IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors
DeLong JH, O'Hara Hall A, Rausch M, Moodley D, Perry J, Park J, Phan AT, Beiting DP, Kedl RM, Hill JA, Hunter CA. IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors. ImmunoHorizons 2019, 3: 13-25. PMID: 31356173, PMCID: PMC6994206, DOI: 10.4049/immunohorizons.1800083.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB7-H1 AntigenCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCostimulatory and Inhibitory T-Cell ReceptorsCTLA-4 AntigenFemaleInterleukinsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Antigen, T-CellReceptors, ImmunologicSpleenToxoplasmaToxoplasmosisTranscriptomeTransfectionConceptsT cell expressionMultiple inhibitory receptorsIL-27Inhibitory receptorsPD-L1LAG-3Cell expressionCTLA-4Effector cell expressionTCR stimulationEffector T cellsIL-27 productionT cell activationTim-3Cell surface moleculesCell-extrinsic factorsT cellsIR expressionCell activationTIGITInfectionTCR signalsSurface moleculesSynergistic inductionVivo overexpression