2023
Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation
Athonvarangkul D, Wysolmerski J. Crosstalk within a brain-breast-bone axis regulates mineral and skeletal metabolism during lactation. Frontiers In Physiology 2023, 14: 1121579. PMID: 36875035, PMCID: PMC9979219, DOI: 10.3389/fphys.2023.1121579.Peer-Reviewed Original ResearchBone lossExcess bone lossExcessive bone lossPostmenopausal osteoporosisBone turnoverRare entityMineral metabolismSkeletal metabolismNew therapiesBone qualityCalcium demandOsteoporosisMammary glandCalcium deliveryBone axisReversible physiological responseLactationHormonal signalsCurrent knowledgeMetabolismPhysiological responsesPregnancyHypothalamusPathophysiologyTherapy
2007
Conversations between breast and bone: Physiological bone loss during lactation as evolutionary template for osteolysis in breast cancer and pathological bone loss after menopause
Wysolmerski J. Conversations between breast and bone: Physiological bone loss during lactation as evolutionary template for osteolysis in breast cancer and pathological bone loss after menopause. BoneKEy Reports 2007, 4: 209-225. DOI: 10.1138/20070268.Peer-Reviewed Original ResearchBone lossBone resorptionBreast cancerParathyroid hormone-related proteinLow estrogen levelsPathological bone resorptionPost-menopausal womenPathological bone lossCalcium-sensing receptorPhysiological bone lossHormone-related proteinSkeletal calcium storesHypothalamic hypogonadismPTHrP levelsEstrogen levelsPTHrP productionSkeletal demineralizationMineral metabolismSkeletal responseBone diseaseNew therapiesCalcium storesBone recoveryBreastCalcium transport
2005
Hypercalcemia in Breast Cancer: An Echo of Bone Mobilization During Lactation?
DeMauro S, Wysolmerski J. Hypercalcemia in Breast Cancer: An Echo of Bone Mobilization During Lactation? Journal Of Mammary Gland Biology And Neoplasia 2005, 10: 157-167. PMID: 16025222, DOI: 10.1007/s10911-005-5398-9.BooksConceptsBreast cancer patientsBone resorptionCancer patientsBreast cancerParathyroid hormone-related proteinPathophysiology of hypercalcemiaMultiple skeletal metastasesPathological bone resorptionHormone-related proteinActivation of osteoclastsSecretion of cytokinesClass of drugsSkeletal calcium storesNormal breast cellsFrequent complicationSkeletal metastasesSignificant morbidityCalcium metabolismCurrent therapiesHypercalcemiaNew therapiesCalcium levelsOsteoclast differentiationCalcium storesPatients