2018
Does Urinary Bisphenol-A Change after Bariatric Surgery?
Dambkowski CL, Garcia L, Leva N, Morton JM. Does Urinary Bisphenol-A Change after Bariatric Surgery? Journal Of The American College Of Surgeons 2018, 227: 232-237. PMID: 29753982, DOI: 10.1016/j.jamcollsurg.2018.04.033.Peer-Reviewed Original ResearchMeSH KeywordsBariatric SurgeryBenzhydryl CompoundsBiomarkersCaliforniaFemaleHumansInsulin ResistanceMaleMiddle AgedPhenolsProspective StudiesWeight LossConceptsBariatric surgery patientsBPA excretionSurgery patientsInsulin resistanceHeavier patientsHighest volume chemicalsBPA levelsSurgical weight lossUrinary BPA excretionUrinary BPA levelsHigher urinary excretionSingle academic institutionT-testStudent's t-testAverage weightLighter patientsPostoperative urineUrinary bisphenolBariatric surgeryPostoperative dataHemoglobin A1cPatient weightUrinary excretionLaboratory valuesPatients
2017
Adipose tissue macrophages impair preadipocyte differentiation in humans
Liu LF, Craig CM, Tolentino LL, Choi O, Morton J, Rivas H, Cushman SW, Engleman EG, McLaughlin T. Adipose tissue macrophages impair preadipocyte differentiation in humans. PLOS ONE 2017, 12: e0170728. PMID: 28151993, PMCID: PMC5289462, DOI: 10.1371/journal.pone.0170728.Peer-Reviewed Original ResearchConceptsImpaired adipocyte differentiationSystemic insulin resistanceInsulin resistanceAdipocyte differentiationPreadipocyte differentiationMacrophage removalImpaired preadipocyte differentiationProinflammatory immune cellsAdipose tissue inflammationAbsence of CD14Insulin-resistant humansAdipose tissue samplesOil Red ODifferentiation of preadipocytesBariatric surgeryProinflammatory cytokinesInflammatory cytokinesTissue inflammationImmune cellsCytokine secretionAdiponectin secretionAdipogenic gene expressionPhysiologic mechanismsAdipose tissueVAT adipocytes
2014
T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans
McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E. T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34: 2637-2643. PMID: 25341798, PMCID: PMC4445971, DOI: 10.1161/atvbaha.114.304636.Peer-Reviewed Original ResearchConceptsCD8 T cellsSubcutaneous adipose tissueT cell profileInsulin resistanceT cellsAdipose tissueSystemic inflammationPeripheral bloodPlasma high-sensitivity C-reactive protein concentrationsHigh-sensitivity C-reactive protein concentrationsAnti-inflammatory T cellsAnti-inflammatory interleukin-10C-reactive protein concentrationsDiet-induced obese miceObesity-associated metabolic diseasesInsulin-mediated glucose disposalProinflammatory T helperPlasma interleukin-6T cell subsetsInsulin suppression testT-cell phenotypeSystemic insulin resistanceAdipose tissue biopsiesObese human subjectsReal-time polymerase chain reaction
2009
Differential Intra-abdominal Adipose Tissue Profiling in Obese, Insulin-resistant Women
Liu A, McLaughlin T, Liu T, Sherman A, Yee G, Abbasi F, Lamendola C, Morton J, Cushman SW, Reaven GM, Tsao PS. Differential Intra-abdominal Adipose Tissue Profiling in Obese, Insulin-resistant Women. Obesity Surgery 2009, 19: 1564. PMID: 19711137, PMCID: PMC3181138, DOI: 10.1007/s11695-009-9949-9.Peer-Reviewed Original ResearchConceptsVisceral adipose tissueSubcutaneous adipose tissueBody mass indexInflammatory activityAdipose tissueIR individualsAbdominal subcutaneous adipose tissueOmental visceral adipose tissueInsulin-resistant womenInsulin suppression testDegree of adiposityInsulin-sensitive individualsReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionAdipocyte differentiation genesRegional fat storageIR womenBeckman Coulter MultisizerSmall adipose cellsBariatric surgeryObese womenObese/Mass indexLarge cellsAdipocyte hypertrophyPlasma Glucose and Insulin Regulation Is Abnormal Following Gastric Bypass Surgery with or Without Neuroglycopenia
Kim SH, Liu TC, Abbasi F, Lamendola C, Morton JM, Reaven GM, McLaughlin TL. Plasma Glucose and Insulin Regulation Is Abnormal Following Gastric Bypass Surgery with or Without Neuroglycopenia. Obesity Surgery 2009, 19: 1550. PMID: 19557485, DOI: 10.1007/s11695-009-9893-8.Peer-Reviewed Original ResearchConceptsGastric bypass surgeryInsulin sensitivityOral glucoseInsulin concentrationsPost-RYGBBypass surgeryPlasma glucoseInsulin responseControl groupOverweight/obese controlsInsulin suppression testOral glucose challengePeak insulin concentrationsNon-surgical controlsNadir glucose concentrationsAsymptomatic patientsSymptomatic hypoglycemiaObese controlsRYGB groupGlucose challengeSuppression testPeak glucosePatientsRYGBGlucose concentration