Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy
Wambre E, DeLong JH, James EA, LaFond RE, Robinson D, Kwok WW. Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy. Journal Of Allergy And Clinical Immunology 2011, 129: 544-551.e7. PMID: 21975176, PMCID: PMC3268867, DOI: 10.1016/j.jaci.2011.08.034.Peer-Reviewed Original ResearchConceptsNonallergic subjectsT cellsPollen allergyPeptide-MHC class II tetramersAllergen-specific T cellsChemoattractant receptor-homologous moleculeAllergen-specific CD4Natural pollen exposureAllergen-specific immunotherapyClass II tetramersProtective immune responseT cell outcomesIL-10 inductionLymphocyte expressionSpecific immunotherapyIL-10Allergic subjectsAllergy vaccinationCytokine productionImmune responseDifferentiation stageSeasonal allergiesPollen exposureAllergyProtective responseAra h 1–reactive T cells in individuals with peanut allergy
DeLong JH, Simpson KH, Wambre E, James EA, Robinson D, Kwok WW. Ara h 1–reactive T cells in individuals with peanut allergy. Journal Of Allergy And Clinical Immunology 2011, 127: 1211-1218.e3. PMID: 21459424, PMCID: PMC3130623, DOI: 10.1016/j.jaci.2011.02.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SequenceAntigens, PlantArachisCD4-Positive T-LymphocytesCytokinesEpitope MappingEpitopes, T-LymphocyteFemaleGlycoproteinsHumansImmunologic MemoryInterleukin-4MaleMembrane ProteinsMiddle AgedMolecular Sequence DataPeanut HypersensitivityPlant ProteinsReceptors, CCR4Young Adult