2017
A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders
Wambre E, Bajzik V, DeLong JH, O'Brien K, Nguyen QA, Speake C, Gersuk VH, DeBerg HA, Whalen E, Ni C, Farrington M, Jeong D, Robinson D, Linsley PS, Vickery BP, Kwok WW. A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders. Science Translational Medicine 2017, 9 PMID: 28768806, PMCID: PMC5987220, DOI: 10.1126/scitranslmed.aam9171.Peer-Reviewed Original ResearchConceptsT cellsType 2 helper T cellsDisease-causing T cellsHuman memory THelper T cellsInflammatory response pathwaysClinical responseAllergic disordersAtopic individualsImmunomodulatory strategiesAllergic diseasesMemory TCell subsetsUseful biomarkerTherapeutic targetCell signatureCell subpopulationsPathogenic responsesDisease-related phenotypesCell typesCellsDistinct pathwaysCD161CD4Immunotherapy
2014
Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells
Renand A, Newbrough S, Wambre E, DeLong JH, Robinson D, Kwok WW. Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells. Journal Of Allergy And Clinical Immunology 2014, 134: 1456-1459.e7. PMID: 25224098, PMCID: PMC4349443, DOI: 10.1016/j.jaci.2014.07.048.Peer-Reviewed Original Research
2013
Specific immunotherapy modifies allergen-specific CD4+ T-cell responses in an epitope-dependent manner
Wambre E, DeLong JH, James EA, Torres-Chinn N, Pfützner W, Möbs C, Durham SR, Till SJ, Robinson D, Kwok WW. Specific immunotherapy modifies allergen-specific CD4+ T-cell responses in an epitope-dependent manner. Journal Of Allergy And Clinical Immunology 2013, 133: 872-879.e7. PMID: 24373351, PMCID: PMC3961577, DOI: 10.1016/j.jaci.2013.10.054.Peer-Reviewed Original ResearchConceptsT cell responsesGrass pollen allergyAllergen-specific immunotherapyPollen allergyAllergen-specific T-cell responsesAllergen-specific Th2 cellsAllergen-specific CD4Epitope-dependent mannerEpitope hierarchyTr1 responsesTr1 cellsNonatopic subjectsAllergic inflammationPeripheral toleranceAllergic subjectsVaccine strategiesTh2 cellsAntigen stimulationDistinct functional profilesT cellsEpitope levelAllergyEpitope changesImmunotherapyCell deletion