A circuit mechanism for decision-making biases and NMDA receptor hypofunction
Cavanagh SE, Lam NH, Murray JD, Hunt LT, Kennerley SW. A circuit mechanism for decision-making biases and NMDA receptor hypofunction. ELife 2020, 9: e53664. PMID: 32988455, PMCID: PMC7524553, DOI: 10.7554/elife.53664.Peer-Reviewed Original ResearchConceptsNMDA-R hypofunctionCortical excitation/inhibition balanceExcitation/inhibition balanceNMDA receptor hypofunctionNMDA receptor antagonismNMDA-R antagonist ketamineCircuit-level mechanismsPotential neural mechanismsNeuropsychiatric symptomsReceptor hypofunctionReceptor antagonismInhibition balanceExcitatory neuronsInhibitory neuronsPharmacological modelPharmacological manipulationNeuropsychiatric disordersCircuit mechanismsHypofunctionVariable evidenceNeural mechanismsKetamineNeuronsBehavioral psychophysicsPossible effectsPsychRNN: An Accessible and Flexible Python Package for Training Recurrent Neural Network Models on Cognitive Tasks
Ehrlich DB, Stone JT, Brandfonbrener D, Atanasov A, Murray JD. PsychRNN: An Accessible and Flexible Python Package for Training Recurrent Neural Network Models on Cognitive Tasks. ENeuro 2020, 8: eneuro.0427-20.2020. PMID: 33328247, PMCID: PMC7814477, DOI: 10.1523/eneuro.0427-20.2020.Peer-Reviewed Original ResearchConceptsRecurrent neural networkCognitive tasksCognitive neurosciencePython packageTraining of animalsTraining recurrent neural networksNetwork modelArtificial recurrent neural networkDeep learning softwareDeep-learning methodsRecurrent neural network modelNeural network modelNeural representationCognitive computationsNeuroscience researchNeural networkRNN modelCurriculum learningNeuroscienceCircuit mechanismsAdditional customizationConnectivity patternsTaskSoftware packageComputational modeling frameworkTranscriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD
Burt JB, Preller KH, Demirtas M, Ji JL, Krystal JH, Vollenweider FX, Anticevic A, Murray JD. Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD. ELife 2021, 10: e69320. PMID: 34313217, PMCID: PMC8315798, DOI: 10.7554/elife.69320.Peer-Reviewed Original ResearchConceptsLysergic acid diethylamideEffects of LSDSerotonin 2A receptorPharmacological neuroimagingNeuromodulatory effectsPharmacological responseFunctional alterationsBrain physiologyCircuit mechanismsFunctional connectivityNeural functionBrain structuresPsychoactive drugsAcid diethylamideFunctional topographyPrecision medicineNeural differencesNeuroimagingAltered statesReceptorsEffects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model
Lam NH, Borduqui T, Hallak J, Roque A, Anticevic A, Krystal JH, Wang XJ, Murray JD. Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model. Journal Of Neuroscience 2021, 42: 1035-1053. PMID: 34887320, PMCID: PMC8824494, DOI: 10.1523/jneurosci.1371-20.2021.Peer-Reviewed Original ResearchConceptsCortical circuitsCognitive deficitsCortical circuit modelAltered excitation-inhibition balanceExcitatory pyramidal neuronsNMDA receptor hypofunctionCerebral cortical circuitsExcitation-inhibition balancePyramidal neuronsReceptor hypofunctionDistinct time coursesSynaptic excitationInhibitory interneuronsMultiple neuropsychiatric disordersBehavioral deficitsSynaptic balanceSynaptic levelLatest evidenceNeuropsychiatric disordersCognitive functionCircuit mechanismsBehavioral effectsPsychometric performanceBehavioral levelTask paradigmGeometry of neural computation unifies working memory and planning
Ehrlich DB, Murray JD. Geometry of neural computation unifies working memory and planning. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2115610119. PMID: 36067286, PMCID: PMC9478653, DOI: 10.1073/pnas.2115610119.Peer-Reviewed Original ResearchConceptsNeural dataPossible circuit mechanismReal-world tasksMemory taskUpcoming eventsSensory modelPrefrontal cortexCognitive functionRecurrent neural networkHuman behaviorNeurophysiological observationsMemoryCircuit mechanismsFalsifiable predictionsFuture behaviorTaskModular processRepresentational strategiesRepresentationNeural networkCortexBehaviorDistinct typesBrainFindings