCR signalsSurface moleculesSynergistic inductionVivo overexpression
2018
Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1.
DeLong JH, Hall AO, Konradt C, Coppock GM, Park J, Harms Pritchard G, Hunter CA. Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1. The Journal Of Immunology 2018, 200: 1761-1770. PMID: 29358280, PMCID: PMC5821564, DOI: 10.4049/jimmunol.1701154.Peer-Reviewed Original ResearchConceptsT cell expressionIL-27T cellsEffector cellsSca-1Cell expressionPathogen-specific T cellsMemory precursor effector cellsEndogenous IL-27Identification of CD8Type I IFNMemory stem cellsCytokine-mediated signalsEffector CD4Ly6C expressionSca-1 expressionImmune populationsT-betExpression of Ly6CMemory populationMouse CD4I IFNLy6CIFNMouse splenocytes
2014
Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice
Chen L, Yang G, Monslow J, Todd L, Cormode DP, Tang J, Grant GR, DeLong JH, Tang SY, Lawson JA, Pure E, FitzGerald GA. Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 6828-6833. PMID: 24753592, PMCID: PMC4020105, DOI: 10.1073/pnas.1401797111.Peer-Reviewed Original ResearchConceptsInducible nitric oxide synthaseMicrosomal prostaglandin E synthaseProstaglandin E synthaseMPGES-1Vascular injuryOxidative stressVascular cellsReduced macrophage infiltrationInflammatory cardiovascular diseasesMacrophage foam cell formationVascular smooth muscle cellsReceptor-deficient animalsNitric oxide synthaseSmooth muscle cellsFoam cell formationAortic expressionLesional expressionHyperlipidemic miceMacrophage infiltrationProinflammatory cytokinesOxide synthasePlasma cholesterolCardiovascular diseaseCholesterol effluxTherapeutic rationale
2013
T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1
De Obaldia ME, Bell JJ, Wang X, Harly C, Yashiro-Ohtani Y, DeLong JH, Zlotoff DA, Sultana DA, Pear WS, Bhandoola A. T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1. Nature Immunology 2013, 14: 1277-1284. PMID: 24185616, PMCID: PMC4038953, DOI: 10.1038/ni.2760.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Transcription FactorsCCAAT-Enhancer-Binding Protein-alphaCell LineCell LineageCells, CulturedCytokinesDendritic CellsFemaleFlow CytometryGene ExpressionHomeodomain ProteinsLymphopoiesisMiceMice, Inbred C57BLMice, KnockoutMutationMyeloid CellsProtein BindingReceptor, Notch1Reverse Transcriptase Polymerase Chain ReactionSignal TransductionStem CellsT-LymphocytesTranscription Factor HES-1
2011
Ara h 1–reactive T cells in individuals with peanut allergy
DeLong JH, Simpson KH, Wambre E, James EA, Robinson D, Kwok WW. Ara h 1–reactive T cells in individuals with peanut allergy. Journal Of Allergy And Clinical Immunology 2011, 127: 1211-1218.e3. PMID: 21459424, PMCID: PMC3130623, DOI: 10.1016/j.jaci.2011.02.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SequenceAntigens, PlantArachisCD4-Positive T-LymphocytesCytokinesEpitope MappingEpitopes, T-LymphocyteFemaleGlycoproteinsHumansImmunologic MemoryInterleukin-4MaleMembrane ProteinsMiddle AgedMolecular Sequence DataPeanut HypersensitivityPlant ProteinsReceptors, CCR4Young Adult