2017
A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders
Wambre E, Bajzik V, DeLong JH, O'Brien K, Nguyen QA, Speake C, Gersuk VH, DeBerg HA, Whalen E, Ni C, Farrington M, Jeong D, Robinson D, Linsley PS, Vickery BP, Kwok WW. A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders. Science Translational Medicine 2017, 9 PMID: 28768806, PMCID: PMC5987220, DOI: 10.1126/scitranslmed.aam9171.Peer-Reviewed Original ResearchConceptsT cellsType 2 helper T cellsDisease-causing T cellsHuman memory THelper T cellsInflammatory response pathwaysClinical responseAllergic disordersAtopic individualsImmunomodulatory strategiesAllergic diseasesMemory TCell subsetsUseful biomarkerTherapeutic targetCell signatureCell subpopulationsPathogenic responsesDisease-related phenotypesCell typesCellsDistinct pathwaysCD161CD4Immunotherapy
2014
Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells
Renand A, Newbrough S, Wambre E, DeLong JH, Robinson D, Kwok WW. Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells. Journal Of Allergy And Clinical Immunology 2014, 134: 1456-1459.e7. PMID: 25224098, PMCID: PMC4349443, DOI: 10.1016/j.jaci.2014.07.048.Peer-Reviewed Original ResearchGrass‐specific CD4+ T‐cells exhibit varying degrees of cross‐reactivity, implications for allergen‐specific immunotherapy
Archila LD, DeLong JH, Wambre E, James EA, Robinson DM, Kwok WW. Grass‐specific CD4+ T‐cells exhibit varying degrees of cross‐reactivity, implications for allergen‐specific immunotherapy. Clinical & Experimental Allergy 2014, 44: 986-998. PMID: 24708411, PMCID: PMC4069242, DOI: 10.1111/cea.12324.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAllergensAmino Acid SequenceAntigens, PlantBasophilsCD4-Positive T-LymphocytesCross ReactionsCytokinesDesensitization, ImmunologicEpitopes, T-LymphocyteHLA AntigensHumansImmunoglobulin ELymphocyte ActivationPeptidesPoaceaePollenT-Cell Antigen Receptor SpecificityT-Lymphocyte SubsetsConceptsT cell epitopesReactive T cellsCross-reactive T-cell epitopesT cell levelsT cellsAllergic subjectsIntracellular cytokine staining assaysCross-reactive profilesEx vivo stainingAllergen-specific immunotherapySpecific T cellsGrass pollen allergensPhl p 1Staining assaysPhl pTetramer stainingImmunotherapy strategiesAllergic responsesComparison of frequencyAntigenic epitopesComparable frequencyVivo stainingEpitopesImmunotherapyAllergens
2013
Specific immunotherapy modifies allergen-specific CD4+ T-cell responses in an epitope-dependent manner
Wambre E, DeLong JH, James EA, Torres-Chinn N, Pfützner W, Möbs C, Durham SR, Till SJ, Robinson D, Kwok WW. Specific immunotherapy modifies allergen-specific CD4+ T-cell responses in an epitope-dependent manner. Journal Of Allergy And Clinical Immunology 2013, 133: 872-879.e7. PMID: 24373351, PMCID: PMC3961577, DOI: 10.1016/j.jaci.2013.10.054.Peer-Reviewed Original ResearchConceptsT cell responsesGrass pollen allergyAllergen-specific immunotherapyPollen allergyAllergen-specific T-cell responsesAllergen-specific Th2 cellsAllergen-specific CD4Epitope-dependent mannerEpitope hierarchyTr1 responsesTr1 cellsNonatopic subjectsAllergic inflammationPeripheral toleranceAllergic subjectsVaccine strategiesTh2 cellsAntigen stimulationDistinct functional profilesT cellsEpitope levelAllergyEpitope changesImmunotherapyCell deletion
2011
Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy
Wambre E, DeLong JH, James EA, LaFond RE, Robinson D, Kwok WW. Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy. Journal Of Allergy And Clinical Immunology 2011, 129: 544-551.e7. PMID: 21975176, PMCID: PMC3268867, DOI: 10.1016/j.jaci.2011.08.034.Peer-Reviewed Original ResearchConceptsNonallergic subjectsT cellsPollen allergyPeptide-MHC class II tetramersAllergen-specific T cellsChemoattractant receptor-homologous moleculeAllergen-specific CD4Natural pollen exposureAllergen-specific immunotherapyClass II tetramersProtective immune responseT cell outcomesIL-10 inductionLymphocyte expressionSpecific immunotherapyIL-10Allergic subjectsAllergy vaccinationCytokine productionImmune responseDifferentiation stageSeasonal allergiesPollen exposureAllergyProtective response