2007
Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus
Andrioli A, Alonso-Nanclares L, Arellano J, DeFelipe J. Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus. Neuroscience 2007, 149: 131-143. PMID: 17850980, DOI: 10.1016/j.neuroscience.2007.07.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCell CountEpilepsyFemaleHippocampusHumansMaleMiddle AgedParvalbuminsStereotaxic TechniquesConceptsNeuronal lossProtein parvalbuminIntractable temporal lobe epilepsyCalcium binding protein parvalbuminParvalbumin-immunoreactive cellsTotal neuronal lossHippocampal neuronal lossParvalbumin-immunoreactive neuronsPV-ir neuronsHuman epileptic hippocampusMesial temporal structuresTemporal lobe epilepsyBinding protein parvalbuminTotal neuronal densityQuantitative stereological methodsAutopsy hippocampiAxonal reorganizationPV-irHippocampal sclerosisEpileptic hippocampusLobe epilepsyNeuronal densityInhibitory circuitsEpileptogenic processGABAergic interneurons
2003
Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus
Arellano J, Muñoz A, Ballesteros-Yáñez I, Sola R, DeFelipe J. Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus. Brain 2003, 127: 45-64. PMID: 14534159, DOI: 10.1093/brain/awh004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCalbindinsCarrier ProteinsDentate GyrusEpilepsy, Temporal LobeFemaleGABA Plasma Membrane Transport ProteinsHippocampusHumansImmunoenzyme TechniquesInterneuronsMaleMembrane ProteinsMembrane Transport ProteinsMiddle AgedNeural Cell Adhesion Molecule L1Organic Anion TransportersParvalbuminsPresynaptic TerminalsS100 Calcium Binding Protein GSialic AcidsTerminology as TopicConceptsCalbindin D-28kChandelier cellsDentate gyrusProtein parvalbuminHippocampal formationSclerotic hippocampusGABAergic circuitsNeuron lossPyramidal layerCalcium-binding protein parvalbuminBasket formationImpairment of GABANormal hippocampal formationHuman epileptic hippocampusTemporal lobe epilepsyCortical pyramidal cellsAxon initial segmentNeural cell adhesion moleculeGABA transporter 1PV-immunoreactiveHippocampal sclerosisClinical characteristicsEpileptic hippocampusLobe epilepsyDifferent hippocampal fields
2001
Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex
DeFelipe J, Arellano J, Gómez A, Azmitia E, Muñoz A. Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex. The Journal Of Comparative Neurology 2001, 433: 148-155. PMID: 11283956, DOI: 10.1002/cne.1132.Peer-Reviewed Original ResearchConceptsChandelier cell axon terminalsGamma-aminobutyric acidPyramidal cell axonsCerebral cortexPyramidal cellsAxon terminalsCell axonsHuman cerebral cortexDouble-labeling experimentsPowerful inhibitory mechanismChandelier cellsMonkey neocortexGABAergic interneuronsImmunoreactive fibersSerotonin receptorsSerotonin afferentsAxonal specializationsParacrine mannerLayers IISynaptic connectionsImmunocytochemical methodsProximal portionInhibitory mechanismClose appositionConfocal laser microscopy
1999
Variation in the spatial relationship between parvalbumin immunoreactive interneurones and pyramidal neurones in rat somatosensory cortex
Elston G, DeFelipe J, Arellano J, del Carmen Gonzilez-Albo M, Rosa M. Variation in the spatial relationship between parvalbumin immunoreactive interneurones and pyramidal neurones in rat somatosensory cortex. Neuroreport 1999, 10: 2975-2979. PMID: 10549808, DOI: 10.1097/00001756-199909290-00019.Peer-Reviewed Original ResearchConceptsPyramidal neuronesLayer VLucifer YellowSomatosensory cortexLayer IIICell bodiesRat primary somatosensory cortexTangential cortical slicesPrimary somatosensory cortexImmunoreactive cell bodiesBasal dendritic fieldsRat somatosensory cortexCombination of antibodiesReceptive field propertiesDendritic territoriesCortical slicesInhibitory modulationDendritic fieldsCortical neuronesIntracellular injectionNeuronesCortexConfocal microscopyFunctional implicationsSlices