2020
Calcium metabolism and breast cancer: Echoes of lactation?
Grinman D, Athonvarungkul D, Wysolmerski J, Jeong J. Calcium metabolism and breast cancer: Echoes of lactation? Current Opinion In Endocrine And Metabolic Research 2020, 15: 63-70. PMID: 33299957, PMCID: PMC7720883, DOI: 10.1016/j.coemr.2020.11.006.BooksBreast cancerSystemic calcium homeostasisBreast cancer cellsMaternal calciumMammary epithelial cellsCalcium metabolismBone metabolismSystemic metabolismIntracellular calciumMalignant behaviorCalcium homeostasisCalcium receptorCalcium secretionSeries of adaptationsUptake of calciumMammary glandEpithelial cellsCalcium transportCancer cellsCell proliferationExtracellular fluidCancerCalciumMetabolismLactation
2015
OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism
Ardeshirpour L, Dumitru C, Dann P, Sterpka J, VanHouten J, Kim W, Kostenuik P, Wysolmerski J. OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism. Endocrinology 2015, 156: 2762-2773. PMID: 25961842, PMCID: PMC4511126, DOI: 10.1210/en.2015-1232.Peer-Reviewed Original ResearchConceptsBone lossOPG treatmentOsteoblast numberActivated B cells ligandLactational bone lossMaternal calcium homeostasisMaternal calcium metabolismMilk calcium levelsRapid bone lossDietary calcium intakeMaternal bone lossBone resorption rateMaternal hypocalcemiaRecombinant OPGCalcium intakeMaternal deathsOsteoprotegerin levelsMaternal skeletonBone turnoverDietary calciumCalcium metabolismOsteoclast numberBone massOsteoclast activityAnabolic responseChapter 13 Physiological Actions of Parathyroid Hormone (PTH) and PTH-related Protein Epidermal, Mammary, Reproductive, and Pancreatic Tissues
Wysolmerski J. Chapter 13 Physiological Actions of Parathyroid Hormone (PTH) and PTH-related Protein Epidermal, Mammary, Reproductive, and Pancreatic Tissues. 2015, 203-221. DOI: 10.1016/b978-0-12-397166-1.00013-8.Peer-Reviewed Original ResearchFunction of PTHrPParathyroid hormoneType 1 PTH/PTHrP receptorPTH/PTHrP receptorSystemic calcium metabolismHormone-related proteinNon-skeletal sitesSpecific G-proteinCalcium metabolismIntracrine factorParathyroid glandsPTHrP receptorSystemic hormonesPancreatic tissueEndocrine pancreasPTHrPPhysiological actionsMammary glandHormoneG proteinsTissueChondrocyte differentiationReceptorsGlandSkeletal development
2013
Mammary-Specific Ablation of the Calcium-Sensing Receptor During Lactation Alters Maternal Calcium Metabolism, Milk Calcium Transport, and Neonatal Calcium Accrual
Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. Mammary-Specific Ablation of the Calcium-Sensing Receptor During Lactation Alters Maternal Calcium Metabolism, Milk Calcium Transport, and Neonatal Calcium Accrual. Endocrinology 2013, 154: 3031-3042. PMID: 23782944, PMCID: PMC3749485, DOI: 10.1210/en.2012-2195.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBiological TransportBone DevelopmentBone ResorptionCalciumCrosses, GeneticFemaleGene Expression RegulationLactationLactoglobulinsMammary Glands, AnimalMiceMice, KnockoutMice, TransgenicMilkParathyroid HormoneParathyroid Hormone-Related ProteinReceptors, Calcium-SensingRNA, MessengerConceptsRenal calcium excretionCalcium excretionCalcium metabolismBone resorptionCalcium transportMilk calciumMammary glandAccelerated bone resorptionMammary-specific ablationMaternal calcium metabolismDietary calcium intakeCalcium sensing receptorCalcium-sensing receptorSecretion of PTHrPSkeletal calcium storesMilk PTHrPCalcium intakePTH secretionPTHrP secretionMaternal boneBone turnoverBone metabolismOnset of lactationMaternal circulationSystemic calciumThe calcium-sensing receptor in the breast
VanHouten JN, Wysolmerski JJ. The calcium-sensing receptor in the breast. Best Practice & Research Clinical Endocrinology & Metabolism 2013, 27: 403-414. PMID: 23856268, PMCID: PMC3713417, DOI: 10.1016/j.beem.2013.02.011.BooksConceptsG-protein usageBreast cancer cellsCalcium-sensing receptorCalcium metabolismCancer cellsParathyroid hormone-related protein levelsBreast cellsMaternal calcium metabolismOsteolytic skeletal metastasesSystemic calcium metabolismEpithelial cellsNormal breast epithelial cellsFeed-forward cycleMalignant breast cellsNormal breast cellsBreast epithelial cellsSkeletal metastasesPTHrP productionPTHrP expressionMammary epithelial cellsCaSRCalcium transportProtein levelsTransport of calciumSupply of calciumChapter 66 Disorders of Calcium Metabolism
Dumitru C, Wysolmerski J. Chapter 66 Disorders of Calcium Metabolism. 2013, 2273-2309. DOI: 10.1016/b978-0-12-381462-3.00066-5.Peer-Reviewed Original ResearchCalcium metabolismCalcium levelsParathyroid hormone-related proteinMulti-organ dysfunctionHormone-related proteinMetabolic bone disordersExtracellular calcium levelsParathyroid hormone receptorPrinciples of managementParathyroid hormoneBone metabolismBone disordersPrevalent causeCalcium homeostasisOrgan systemsHormone receptorsDisease statesHypercalcemiaHypocalcemiaDisordersNormal regulationHormoneMetabolismReceptorsCritical role
2007
Weaning Triggers a Decrease in Receptor Activator of Nuclear Factor-κB Ligand Expression, Widespread Osteoclast Apoptosis, and Rapid Recovery of Bone Mass after Lactation in Mice
Ardeshirpour L, Dann P, Adams DJ, Nelson T, VanHouten J, Horowitz MC, Wysolmerski JJ. Weaning Triggers a Decrease in Receptor Activator of Nuclear Factor-κB Ligand Expression, Widespread Osteoclast Apoptosis, and Rapid Recovery of Bone Mass after Lactation in Mice. Endocrinology 2007, 148: 3875-3886. PMID: 17495007, DOI: 10.1210/en.2006-1467.Peer-Reviewed Original ResearchConceptsBone lossBone massBone turnoverReceptor activatorOsteoclast apoptosisRapid bone lossC-telopeptide levelsNumber of osteoclastsBone formation rateNuclear factor-kappaB ligand (RANKL) mRNANuclear factor-kappaB ligand (RANKL) expressionRapid recoveryLevels of osteocalcinCessation of lactationSkeletal anabolismPTH levelsCalcium metabolismBone resorptionBone histomorphometryBone microarchitectureCalcium levelsOsteoblast numberLigand expressionReciprocal decreaseBone recovery
2005
Hypercalcemia in Breast Cancer: An Echo of Bone Mobilization During Lactation?
DeMauro S, Wysolmerski J. Hypercalcemia in Breast Cancer: An Echo of Bone Mobilization During Lactation? Journal Of Mammary Gland Biology And Neoplasia 2005, 10: 157-167. PMID: 16025222, DOI: 10.1007/s10911-005-5398-9.BooksConceptsBreast cancer patientsBone resorptionCancer patientsBreast cancerParathyroid hormone-related proteinPathophysiology of hypercalcemiaMultiple skeletal metastasesPathological bone resorptionHormone-related proteinActivation of osteoclastsSecretion of cytokinesClass of drugsSkeletal calcium storesNormal breast cellsFrequent complicationSkeletal metastasesSignificant morbidityCalcium metabolismCurrent therapiesHypercalcemiaNew therapiesCalcium levelsOsteoclast differentiationCalcium storesPatients
2002
The Evolutionary Origins of Maternal Calcium and Bone Metabolism During Lactation
Wysolmerski JJ. The Evolutionary Origins of Maternal Calcium and Bone Metabolism During Lactation. Journal Of Mammary Gland Biology And Neoplasia 2002, 7: 267-276. PMID: 12751891, DOI: 10.1023/a:1022800716196.BooksConceptsLower vertebratesEvolutionary originEutherian mammalsBone metabolismBone resorptionMaternal adaptationDifferent speciesMammalsMaternal calcium homeostasisRenal calcium excretionVertebratesAbsorption of calciumCalcium homeostasisEgg productionMetabolismMaternal calciumCalcium excretionHuman pregnancyMaternal transferCalcium metabolismFetal growthMineral metabolismNursing mothersAdaptationPregnancy